| Full name: ATPase H+ transporting V1 subunit C2 | Alias Symbol: VMA5|ATP6C2 | ||
| Type: protein-coding gene | Cytoband: 2p25.1 | ||
| Entrez ID: 245973 | HGNC ID: HGNC:18264 | Ensembl Gene: ENSG00000143882 | OMIM ID: 618070 |
| Drug and gene relationship at DGIdb | |||
ATP6V1C2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway | |
| hsa05110 | Vibrio cholerae infection | |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
Expression of ATP6V1C2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATP6V1C2 | 245973 | 1553989_a_at | -1.2400 | 0.1410 | |
| GSE26886 | ATP6V1C2 | 245973 | 1553989_a_at | -3.4195 | 0.0000 | |
| GSE45670 | ATP6V1C2 | 245973 | 1553989_a_at | -1.2563 | 0.0069 | |
| GSE63941 | ATP6V1C2 | 245973 | 1553989_a_at | 1.2760 | 0.2313 | |
| GSE77861 | ATP6V1C2 | 245973 | 1553989_a_at | -1.0239 | 0.0089 | |
| GSE97050 | ATP6V1C2 | 245973 | A_24_P276932 | 1.0913 | 0.0700 | |
| SRP007169 | ATP6V1C2 | 245973 | RNAseq | -4.6174 | 0.0000 | |
| SRP008496 | ATP6V1C2 | 245973 | RNAseq | -4.2032 | 0.0000 | |
| SRP064894 | ATP6V1C2 | 245973 | RNAseq | -3.3592 | 0.0000 | |
| SRP133303 | ATP6V1C2 | 245973 | RNAseq | -2.8585 | 0.0000 | |
| SRP159526 | ATP6V1C2 | 245973 | RNAseq | -1.9546 | 0.0009 | |
| SRP193095 | ATP6V1C2 | 245973 | RNAseq | -2.3021 | 0.0000 | |
| SRP219564 | ATP6V1C2 | 245973 | RNAseq | -1.6141 | 0.0950 | |
| TCGA | ATP6V1C2 | 245973 | RNAseq | 0.2105 | 0.1555 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by ATP6V1C2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ATP6V1C2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATP6V1C2 | 245973 | 11 | 2 | 17 | |
| GSE20123 | ATP6V1C2 | 245973 | 11 | 2 | 17 | |
| GSE43470 | ATP6V1C2 | 245973 | 2 | 1 | 40 | |
| GSE46452 | ATP6V1C2 | 245973 | 3 | 4 | 52 | |
| GSE47630 | ATP6V1C2 | 245973 | 7 | 0 | 33 | |
| GSE54993 | ATP6V1C2 | 245973 | 0 | 7 | 63 | |
| GSE54994 | ATP6V1C2 | 245973 | 11 | 0 | 42 | |
| GSE60625 | ATP6V1C2 | 245973 | 0 | 3 | 8 | |
| GSE74703 | ATP6V1C2 | 245973 | 2 | 0 | 34 | |
| GSE74704 | ATP6V1C2 | 245973 | 9 | 1 | 10 | |
| TCGA | ATP6V1C2 | 245973 | 34 | 5 | 57 |
Total number of gains: 90; Total number of losses: 25; Total Number of normals: 373.
Somatic mutations of ATP6V1C2:
Generating mutation plots.
Highly correlated genes for ATP6V1C2:
Showing top 20/803 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATP6V1C2 | GYS2 | 0.861986 | 4 | 0 | 4 |
| ATP6V1C2 | SPNS2 | 0.86082 | 4 | 0 | 4 |
| ATP6V1C2 | GDPD3 | 0.847911 | 4 | 0 | 4 |
| ATP6V1C2 | SFTA2 | 0.847404 | 4 | 0 | 4 |
| ATP6V1C2 | FLG | 0.840495 | 4 | 0 | 4 |
| ATP6V1C2 | ESPL1 | 0.836562 | 4 | 0 | 4 |
| ATP6V1C2 | RANBP9 | 0.830053 | 4 | 0 | 4 |
| ATP6V1C2 | TTC9 | 0.8294 | 4 | 0 | 4 |
| ATP6V1C2 | EPS8L1 | 0.828282 | 4 | 0 | 4 |
| ATP6V1C2 | CRISP3 | 0.82336 | 4 | 0 | 4 |
| ATP6V1C2 | SCNN1B | 0.822702 | 4 | 0 | 4 |
| ATP6V1C2 | TRIP10 | 0.818483 | 4 | 0 | 4 |
| ATP6V1C2 | SLC46A2 | 0.813014 | 4 | 0 | 4 |
| ATP6V1C2 | PADI1 | 0.80888 | 4 | 0 | 4 |
| ATP6V1C2 | UPK1A | 0.806803 | 4 | 0 | 4 |
| ATP6V1C2 | SCIN | 0.805333 | 4 | 0 | 4 |
| ATP6V1C2 | ANXA9 | 0.804554 | 4 | 0 | 4 |
| ATP6V1C2 | CAB39L | 0.802834 | 4 | 0 | 4 |
| ATP6V1C2 | MXD1 | 0.800504 | 4 | 0 | 4 |
| ATP6V1C2 | NUCB2 | 0.799841 | 4 | 0 | 4 |
For details and further investigation, click here
