| Full name: FA complementation group C | Alias Symbol: FAC|FA3 | ||
| Type: protein-coding gene | Cytoband: 9q22.32 | ||
| Entrez ID: 2176 | HGNC ID: HGNC:3584 | Ensembl Gene: ENSG00000158169 | OMIM ID: 613899 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FANCC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of FANCC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FANCC | 2176 | 205189_s_at | 0.2492 | 0.3083 | |
| GSE20347 | FANCC | 2176 | 205189_s_at | 0.2043 | 0.0153 | |
| GSE23400 | FANCC | 2176 | 205189_s_at | -0.0121 | 0.7568 | |
| GSE26886 | FANCC | 2176 | 205189_s_at | 0.2165 | 0.1527 | |
| GSE29001 | FANCC | 2176 | 205189_s_at | 0.3182 | 0.0551 | |
| GSE38129 | FANCC | 2176 | 205189_s_at | 0.2117 | 0.0211 | |
| GSE45670 | FANCC | 2176 | 205189_s_at | 0.2312 | 0.0062 | |
| GSE53622 | FANCC | 2176 | 8067 | 0.5321 | 0.0000 | |
| GSE53624 | FANCC | 2176 | 8067 | 0.9150 | 0.0000 | |
| GSE63941 | FANCC | 2176 | 205189_s_at | -0.1095 | 0.8327 | |
| GSE77861 | FANCC | 2176 | 205189_s_at | 0.0550 | 0.7230 | |
| GSE97050 | FANCC | 2176 | A_23_P32021 | -0.1314 | 0.6500 | |
| SRP007169 | FANCC | 2176 | RNAseq | 1.7497 | 0.0001 | |
| SRP008496 | FANCC | 2176 | RNAseq | 1.6327 | 0.0000 | |
| SRP064894 | FANCC | 2176 | RNAseq | 0.9770 | 0.0000 | |
| SRP133303 | FANCC | 2176 | RNAseq | -0.6227 | 0.0012 | |
| SRP159526 | FANCC | 2176 | RNAseq | 0.6997 | 0.0654 | |
| SRP193095 | FANCC | 2176 | RNAseq | 0.1517 | 0.3518 | |
| SRP219564 | FANCC | 2176 | RNAseq | 0.3920 | 0.1350 | |
| TCGA | FANCC | 2176 | RNAseq | 0.2199 | 0.0032 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by FANCC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FANCC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FANCC | 2176 | 5 | 8 | 17 | |
| GSE20123 | FANCC | 2176 | 5 | 8 | 17 | |
| GSE43470 | FANCC | 2176 | 6 | 3 | 34 | |
| GSE46452 | FANCC | 2176 | 6 | 14 | 39 | |
| GSE47630 | FANCC | 2176 | 1 | 17 | 22 | |
| GSE54993 | FANCC | 2176 | 4 | 2 | 64 | |
| GSE54994 | FANCC | 2176 | 8 | 11 | 34 | |
| GSE60625 | FANCC | 2176 | 0 | 0 | 11 | |
| GSE74703 | FANCC | 2176 | 5 | 3 | 28 | |
| GSE74704 | FANCC | 2176 | 2 | 6 | 12 | |
| TCGA | FANCC | 2176 | 25 | 22 | 49 |
Total number of gains: 67; Total number of losses: 94; Total Number of normals: 327.
Somatic mutations of FANCC:
Generating mutation plots.
Highly correlated genes for FANCC:
Showing top 20/471 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FANCC | RNF121 | 0.762549 | 3 | 0 | 3 |
| FANCC | TRMT2B | 0.740363 | 3 | 0 | 3 |
| FANCC | ZC3H7B | 0.737634 | 3 | 0 | 3 |
| FANCC | CSF1 | 0.736782 | 3 | 0 | 3 |
| FANCC | ZMIZ2 | 0.716855 | 3 | 0 | 3 |
| FANCC | FCHO1 | 0.716655 | 3 | 0 | 3 |
| FANCC | TRIM47 | 0.703258 | 3 | 0 | 3 |
| FANCC | SAG | 0.703057 | 4 | 0 | 4 |
| FANCC | STRADA | 0.688202 | 4 | 0 | 3 |
| FANCC | TRMU | 0.669582 | 3 | 0 | 3 |
| FANCC | SZT2 | 0.663944 | 4 | 0 | 3 |
| FANCC | NELL1 | 0.661501 | 3 | 0 | 3 |
| FANCC | TMEM229B | 0.660219 | 3 | 0 | 3 |
| FANCC | DOCK5 | 0.659483 | 3 | 0 | 3 |
| FANCC | EGR2 | 0.6593 | 4 | 0 | 3 |
| FANCC | HEXA | 0.658019 | 4 | 0 | 3 |
| FANCC | TSSK6 | 0.657658 | 3 | 0 | 3 |
| FANCC | MTMR4 | 0.655792 | 5 | 0 | 4 |
| FANCC | ZNF280C | 0.652448 | 4 | 0 | 3 |
| FANCC | PPP1R35 | 0.651081 | 4 | 0 | 3 |
For details and further investigation, click here
