| Full name: citrate synthase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 1431 | HGNC ID: HGNC:2422 | Ensembl Gene: ENSG00000062485 | OMIM ID: 118950 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CS | 1431 | 208660_at | -0.1235 | 0.7831 | |
| GSE20347 | CS | 1431 | 208660_at | -0.3082 | 0.0086 | |
| GSE23400 | CS | 1431 | 208660_at | -0.0931 | 0.0821 | |
| GSE26886 | CS | 1431 | 208660_at | -0.5879 | 0.0050 | |
| GSE29001 | CS | 1431 | 208660_at | -0.4903 | 0.0227 | |
| GSE38129 | CS | 1431 | 208660_at | -0.2036 | 0.0241 | |
| GSE45670 | CS | 1431 | 208660_at | -0.3026 | 0.0288 | |
| GSE53622 | CS | 1431 | 60625 | -0.4854 | 0.0000 | |
| GSE53624 | CS | 1431 | 60625 | -0.2554 | 0.0000 | |
| GSE63941 | CS | 1431 | 208660_at | 1.4096 | 0.0001 | |
| GSE77861 | CS | 1431 | 208660_at | -0.2379 | 0.2756 | |
| GSE97050 | CS | A_21_P0011678 | -0.2555 | 0.2237 | ||
| SRP007169 | CS | 1431 | RNAseq | -0.9805 | 0.0103 | |
| SRP008496 | CS | 1431 | RNAseq | -0.9867 | 0.0000 | |
| SRP064894 | CS | 1431 | RNAseq | -0.5049 | 0.0000 | |
| SRP133303 | CS | 1431 | RNAseq | -0.0550 | 0.7245 | |
| SRP159526 | CS | 1431 | RNAseq | -0.4351 | 0.0525 | |
| SRP193095 | CS | 1431 | RNAseq | -0.3964 | 0.0002 | |
| SRP219564 | CS | 1431 | RNAseq | -0.1279 | 0.5631 | |
| TCGA | CS | 1431 | RNAseq | -0.0593 | 0.1263 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CS | 1431 | 7 | 2 | 21 | |
| GSE20123 | CS | 1431 | 7 | 1 | 22 | |
| GSE43470 | CS | 1431 | 4 | 0 | 39 | |
| GSE46452 | CS | 1431 | 8 | 1 | 50 | |
| GSE47630 | CS | 1431 | 10 | 2 | 28 | |
| GSE54993 | CS | 1431 | 0 | 5 | 65 | |
| GSE54994 | CS | 1431 | 4 | 1 | 48 | |
| GSE60625 | CS | 1431 | 0 | 0 | 11 | |
| GSE74703 | CS | 1431 | 4 | 0 | 32 | |
| GSE74704 | CS | 1431 | 4 | 1 | 15 | |
| TCGA | CS | 1431 | 14 | 10 | 72 |
Total number of gains: 62; Total number of losses: 23; Total Number of normals: 403.
Somatic mutations of CS:
Generating mutation plots.
Highly correlated genes for CS:
Showing top 20/781 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CS | SH2B1 | 0.76063 | 3 | 0 | 3 |
| CS | PTGES3 | 0.738512 | 3 | 0 | 3 |
| CS | ATXN7L3B | 0.717109 | 3 | 0 | 3 |
| CS | FGFR2 | 0.714715 | 3 | 0 | 3 |
| CS | STK40 | 0.714462 | 6 | 0 | 5 |
| CS | MCCC1 | 0.71267 | 3 | 0 | 3 |
| CS | TP53RK | 0.712329 | 3 | 0 | 3 |
| CS | AP2M1 | 0.699991 | 3 | 0 | 3 |
| CS | KRAS | 0.697475 | 4 | 0 | 4 |
| CS | ZNF664 | 0.696219 | 3 | 0 | 3 |
| CS | ADM5 | 0.695848 | 3 | 0 | 3 |
| CS | CHCHD1 | 0.693094 | 5 | 0 | 5 |
| CS | ITSN2 | 0.685214 | 3 | 0 | 3 |
| CS | CASKIN2 | 0.684489 | 3 | 0 | 3 |
| CS | THYN1 | 0.678166 | 3 | 0 | 3 |
| CS | TCEANC2 | 0.674803 | 4 | 0 | 4 |
| CS | SLC29A1 | 0.672745 | 3 | 0 | 3 |
| CS | APIP | 0.66861 | 3 | 0 | 3 |
| CS | TEX261 | 0.662297 | 3 | 0 | 3 |
| CS | PRKCSH | 0.661659 | 3 | 0 | 3 |
For details and further investigation, click here
