| Full name: filaggrin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 2312 | HGNC ID: HGNC:3748 | Ensembl Gene: ENSG00000143631 | OMIM ID: 135940 |
| Drug and gene relationship at DGIdb | |||
Expression of FLG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FLG | 2312 | 215704_at | -2.9815 | 0.1059 | |
| GSE20347 | FLG | 2312 | 215704_at | -4.2016 | 0.0000 | |
| GSE23400 | FLG | 2312 | 215704_at | -3.0149 | 0.0000 | |
| GSE26886 | FLG | 2312 | 215704_at | -5.6062 | 0.0000 | |
| GSE29001 | FLG | 2312 | 215704_at | -3.9080 | 0.0001 | |
| GSE38129 | FLG | 2312 | 215704_at | -3.6241 | 0.0000 | |
| GSE45670 | FLG | 2312 | 215704_at | -3.4958 | 0.0029 | |
| GSE53622 | FLG | 2312 | 38719 | -3.5179 | 0.0000 | |
| GSE53624 | FLG | 2312 | 38719 | -3.5072 | 0.0000 | |
| GSE63941 | FLG | 2312 | 215704_at | 0.7463 | 0.6415 | |
| GSE77861 | FLG | 2312 | 215704_at | -3.0230 | 0.0143 | |
| GSE97050 | FLG | 2312 | A_24_P51322 | -2.4163 | 0.1297 | |
| SRP007169 | FLG | 2312 | RNAseq | -6.4021 | 0.0001 | |
| SRP008496 | FLG | 2312 | RNAseq | -6.1472 | 0.0000 | |
| SRP064894 | FLG | 2312 | RNAseq | -7.1904 | 0.0000 | |
| SRP133303 | FLG | 2312 | RNAseq | -5.4449 | 0.0000 | |
| SRP159526 | FLG | 2312 | RNAseq | -5.2122 | 0.0000 | |
| SRP193095 | FLG | 2312 | RNAseq | -5.9930 | 0.0000 | |
| SRP219564 | FLG | 2312 | RNAseq | -6.0769 | 0.0000 | |
| TCGA | FLG | 2312 | RNAseq | 0.0158 | 0.9652 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by FLG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FLG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FLG | 2312 | 15 | 0 | 15 | |
| GSE20123 | FLG | 2312 | 15 | 0 | 15 | |
| GSE43470 | FLG | 2312 | 6 | 2 | 35 | |
| GSE46452 | FLG | 2312 | 2 | 1 | 56 | |
| GSE47630 | FLG | 2312 | 15 | 0 | 25 | |
| GSE54993 | FLG | 2312 | 0 | 4 | 66 | |
| GSE54994 | FLG | 2312 | 15 | 2 | 36 | |
| GSE60625 | FLG | 2312 | 0 | 0 | 11 | |
| GSE74703 | FLG | 2312 | 6 | 1 | 29 | |
| GSE74704 | FLG | 2312 | 7 | 0 | 13 | |
| TCGA | FLG | 2312 | 39 | 2 | 55 |
Total number of gains: 120; Total number of losses: 12; Total Number of normals: 356.
Somatic mutations of FLG:
Generating mutation plots.
Highly correlated genes for FLG:
Showing top 20/1656 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FLG | GYS2 | 0.891573 | 10 | 0 | 10 |
| FLG | ECM1 | 0.878582 | 11 | 0 | 11 |
| FLG | SFI1 | 0.875379 | 3 | 0 | 3 |
| FLG | EPS8L1 | 0.875117 | 11 | 0 | 11 |
| FLG | CRISP3 | 0.870455 | 11 | 0 | 11 |
| FLG | SFTA2 | 0.867145 | 4 | 0 | 4 |
| FLG | MXD1 | 0.865368 | 11 | 0 | 11 |
| FLG | ENDOU | 0.863455 | 11 | 0 | 11 |
| FLG | SCEL | 0.863423 | 11 | 0 | 11 |
| FLG | A2ML1 | 0.862308 | 7 | 0 | 7 |
| FLG | CYSRT1 | 0.858452 | 6 | 0 | 6 |
| FLG | SCNN1B | 0.858069 | 11 | 0 | 11 |
| FLG | NCCRP1 | 0.855637 | 3 | 0 | 3 |
| FLG | TMPRSS11B | 0.851625 | 7 | 0 | 7 |
| FLG | FAM3D | 0.85028 | 7 | 0 | 7 |
| FLG | CRCT1 | 0.849296 | 11 | 0 | 11 |
| FLG | PSCA | 0.847753 | 8 | 0 | 8 |
| FLG | FLG-AS1 | 0.844676 | 6 | 0 | 6 |
| FLG | UBL3 | 0.843459 | 11 | 0 | 11 |
| FLG | ATP6V1C2 | 0.840495 | 4 | 0 | 4 |
For details and further investigation, click here
