| Full name: colony stimulating factor 3 receptor | Alias Symbol: GCSFR | ||
| Type: protein-coding gene | Cytoband: 1p34.3 | ||
| Entrez ID: 1441 | HGNC ID: HGNC:2439 | Ensembl Gene: ENSG00000119535 | OMIM ID: 138971 |
| Drug and gene relationship at DGIdb | |||
CSF3R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05200 | Pathways in cancer |
Expression of CSF3R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CSF3R | 1441 | 1553297_a_at | 0.7982 | 0.2066 | |
| GSE20347 | CSF3R | 1441 | 203591_s_at | 0.1642 | 0.2353 | |
| GSE23400 | CSF3R | 1441 | 203591_s_at | -0.0038 | 0.9443 | |
| GSE26886 | CSF3R | 1441 | 1553297_a_at | -0.0153 | 0.9416 | |
| GSE29001 | CSF3R | 1441 | 203591_s_at | -0.0511 | 0.7444 | |
| GSE38129 | CSF3R | 1441 | 203591_s_at | 0.0161 | 0.9047 | |
| GSE45670 | CSF3R | 1441 | 1553297_a_at | 0.2203 | 0.2812 | |
| GSE53622 | CSF3R | 1441 | 88796 | -0.2988 | 0.0000 | |
| GSE53624 | CSF3R | 1441 | 88796 | -0.2181 | 0.0146 | |
| GSE63941 | CSF3R | 1441 | 1553297_a_at | 0.1437 | 0.2658 | |
| GSE77861 | CSF3R | 1441 | 1553297_a_at | -0.0105 | 0.9519 | |
| GSE97050 | CSF3R | 1441 | A_33_P3881262 | -0.1985 | 0.4958 | |
| SRP007169 | CSF3R | 1441 | RNAseq | 2.6786 | 0.0112 | |
| SRP064894 | CSF3R | 1441 | RNAseq | 0.8784 | 0.0482 | |
| SRP133303 | CSF3R | 1441 | RNAseq | 1.5599 | 0.0001 | |
| SRP159526 | CSF3R | 1441 | RNAseq | 1.6209 | 0.0161 | |
| SRP193095 | CSF3R | 1441 | RNAseq | 2.6349 | 0.0000 | |
| SRP219564 | CSF3R | 1441 | RNAseq | 1.5444 | 0.0242 | |
| TCGA | CSF3R | 1441 | RNAseq | 0.0809 | 0.6536 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by CSF3R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CSF3R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CSF3R | 1441 | 3 | 5 | 22 | |
| GSE20123 | CSF3R | 1441 | 3 | 4 | 23 | |
| GSE43470 | CSF3R | 1441 | 7 | 2 | 34 | |
| GSE46452 | CSF3R | 1441 | 4 | 1 | 54 | |
| GSE47630 | CSF3R | 1441 | 8 | 3 | 29 | |
| GSE54993 | CSF3R | 1441 | 1 | 1 | 68 | |
| GSE54994 | CSF3R | 1441 | 11 | 2 | 40 | |
| GSE60625 | CSF3R | 1441 | 0 | 0 | 11 | |
| GSE74703 | CSF3R | 1441 | 6 | 1 | 29 | |
| GSE74704 | CSF3R | 1441 | 1 | 0 | 19 | |
| TCGA | CSF3R | 1441 | 11 | 18 | 67 |
Total number of gains: 55; Total number of losses: 37; Total Number of normals: 396.
Somatic mutations of CSF3R:
Generating mutation plots.
Highly correlated genes for CSF3R:
Showing top 20/287 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CSF3R | C20orf202 | 0.746274 | 3 | 0 | 3 |
| CSF3R | CDSN | 0.739512 | 3 | 0 | 3 |
| CSF3R | SLC25A35 | 0.73895 | 3 | 0 | 3 |
| CSF3R | SFTPA2 | 0.734966 | 3 | 0 | 3 |
| CSF3R | GRIN3B | 0.7297 | 3 | 0 | 3 |
| CSF3R | PROK2 | 0.719693 | 5 | 0 | 4 |
| CSF3R | GSX1 | 0.719098 | 4 | 0 | 4 |
| CSF3R | MRM1 | 0.717194 | 3 | 0 | 3 |
| CSF3R | CLDN18 | 0.7157 | 3 | 0 | 3 |
| CSF3R | CELA3A | 0.710882 | 4 | 0 | 4 |
| CSF3R | FCGR3B | 0.705923 | 6 | 0 | 5 |
| CSF3R | ITGB3 | 0.703152 | 3 | 0 | 3 |
| CSF3R | KCNIP2-AS1 | 0.688666 | 3 | 0 | 3 |
| CSF3R | NALCN-AS1 | 0.685371 | 3 | 0 | 3 |
| CSF3R | BMP3 | 0.684713 | 3 | 0 | 3 |
| CSF3R | GPR132 | 0.683772 | 3 | 0 | 3 |
| CSF3R | RGS3 | 0.682025 | 4 | 0 | 3 |
| CSF3R | THSD7A | 0.676871 | 3 | 0 | 3 |
| CSF3R | CDH24 | 0.674675 | 3 | 0 | 3 |
| CSF3R | PCBP3 | 0.674075 | 3 | 0 | 3 |
For details and further investigation, click here
