| Full name: regulator of G protein signaling 3 | Alias Symbol: C2PA|FLJ20370|PDZ-RGS3 | ||
| Type: protein-coding gene | Cytoband: 9q32 | ||
| Entrez ID: 5998 | HGNC ID: HGNC:9999 | Ensembl Gene: ENSG00000138835 | OMIM ID: 602189 |
| Drug and gene relationship at DGIdb | |||
RGS3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of RGS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RGS3 | 5998 | 203823_at | 0.3718 | 0.5327 | |
| GSE20347 | RGS3 | 5998 | 203823_at | 0.3031 | 0.0002 | |
| GSE23400 | RGS3 | 5998 | 203823_at | 0.1874 | 0.0028 | |
| GSE26886 | RGS3 | 5998 | 203823_at | 1.1574 | 0.0005 | |
| GSE29001 | RGS3 | 5998 | 203823_at | 0.5745 | 0.0140 | |
| GSE38129 | RGS3 | 5998 | 203823_at | 0.2064 | 0.2910 | |
| GSE45670 | RGS3 | 5998 | 203823_at | 0.3527 | 0.1497 | |
| GSE53622 | RGS3 | 5998 | 31972 | 1.0372 | 0.0000 | |
| GSE53624 | RGS3 | 5998 | 31972 | 1.3324 | 0.0000 | |
| GSE63941 | RGS3 | 5998 | 203823_at | -1.3480 | 0.0451 | |
| GSE97050 | RGS3 | 5998 | A_24_P377775 | 0.0741 | 0.8956 | |
| SRP007169 | RGS3 | 5998 | RNAseq | 1.8146 | 0.0000 | |
| SRP008496 | RGS3 | 5998 | RNAseq | 2.0008 | 0.0000 | |
| SRP064894 | RGS3 | 5998 | RNAseq | 2.0503 | 0.0000 | |
| SRP133303 | RGS3 | 5998 | RNAseq | 0.5924 | 0.0379 | |
| SRP159526 | RGS3 | 5998 | RNAseq | 1.2179 | 0.0001 | |
| SRP193095 | RGS3 | 5998 | RNAseq | 1.0349 | 0.0000 | |
| SRP219564 | RGS3 | 5998 | RNAseq | 0.9167 | 0.1917 | |
| TCGA | RGS3 | 5998 | RNAseq | -0.2683 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 1.
Survival by RGS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RGS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RGS3 | 5998 | 4 | 10 | 16 | |
| GSE20123 | RGS3 | 5998 | 4 | 10 | 16 | |
| GSE43470 | RGS3 | 5998 | 4 | 3 | 36 | |
| GSE46452 | RGS3 | 5998 | 6 | 13 | 40 | |
| GSE47630 | RGS3 | 5998 | 3 | 16 | 21 | |
| GSE54993 | RGS3 | 5998 | 3 | 3 | 64 | |
| GSE54994 | RGS3 | 5998 | 9 | 10 | 34 | |
| GSE60625 | RGS3 | 5998 | 0 | 0 | 11 | |
| GSE74703 | RGS3 | 5998 | 4 | 3 | 29 | |
| GSE74704 | RGS3 | 5998 | 2 | 8 | 10 | |
| TCGA | RGS3 | 5998 | 26 | 22 | 48 |
Total number of gains: 65; Total number of losses: 98; Total Number of normals: 325.
Somatic mutations of RGS3:
Generating mutation plots.
Highly correlated genes for RGS3:
Showing top 20/1385 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RGS3 | RAB34 | 0.786156 | 3 | 0 | 3 |
| RGS3 | LRRC8C | 0.783333 | 3 | 0 | 3 |
| RGS3 | NT5M | 0.775312 | 3 | 0 | 3 |
| RGS3 | C20orf96 | 0.763036 | 3 | 0 | 3 |
| RGS3 | FADS1 | 0.75824 | 3 | 0 | 3 |
| RGS3 | DNAH11 | 0.753446 | 3 | 0 | 3 |
| RGS3 | RASSF4 | 0.752805 | 3 | 0 | 3 |
| RGS3 | CHN1 | 0.752519 | 11 | 0 | 11 |
| RGS3 | FCGR3A | 0.744386 | 4 | 0 | 4 |
| RGS3 | WDR54 | 0.738246 | 6 | 0 | 6 |
| RGS3 | LRRN4CL | 0.736545 | 3 | 0 | 3 |
| RGS3 | MMD | 0.733594 | 11 | 0 | 11 |
| RGS3 | SLC35B2 | 0.729768 | 3 | 0 | 3 |
| RGS3 | SPON2 | 0.729036 | 3 | 0 | 3 |
| RGS3 | GNG10 | 0.727451 | 3 | 0 | 3 |
| RGS3 | IKBIP | 0.726496 | 5 | 0 | 5 |
| RGS3 | CHST15 | 0.725914 | 10 | 0 | 10 |
| RGS3 | STARD3NL | 0.72341 | 6 | 0 | 6 |
| RGS3 | NME5 | 0.722808 | 3 | 0 | 3 |
| RGS3 | CNTLN | 0.722326 | 4 | 0 | 4 |
For details and further investigation, click here
