| Full name: interleukin 5 receptor subunit alpha | Alias Symbol: CDw125|CD125 | ||
| Type: protein-coding gene | Cytoband: 3p26.2 | ||
| Entrez ID: 3568 | HGNC ID: HGNC:6017 | Ensembl Gene: ENSG00000091181 | OMIM ID: 147851 |
| Drug and gene relationship at DGIdb | |||
IL5RA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IL5RA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL5RA | 3568 | 207902_at | -0.1479 | 0.4826 | |
| GSE20347 | IL5RA | 3568 | 210744_s_at | 0.1377 | 0.0286 | |
| GSE23400 | IL5RA | 3568 | 210744_s_at | -0.1145 | 0.0076 | |
| GSE26886 | IL5RA | 3568 | 210744_s_at | 0.0277 | 0.8112 | |
| GSE29001 | IL5RA | 3568 | 210744_s_at | -0.0065 | 0.9686 | |
| GSE38129 | IL5RA | 3568 | 210744_s_at | -0.0604 | 0.4996 | |
| GSE45670 | IL5RA | 3568 | 210744_s_at | 0.0256 | 0.8049 | |
| GSE53622 | IL5RA | 3568 | 52544 | -0.5539 | 0.0000 | |
| GSE53624 | IL5RA | 3568 | 52544 | -0.7981 | 0.0000 | |
| GSE63941 | IL5RA | 3568 | 210744_s_at | 0.0567 | 0.7354 | |
| GSE77861 | IL5RA | 3568 | 210744_s_at | 0.0047 | 0.9644 | |
| GSE97050 | IL5RA | 3568 | A_33_P3328254 | 0.0809 | 0.7144 | |
| SRP133303 | IL5RA | 3568 | RNAseq | -0.1836 | 0.4972 | |
| SRP193095 | IL5RA | 3568 | RNAseq | -0.0093 | 0.9663 | |
| TCGA | IL5RA | 3568 | RNAseq | -1.5771 | 0.0650 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IL5RA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL5RA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL5RA | 3568 | 1 | 18 | 11 | |
| GSE20123 | IL5RA | 3568 | 1 | 18 | 11 | |
| GSE43470 | IL5RA | 3568 | 0 | 21 | 22 | |
| GSE46452 | IL5RA | 3568 | 2 | 18 | 39 | |
| GSE47630 | IL5RA | 3568 | 2 | 23 | 15 | |
| GSE54993 | IL5RA | 3568 | 6 | 1 | 63 | |
| GSE54994 | IL5RA | 3568 | 1 | 32 | 20 | |
| GSE60625 | IL5RA | 3568 | 5 | 0 | 6 | |
| GSE74703 | IL5RA | 3568 | 0 | 18 | 18 | |
| GSE74704 | IL5RA | 3568 | 1 | 11 | 8 | |
| TCGA | IL5RA | 3568 | 3 | 67 | 26 |
Total number of gains: 22; Total number of losses: 227; Total Number of normals: 239.
Somatic mutations of IL5RA:
Generating mutation plots.
Highly correlated genes for IL5RA:
Showing top 20/673 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL5RA | PPP5C | 0.75229 | 3 | 0 | 3 |
| IL5RA | STXBP6 | 0.7372 | 3 | 0 | 3 |
| IL5RA | CSN2 | 0.73227 | 3 | 0 | 3 |
| IL5RA | CSF1 | 0.728853 | 3 | 0 | 3 |
| IL5RA | APOB | 0.714624 | 4 | 0 | 4 |
| IL5RA | IKZF3 | 0.701932 | 3 | 0 | 3 |
| IL5RA | SLC6A5 | 0.697195 | 3 | 0 | 3 |
| IL5RA | IFNA10 | 0.696185 | 3 | 0 | 3 |
| IL5RA | FCAR | 0.690638 | 4 | 0 | 4 |
| IL5RA | H6PD | 0.6858 | 3 | 0 | 3 |
| IL5RA | ARHGAP44 | 0.685773 | 4 | 0 | 4 |
| IL5RA | ATG10 | 0.684421 | 6 | 0 | 6 |
| IL5RA | FGF23 | 0.676488 | 4 | 0 | 3 |
| IL5RA | ABCC9 | 0.671265 | 4 | 0 | 4 |
| IL5RA | TLL1 | 0.670639 | 3 | 0 | 3 |
| IL5RA | TCL1B | 0.668742 | 5 | 0 | 4 |
| IL5RA | PEX5L | 0.666896 | 3 | 0 | 3 |
| IL5RA | TECTA | 0.666497 | 3 | 0 | 3 |
| IL5RA | MYL3 | 0.666096 | 4 | 0 | 4 |
| IL5RA | CDON | 0.66059 | 5 | 0 | 5 |
For details and further investigation, click here
