| Full name: cystatin E/M | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 1474 | HGNC ID: HGNC:2478 | Ensembl Gene: ENSG00000175315 | OMIM ID: 601891 |
| Drug and gene relationship at DGIdb | |||
Expression of CST6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CST6 | 1474 | 206595_at | -0.7641 | 0.7000 | |
| GSE20347 | CST6 | 1474 | 206595_at | -2.0928 | 0.0001 | |
| GSE23400 | CST6 | 1474 | 206595_at | -1.2269 | 0.0000 | |
| GSE26886 | CST6 | 1474 | 206595_at | -2.7661 | 0.0000 | |
| GSE29001 | CST6 | 1474 | 206595_at | -1.7311 | 0.0303 | |
| GSE38129 | CST6 | 1474 | 206595_at | -1.3931 | 0.0081 | |
| GSE45670 | CST6 | 1474 | 206595_at | -0.1346 | 0.8304 | |
| GSE53622 | CST6 | 1474 | 55773 | -0.8934 | 0.0000 | |
| GSE53624 | CST6 | 1474 | 55773 | -1.4472 | 0.0000 | |
| GSE63941 | CST6 | 1474 | 206595_at | 1.7035 | 0.3804 | |
| GSE77861 | CST6 | 1474 | 206595_at | -1.6323 | 0.0011 | |
| GSE97050 | CST6 | 1474 | A_23_P146946 | 0.8712 | 0.1195 | |
| SRP007169 | CST6 | 1474 | RNAseq | -4.9416 | 0.0000 | |
| SRP008496 | CST6 | 1474 | RNAseq | -2.2525 | 0.0340 | |
| SRP064894 | CST6 | 1474 | RNAseq | -1.2964 | 0.0287 | |
| SRP133303 | CST6 | 1474 | RNAseq | -1.4814 | 0.0000 | |
| SRP159526 | CST6 | 1474 | RNAseq | -3.0478 | 0.0000 | |
| SRP219564 | CST6 | 1474 | RNAseq | -3.2428 | 0.0021 | |
| TCGA | CST6 | 1474 | RNAseq | 1.3288 | 0.0027 |
Upregulated datasets: 1; Downregulated datasets: 13.
Survival by CST6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CST6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CST6 | 1474 | 8 | 4 | 18 | |
| GSE20123 | CST6 | 1474 | 8 | 4 | 18 | |
| GSE43470 | CST6 | 1474 | 6 | 1 | 36 | |
| GSE46452 | CST6 | 1474 | 11 | 3 | 45 | |
| GSE47630 | CST6 | 1474 | 7 | 5 | 28 | |
| GSE54993 | CST6 | 1474 | 3 | 0 | 67 | |
| GSE54994 | CST6 | 1474 | 8 | 5 | 40 | |
| GSE60625 | CST6 | 1474 | 0 | 3 | 8 | |
| GSE74703 | CST6 | 1474 | 4 | 0 | 32 | |
| GSE74704 | CST6 | 1474 | 6 | 2 | 12 | |
| TCGA | CST6 | 1474 | 24 | 6 | 66 |
Total number of gains: 85; Total number of losses: 33; Total Number of normals: 370.
Somatic mutations of CST6:
Generating mutation plots.
Highly correlated genes for CST6:
Showing top 20/1372 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CST6 | ZMYM2 | 0.770533 | 3 | 0 | 3 |
| CST6 | ATP6V1C2 | 0.765598 | 4 | 0 | 4 |
| CST6 | STXBP5 | 0.761902 | 6 | 0 | 6 |
| CST6 | CWH43 | 0.761643 | 10 | 0 | 10 |
| CST6 | RBM20 | 0.754643 | 3 | 0 | 3 |
| CST6 | ELOVL1 | 0.753805 | 3 | 0 | 3 |
| CST6 | CCDC85C | 0.751214 | 3 | 0 | 3 |
| CST6 | MXD1 | 0.733922 | 10 | 0 | 10 |
| CST6 | TOM1 | 0.733707 | 11 | 0 | 10 |
| CST6 | SLC25A51 | 0.731906 | 3 | 0 | 3 |
| CST6 | CRCT1 | 0.731189 | 11 | 0 | 10 |
| CST6 | CDA | 0.730257 | 13 | 0 | 12 |
| CST6 | ZNF416 | 0.72917 | 4 | 0 | 4 |
| CST6 | SBSN | 0.725643 | 7 | 0 | 6 |
| CST6 | C5orf66-AS1 | 0.720212 | 4 | 0 | 4 |
| CST6 | PDLIM2 | 0.71837 | 8 | 0 | 8 |
| CST6 | RDH12 | 0.718263 | 7 | 0 | 7 |
| CST6 | FLG | 0.717264 | 9 | 0 | 9 |
| CST6 | GPBP1 | 0.716685 | 3 | 0 | 3 |
| CST6 | GYS2 | 0.714587 | 9 | 0 | 9 |
For details and further investigation, click here
