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Function: exec

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
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Multi-Omics Database of ESCC

 

FCGR3B

 

Full name: Fc fragment of IgG receptor IIIb Alias Symbol: CD16|CD16b
Type: protein-coding gene Cytoband: 1q23.3
Entrez ID: 2215 HGNC ID: HGNC:3620 Ensembl Gene: ENSG00000162747 OMIM ID: 610665
Drug and gene relationship at DGIdb

 

FCGR3B involved pathways:

KEGG pathway Description View
hsa04380Osteoclast differentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa05140Leishmaniasis
hsa05150Staphylococcus aureus infection
hsa05152Tuberculosis

 

Expression of FCGR3B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FCGR3B 2215 204007_at 1.1067 0.3235
GSE20347 FCGR3B 2215 204007_at 0.7471 0.0082
GSE23400 FCGR3B 2215 204007_at 0.6128 0.0000
GSE26886 FCGR3B 2215 204007_at 0.1251 0.7204
GSE29001 FCGR3B 2215 204007_at 1.3478 0.0007
GSE38129 FCGR3B 2215 204007_at 0.8257 0.0079
GSE45670 FCGR3B 2215 204007_at 1.0212 0.0613
GSE63941 FCGR3B 2215 204007_at 0.0023 0.9883
GSE77861 FCGR3B 2215 204007_at 0.3998 0.0286
SRP007169 FCGR3B 2215 RNAseq 3.6414 0.0014
SRP133303 FCGR3B 2215 RNAseq 2.4388 0.0000
SRP193095 FCGR3B 2215 RNAseq 2.6355 0.0000
TCGA FCGR3B 2215 RNAseq -0.5275 0.1886

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by FCGR3B expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of FCGR3B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FCGR3B 2215 10 0 20
GSE20123 FCGR3B 2215 10 0 20
GSE43470 FCGR3B 2215 7 2 34
GSE46452 FCGR3B 2215 2 1 56
GSE47630 FCGR3B 2215 14 0 26
GSE54993 FCGR3B 2215 0 5 65
GSE54994 FCGR3B 2215 16 0 37
GSE60625 FCGR3B 2215 0 0 11
GSE74703 FCGR3B 2215 7 2 27
GSE74704 FCGR3B 2215 4 0 16
TCGA FCGR3B 2215 43 4 49

Total number of gains: 113; Total number of losses: 14; Total Number of normals: 361.  

 

Somatic mutations of FCGR3B:

 

Generating mutation plots.

 

Highly correlated genes for FCGR3B:

 

Showing top 20/317 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FCGR3BPROK20.758097404
FCGR3BCEMIP0.717285303
FCGR3BFPR10.717023807
FCGR3BFCGR2A0.707075807
FCGR3BCSF3R0.705923605
FCGR3BSERPINA10.698953706
FCGR3BCD300A0.679868808
FCGR3BPF4V10.675151504
FCGR3BCOTL10.673895404
FCGR3BFCER1G0.67021807
FCGR3BCXCL50.667324605
FCGR3BC5AR10.663593806
FCGR3BPAG10.663321403
FCGR3BHAS20.655084503
FCGR3BMNDA0.654036807
FCGR3BCCNA10.652644303
FCGR3BTNFAIP60.645408707
FCGR3BDRAM10.644861606
FCGR3BTIMP10.644858707
FCGR3BCCR10.6428908

For details and further investigation, click here