| Full name: glutamate ionotropic receptor NMDA type subunit 3B | Alias Symbol: GluN3B | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 116444 | HGNC ID: HGNC:16768 | Ensembl Gene: ENSG00000116032 | OMIM ID: 606651 |
| Drug and gene relationship at DGIdb | |||
GRIN3B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04724 | Glutamatergic synapse | |
| hsa05030 | Cocaine addiction | |
| hsa05031 | Amphetamine addiction | |
| hsa05034 | Alcoholism |
Expression of GRIN3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRIN3B | 116444 | 233892_at | -0.0084 | 0.9779 | |
| GSE26886 | GRIN3B | 116444 | 233892_at | 0.2405 | 0.0569 | |
| GSE45670 | GRIN3B | 116444 | 233892_at | 0.0181 | 0.8541 | |
| GSE63941 | GRIN3B | 116444 | 233892_at | 0.2440 | 0.1682 | |
| GSE77861 | GRIN3B | 116444 | 233892_at | 0.0571 | 0.5917 | |
| GSE97050 | GRIN3B | 116444 | A_33_P3394213 | 0.0526 | 0.8221 | |
| SRP133303 | GRIN3B | 116444 | RNAseq | 0.0277 | 0.9434 | |
| SRP159526 | GRIN3B | 116444 | RNAseq | 1.3252 | 0.0280 | |
| SRP219564 | GRIN3B | 116444 | RNAseq | -0.4594 | 0.3332 | |
| TCGA | GRIN3B | 116444 | RNAseq | 3.0779 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by GRIN3B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GRIN3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRIN3B | 116444 | 4 | 6 | 20 | |
| GSE20123 | GRIN3B | 116444 | 4 | 5 | 21 | |
| GSE43470 | GRIN3B | 116444 | 1 | 9 | 33 | |
| GSE46452 | GRIN3B | 116444 | 47 | 1 | 11 | |
| GSE47630 | GRIN3B | 116444 | 5 | 7 | 28 | |
| GSE54993 | GRIN3B | 116444 | 13 | 4 | 53 | |
| GSE54994 | GRIN3B | 116444 | 8 | 15 | 30 | |
| GSE60625 | GRIN3B | 116444 | 9 | 0 | 2 | |
| GSE74703 | GRIN3B | 116444 | 1 | 7 | 28 | |
| GSE74704 | GRIN3B | 116444 | 3 | 3 | 14 | |
| TCGA | GRIN3B | 116444 | 8 | 25 | 63 |
Total number of gains: 103; Total number of losses: 82; Total Number of normals: 303.
Somatic mutations of GRIN3B:
Generating mutation plots.
Highly correlated genes for GRIN3B:
Showing top 20/133 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRIN3B | TRIM47 | 0.805996 | 3 | 0 | 3 |
| GRIN3B | ZNF609 | 0.803607 | 3 | 0 | 3 |
| GRIN3B | NUDT18 | 0.782659 | 3 | 0 | 3 |
| GRIN3B | MATN4 | 0.757712 | 3 | 0 | 3 |
| GRIN3B | PHRF1 | 0.757436 | 3 | 0 | 3 |
| GRIN3B | BCORL1 | 0.753093 | 3 | 0 | 3 |
| GRIN3B | GTPBP10 | 0.752141 | 3 | 0 | 3 |
| GRIN3B | GPR132 | 0.751284 | 3 | 0 | 3 |
| GRIN3B | BCL9L | 0.738137 | 3 | 0 | 3 |
| GRIN3B | SLC2A4RG | 0.737623 | 3 | 0 | 3 |
| GRIN3B | CSF3R | 0.7297 | 3 | 0 | 3 |
| GRIN3B | CREB5 | 0.728454 | 3 | 0 | 3 |
| GRIN3B | LMF2 | 0.718494 | 3 | 0 | 3 |
| GRIN3B | CAPN12 | 0.715629 | 3 | 0 | 3 |
| GRIN3B | CCDC40 | 0.715265 | 3 | 0 | 3 |
| GRIN3B | SLC39A3 | 0.714999 | 3 | 0 | 3 |
| GRIN3B | INTS1 | 0.712397 | 3 | 0 | 3 |
| GRIN3B | MIER2 | 0.711563 | 3 | 0 | 3 |
| GRIN3B | IQCC | 0.709729 | 3 | 0 | 3 |
| GRIN3B | ITPKB-IT1 | 0.709211 | 3 | 0 | 3 |
For details and further investigation, click here
