| Full name: Fc fragment of IgG receptor IIIb | Alias Symbol: CD16|CD16b | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 2215 | HGNC ID: HGNC:3620 | Ensembl Gene: ENSG00000162747 | OMIM ID: 610665 |
| Related drugs: BROMOACETIC ACID, CHEMBL411250, CHOLECALCIFEROL, CHONDROITIN SULFATE, CYCLOSPORINE, CYTARABINE, DIMETHYL SULFOXIDE, DOXORUBICIN, EPOETIN ALFA, FENTANYL... [more] | |||
FCGR3B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation | |
| hsa04650 | Natural killer cell mediated cytotoxicity | |
| hsa05140 | Leishmaniasis | |
| hsa05150 | Staphylococcus aureus infection | |
| hsa05152 | Tuberculosis |
Expression of FCGR3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FCGR3B | 2215 | 204007_at | 1.1067 | 0.3235 | |
| GSE20347 | FCGR3B | 2215 | 204007_at | 0.7471 | 0.0082 | |
| GSE23400 | FCGR3B | 2215 | 204007_at | 0.6128 | 0.0000 | |
| GSE26886 | FCGR3B | 2215 | 204007_at | 0.1251 | 0.7204 | |
| GSE29001 | FCGR3B | 2215 | 204007_at | 1.3478 | 0.0007 | |
| GSE38129 | FCGR3B | 2215 | 204007_at | 0.8257 | 0.0079 | |
| GSE45670 | FCGR3B | 2215 | 204007_at | 1.0212 | 0.0613 | |
| GSE63941 | FCGR3B | 2215 | 204007_at | 0.0023 | 0.9883 | |
| GSE77861 | FCGR3B | 2215 | 204007_at | 0.3998 | 0.0286 | |
| SRP007169 | FCGR3B | 2215 | RNAseq | 3.6414 | 0.0014 | |
| SRP133303 | FCGR3B | 2215 | RNAseq | 2.4388 | 0.0000 | |
| SRP193095 | FCGR3B | 2215 | RNAseq | 2.6355 | 0.0000 | |
| TCGA | FCGR3B | 2215 | RNAseq | -0.5275 | 0.1886 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by FCGR3B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of FCGR3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FCGR3B | 2215 | 10 | 0 | 20 | |
| GSE20123 | FCGR3B | 2215 | 10 | 0 | 20 | |
| GSE43470 | FCGR3B | 2215 | 7 | 2 | 34 | |
| GSE46452 | FCGR3B | 2215 | 2 | 1 | 56 | |
| GSE47630 | FCGR3B | 2215 | 14 | 0 | 26 | |
| GSE54993 | FCGR3B | 2215 | 0 | 5 | 65 | |
| GSE54994 | FCGR3B | 2215 | 16 | 0 | 37 | |
| GSE60625 | FCGR3B | 2215 | 0 | 0 | 11 | |
| GSE74703 | FCGR3B | 2215 | 7 | 2 | 27 | |
| GSE74704 | FCGR3B | 2215 | 4 | 0 | 16 | |
| TCGA | FCGR3B | 2215 | 43 | 4 | 49 |
Total number of gains: 113; Total number of losses: 14; Total Number of normals: 361.
Somatic mutations of FCGR3B:
Generating mutation plots.
Highly correlated genes for FCGR3B:
Showing top 20/317 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FCGR3B | PROK2 | 0.758097 | 4 | 0 | 4 |
| FCGR3B | CEMIP | 0.717285 | 3 | 0 | 3 |
| FCGR3B | FPR1 | 0.717023 | 8 | 0 | 7 |
| FCGR3B | FCGR2A | 0.707075 | 8 | 0 | 7 |
| FCGR3B | CSF3R | 0.705923 | 6 | 0 | 5 |
| FCGR3B | SERPINA1 | 0.698953 | 7 | 0 | 6 |
| FCGR3B | CD300A | 0.679868 | 8 | 0 | 8 |
| FCGR3B | PF4V1 | 0.675151 | 5 | 0 | 4 |
| FCGR3B | COTL1 | 0.673895 | 4 | 0 | 4 |
| FCGR3B | FCER1G | 0.67021 | 8 | 0 | 7 |
| FCGR3B | CXCL5 | 0.667324 | 6 | 0 | 5 |
| FCGR3B | C5AR1 | 0.663593 | 8 | 0 | 6 |
| FCGR3B | PAG1 | 0.663321 | 4 | 0 | 3 |
| FCGR3B | HAS2 | 0.655084 | 5 | 0 | 3 |
| FCGR3B | MNDA | 0.654036 | 8 | 0 | 7 |
| FCGR3B | CCNA1 | 0.652644 | 3 | 0 | 3 |
| FCGR3B | TNFAIP6 | 0.645408 | 7 | 0 | 7 |
| FCGR3B | DRAM1 | 0.644861 | 6 | 0 | 6 |
| FCGR3B | TIMP1 | 0.644858 | 7 | 0 | 7 |
| FCGR3B | CCR1 | 0.6428 | 9 | 0 | 8 |
For details and further investigation, click here
