| Full name: COP9 signalosome subunit 7A | Alias Symbol: CSN7A | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 50813 | HGNC ID: HGNC:16758 | Ensembl Gene: ENSG00000111652 | OMIM ID: 616009 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COPS7A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COPS7A | 50813 | 209029_at | 0.1459 | 0.8505 | |
| GSE20347 | COPS7A | 50813 | 209029_at | 0.0058 | 0.9758 | |
| GSE23400 | COPS7A | 50813 | 209029_at | 0.1395 | 0.0146 | |
| GSE26886 | COPS7A | 50813 | 209029_at | -0.5052 | 0.2069 | |
| GSE29001 | COPS7A | 50813 | 209029_at | 0.0958 | 0.7817 | |
| GSE38129 | COPS7A | 50813 | 209029_at | -0.0445 | 0.7183 | |
| GSE45670 | COPS7A | 50813 | 209029_at | 0.1868 | 0.3012 | |
| GSE53622 | COPS7A | 50813 | 88205 | 0.0244 | 0.6737 | |
| GSE53624 | COPS7A | 50813 | 16040 | 0.1188 | 0.0054 | |
| GSE63941 | COPS7A | 50813 | 209029_at | 0.0881 | 0.8308 | |
| GSE77861 | COPS7A | 50813 | 209029_at | 0.1891 | 0.3365 | |
| GSE97050 | COPS7A | 50813 | A_23_P2474 | -0.1221 | 0.6076 | |
| SRP007169 | COPS7A | 50813 | RNAseq | -0.6109 | 0.0903 | |
| SRP008496 | COPS7A | 50813 | RNAseq | -0.7580 | 0.0002 | |
| SRP064894 | COPS7A | 50813 | RNAseq | 0.1814 | 0.2892 | |
| SRP133303 | COPS7A | 50813 | RNAseq | 0.3187 | 0.1979 | |
| SRP159526 | COPS7A | 50813 | RNAseq | 0.0408 | 0.8176 | |
| SRP193095 | COPS7A | 50813 | RNAseq | -0.0815 | 0.4332 | |
| SRP219564 | COPS7A | 50813 | RNAseq | 0.0587 | 0.8413 | |
| TCGA | COPS7A | 50813 | RNAseq | 0.0943 | 0.0498 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COPS7A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COPS7A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COPS7A | 50813 | 9 | 3 | 18 | |
| GSE20123 | COPS7A | 50813 | 9 | 3 | 18 | |
| GSE43470 | COPS7A | 50813 | 8 | 3 | 32 | |
| GSE46452 | COPS7A | 50813 | 10 | 1 | 48 | |
| GSE47630 | COPS7A | 50813 | 12 | 2 | 26 | |
| GSE54993 | COPS7A | 50813 | 1 | 10 | 59 | |
| GSE54994 | COPS7A | 50813 | 10 | 2 | 41 | |
| GSE60625 | COPS7A | 50813 | 0 | 1 | 10 | |
| GSE74703 | COPS7A | 50813 | 7 | 2 | 27 | |
| GSE74704 | COPS7A | 50813 | 5 | 2 | 13 | |
| TCGA | COPS7A | 50813 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 35; Total Number of normals: 342.
Somatic mutations of COPS7A:
Generating mutation plots.
Highly correlated genes for COPS7A:
Showing top 20/312 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COPS7A | HDAC6 | 0.770876 | 3 | 0 | 3 |
| COPS7A | ASH2L | 0.748822 | 3 | 0 | 3 |
| COPS7A | PTPRU | 0.74623 | 3 | 0 | 3 |
| COPS7A | MRPS15 | 0.744782 | 3 | 0 | 3 |
| COPS7A | DUSP16 | 0.743305 | 4 | 0 | 4 |
| COPS7A | ACRBP | 0.737508 | 3 | 0 | 3 |
| COPS7A | SP1 | 0.737231 | 3 | 0 | 3 |
| COPS7A | TMEM219 | 0.73678 | 3 | 0 | 3 |
| COPS7A | KDM4A | 0.73526 | 4 | 0 | 4 |
| COPS7A | FIS1 | 0.725331 | 4 | 0 | 4 |
| COPS7A | SRP68 | 0.724209 | 3 | 0 | 3 |
| COPS7A | ABHD14B | 0.720519 | 3 | 0 | 3 |
| COPS7A | CSF1 | 0.718501 | 3 | 0 | 3 |
| COPS7A | ZNF784 | 0.707085 | 3 | 0 | 3 |
| COPS7A | CTDSP1 | 0.70702 | 3 | 0 | 3 |
| COPS7A | PTOV1 | 0.706323 | 3 | 0 | 3 |
| COPS7A | NAB2 | 0.70567 | 3 | 0 | 3 |
| COPS7A | MRPS7 | 0.702946 | 5 | 0 | 5 |
| COPS7A | PRELID1 | 0.697401 | 3 | 0 | 3 |
| COPS7A | TNRC6B | 0.695957 | 3 | 0 | 3 |
For details and further investigation, click here
