| Full name: DISC1 scaffold protein | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q42.2 | ||
| Entrez ID: 27185 | HGNC ID: HGNC:2888 | Ensembl Gene: ENSG00000162946 | OMIM ID: 605210 |
| Drug and gene relationship at DGIdb | |||
Expression of DISC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DISC1 | 27185 | 1563744_a_at | -0.2864 | 0.2311 | |
| GSE20347 | DISC1 | 27185 | 217330_at | 0.0208 | 0.8142 | |
| GSE23400 | DISC1 | 27185 | 217330_at | -0.1394 | 0.0014 | |
| GSE26886 | DISC1 | 27185 | 1563744_a_at | 0.0453 | 0.7855 | |
| GSE29001 | DISC1 | 27185 | 217330_at | -0.0938 | 0.4650 | |
| GSE38129 | DISC1 | 27185 | 217330_at | -0.0867 | 0.2155 | |
| GSE45670 | DISC1 | 27185 | 1563744_a_at | 0.0376 | 0.7098 | |
| GSE53622 | DISC1 | 27185 | 79805 | 0.0189 | 0.8609 | |
| GSE53624 | DISC1 | 27185 | 26851 | -2.5160 | 0.0000 | |
| GSE63941 | DISC1 | 27185 | 1563744_a_at | -0.1121 | 0.4397 | |
| GSE77861 | DISC1 | 27185 | 1563744_a_at | -0.1507 | 0.1012 | |
| GSE97050 | DISC1 | 27185 | A_24_P83787 | 0.2636 | 0.2893 | |
| SRP007169 | DISC1 | 27185 | RNAseq | 2.2237 | 0.0083 | |
| SRP133303 | DISC1 | 27185 | RNAseq | 0.0247 | 0.9197 | |
| SRP159526 | DISC1 | 27185 | RNAseq | 0.2344 | 0.3571 | |
| SRP193095 | DISC1 | 27185 | RNAseq | 0.2142 | 0.1469 | |
| SRP219564 | DISC1 | 27185 | RNAseq | 0.5018 | 0.0889 | |
| TCGA | DISC1 | 27185 | RNAseq | 0.0892 | 0.5334 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by DISC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DISC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DISC1 | 27185 | 12 | 0 | 18 | |
| GSE20123 | DISC1 | 27185 | 12 | 0 | 18 | |
| GSE43470 | DISC1 | 27185 | 8 | 1 | 34 | |
| GSE46452 | DISC1 | 27185 | 4 | 2 | 53 | |
| GSE47630 | DISC1 | 27185 | 15 | 0 | 25 | |
| GSE54993 | DISC1 | 27185 | 0 | 6 | 64 | |
| GSE54994 | DISC1 | 27185 | 17 | 0 | 36 | |
| GSE60625 | DISC1 | 27185 | 0 | 0 | 11 | |
| GSE74703 | DISC1 | 27185 | 8 | 1 | 27 | |
| GSE74704 | DISC1 | 27185 | 6 | 0 | 14 | |
| TCGA | DISC1 | 27185 | 45 | 3 | 48 |
Total number of gains: 127; Total number of losses: 13; Total Number of normals: 348.
Somatic mutations of DISC1:
Generating mutation plots.
Highly correlated genes for DISC1:
Showing top 20/853 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DISC1 | FAM124A | 0.741919 | 3 | 0 | 3 |
| DISC1 | GBF1 | 0.735608 | 3 | 0 | 3 |
| DISC1 | HHLA1 | 0.730022 | 5 | 0 | 5 |
| DISC1 | STXBP6 | 0.729663 | 3 | 0 | 3 |
| DISC1 | ZMAT1 | 0.718282 | 3 | 0 | 3 |
| DISC1 | KCND3 | 0.711906 | 5 | 0 | 4 |
| DISC1 | NXPE4 | 0.709792 | 4 | 0 | 4 |
| DISC1 | EIF4E3 | 0.708873 | 4 | 0 | 4 |
| DISC1 | PLCE1 | 0.707786 | 3 | 0 | 3 |
| DISC1 | CSF1 | 0.704488 | 3 | 0 | 3 |
| DISC1 | ABHD1 | 0.702279 | 3 | 0 | 3 |
| DISC1 | RGS7BP | 0.70108 | 3 | 0 | 3 |
| DISC1 | BMP5 | 0.69809 | 3 | 0 | 3 |
| DISC1 | AFF3 | 0.697653 | 5 | 0 | 5 |
| DISC1 | PHYHD1 | 0.697356 | 4 | 0 | 4 |
| DISC1 | FAM149B1 | 0.696919 | 5 | 0 | 3 |
| DISC1 | SARDH | 0.695728 | 4 | 0 | 4 |
| DISC1 | NLGN4Y | 0.690058 | 4 | 0 | 3 |
| DISC1 | ANKRD31 | 0.688413 | 4 | 0 | 4 |
| DISC1 | PLXNB1 | 0.685372 | 4 | 0 | 4 |
For details and further investigation, click here
