| Full name: TAP binding protein | Alias Symbol: TAPA | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 6892 | HGNC ID: HGNC:11566 | Ensembl Gene: ENSG00000231925 | OMIM ID: 601962 |
| Drug and gene relationship at DGIdb | |||
TAPBP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation |
Expression of TAPBP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TAPBP | 6892 | 208829_at | 1.0138 | 0.0531 | |
| GSE20347 | TAPBP | 6892 | 208829_at | 0.4647 | 0.0108 | |
| GSE23400 | TAPBP | 6892 | 208829_at | 0.6056 | 0.0000 | |
| GSE26886 | TAPBP | 6892 | 208829_at | 0.4958 | 0.0868 | |
| GSE29001 | TAPBP | 6892 | 208829_at | 0.6425 | 0.0322 | |
| GSE38129 | TAPBP | 6892 | 208829_at | 0.5236 | 0.0016 | |
| GSE45670 | TAPBP | 6892 | 208829_at | 1.0002 | 0.0000 | |
| GSE53622 | TAPBP | 6892 | 64587 | 0.6970 | 0.0000 | |
| GSE53624 | TAPBP | 6892 | 11004 | 0.6493 | 0.0000 | |
| GSE63941 | TAPBP | 6892 | 208829_at | 0.3570 | 0.5489 | |
| GSE77861 | TAPBP | 6892 | 208829_at | 0.4375 | 0.2180 | |
| GSE97050 | TAPBP | 6892 | A_33_P3325914 | 0.8015 | 0.1290 | |
| SRP007169 | TAPBP | 6892 | RNAseq | 0.8125 | 0.1135 | |
| SRP008496 | TAPBP | 6892 | RNAseq | 0.7583 | 0.0107 | |
| SRP064894 | TAPBP | 6892 | RNAseq | 0.8959 | 0.0000 | |
| SRP133303 | TAPBP | 6892 | RNAseq | 0.5381 | 0.0001 | |
| SRP159526 | TAPBP | 6892 | RNAseq | 0.5455 | 0.0335 | |
| SRP193095 | TAPBP | 6892 | RNAseq | 0.5116 | 0.0006 | |
| SRP219564 | TAPBP | 6892 | RNAseq | 0.9979 | 0.0023 | |
| TCGA | TAPBP | 6892 | RNAseq | 0.1281 | 0.0048 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TAPBP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TAPBP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TAPBP | 6892 | 5 | 0 | 25 | |
| GSE20123 | TAPBP | 6892 | 5 | 0 | 25 | |
| GSE43470 | TAPBP | 6892 | 4 | 1 | 38 | |
| GSE46452 | TAPBP | 6892 | 2 | 9 | 48 | |
| GSE47630 | TAPBP | 6892 | 8 | 4 | 28 | |
| GSE54993 | TAPBP | 6892 | 3 | 1 | 66 | |
| GSE54994 | TAPBP | 6892 | 11 | 4 | 38 | |
| GSE60625 | TAPBP | 6892 | 1 | 0 | 10 | |
| GSE74703 | TAPBP | 6892 | 4 | 0 | 32 | |
| GSE74704 | TAPBP | 6892 | 2 | 0 | 18 | |
| TCGA | TAPBP | 6892 | 15 | 16 | 65 |
Total number of gains: 60; Total number of losses: 35; Total Number of normals: 393.
Somatic mutations of TAPBP:
Generating mutation plots.
Highly correlated genes for TAPBP:
Showing top 20/1561 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TAPBP | CD80 | 0.765994 | 3 | 0 | 3 |
| TAPBP | TMTC4 | 0.762268 | 3 | 0 | 3 |
| TAPBP | LEMD2 | 0.749982 | 4 | 0 | 4 |
| TAPBP | STAMBPL1 | 0.746638 | 3 | 0 | 3 |
| TAPBP | SLC39A3 | 0.738499 | 4 | 0 | 4 |
| TAPBP | UHMK1 | 0.736844 | 6 | 0 | 6 |
| TAPBP | PREX1 | 0.731124 | 4 | 0 | 4 |
| TAPBP | HMBOX1 | 0.729114 | 3 | 0 | 3 |
| TAPBP | ARMC6 | 0.726266 | 4 | 0 | 3 |
| TAPBP | SLC35B2 | 0.72458 | 3 | 0 | 3 |
| TAPBP | AGTRAP | 0.723879 | 5 | 0 | 5 |
| TAPBP | DTX3L | 0.716711 | 8 | 0 | 7 |
| TAPBP | FBXO6 | 0.715752 | 6 | 0 | 6 |
| TAPBP | LRRC8C | 0.712923 | 3 | 0 | 3 |
| TAPBP | SUCNR1 | 0.711335 | 4 | 0 | 4 |
| TAPBP | ZBTB9 | 0.710275 | 5 | 0 | 4 |
| TAPBP | TNFRSF1A | 0.709692 | 4 | 0 | 4 |
| TAPBP | RNF213 | 0.709672 | 5 | 0 | 4 |
| TAPBP | RAB34 | 0.705216 | 3 | 0 | 3 |
| TAPBP | C4orf46 | 0.704308 | 3 | 0 | 3 |
For details and further investigation, click here
