FGFR2

 

Full name: fibroblast growth factor receptor 2 Alias Symbol: CEK3|TK14|TK25|ECT1|K-SAM|CD332
Type: protein-coding gene Cytoband: 10q26.13
Entrez ID: 2263 HGNC ID: HGNC:3689 Ensembl Gene: ENSG00000066468 OMIM ID: 176943
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 9/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

FGFR2 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05215Prostate cancer

 

Expression of FGFR2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FGFR2 2263 203638_s_at -0.8501 0.4143
GSE20347 FGFR2 2263 203638_s_at 0.3683 0.2796
GSE23400 FGFR2 2263 203638_s_at 0.1795 0.1671
GSE26886 FGFR2 2263 203638_s_at 0.3655 0.3710
GSE29001 FGFR2 2263 203638_s_at -0.1132 0.8417
GSE38129 FGFR2 2263 203638_s_at 0.3568 0.2262
GSE45670 FGFR2 2263 203638_s_at -0.4531 0.1748
GSE53622 FGFR2 2263 15597 0.0233 0.8814
GSE53624 FGFR2 2263 51428 0.0781 0.6016
GSE63941 FGFR2 2263 203638_s_at 4.8554 0.0012
GSE77861 FGFR2 2263 208228_s_at 0.6192 0.2888
GSE97050 FGFR2 2263 A_24_P206624 -0.5485 0.1557
SRP007169 FGFR2 2263 RNAseq 1.6544 0.0027
SRP008496 FGFR2 2263 RNAseq 2.2245 0.0000
SRP064894 FGFR2 2263 RNAseq -0.6214 0.0066
SRP133303 FGFR2 2263 RNAseq 0.0647 0.8348
SRP159526 FGFR2 2263 RNAseq 0.8817 0.0022
SRP193095 FGFR2 2263 RNAseq 0.0713 0.7465
SRP219564 FGFR2 2263 RNAseq -0.2580 0.7042
TCGA FGFR2 2263 RNAseq 0.0370 0.7543

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by FGFR2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FGFR2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FGFR2 2263 2 6 22
GSE20123 FGFR2 2263 2 6 22
GSE43470 FGFR2 2263 0 9 34
GSE46452 FGFR2 2263 0 11 48
GSE47630 FGFR2 2263 2 14 24
GSE54993 FGFR2 2263 8 1 61
GSE54994 FGFR2 2263 1 9 43
GSE60625 FGFR2 2263 0 0 11
GSE74703 FGFR2 2263 0 6 30
GSE74704 FGFR2 2263 1 2 17
TCGA FGFR2 2263 4 28 64

Total number of gains: 20; Total number of losses: 92; Total Number of normals: 376.  

 

Somatic mutations of FGFR2:

 

Generating mutation plots.

 

Highly correlated genes for FGFR2:

 

Showing top 20/341 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FGFR2FEM1B0.757157303
FGFR2IPO80.735642303
FGFR2USP540.730823303
FGFR2NCOR10.730145303
FGFR2CALM10.72549303
FGFR2PRKAG10.721962303
FGFR2PPP1CB0.715059303
FGFR2CS0.714715303
FGFR2PNKD0.71384303
FGFR2MRPS300.696272404
FGFR2COPE0.692809303
FGFR2UBL70.687033303
FGFR2MORC2-AS10.686887303
FGFR2PPP2R1A0.685101303
FGFR2AIFM10.684838303
FGFR2MRPL420.676542303
FGFR2RSBN10.67649403
FGFR2SRP680.674645303
FGFR2SOX50.672147404
FGFR2TERF20.668866303

For details and further investigation, click here