| Full name: phosphate cytidylyltransferase 1, choline, alpha | Alias Symbol: CT|CTPCT | ||
| Type: protein-coding gene | Cytoband: 3q29 | ||
| Entrez ID: 5130 | HGNC ID: HGNC:8754 | Ensembl Gene: ENSG00000161217 | OMIM ID: 123695 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PCYT1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05231 | Choline metabolism in cancer |
Expression of PCYT1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCYT1A | 5130 | 225069_at | 0.8664 | 0.0221 | |
| GSE20347 | PCYT1A | 5130 | 204209_at | 0.4080 | 0.0475 | |
| GSE23400 | PCYT1A | 5130 | 204209_at | 0.3431 | 0.0000 | |
| GSE26886 | PCYT1A | 5130 | 225069_at | 0.1220 | 0.6573 | |
| GSE29001 | PCYT1A | 5130 | 204209_at | 0.2051 | 0.3201 | |
| GSE38129 | PCYT1A | 5130 | 204209_at | 0.4948 | 0.0036 | |
| GSE45670 | PCYT1A | 5130 | 225069_at | 0.6600 | 0.0017 | |
| GSE53622 | PCYT1A | 5130 | 13501 | 0.5920 | 0.0000 | |
| GSE53624 | PCYT1A | 5130 | 35103 | 0.7133 | 0.0000 | |
| GSE63941 | PCYT1A | 5130 | 225069_at | -1.0607 | 0.0456 | |
| GSE77861 | PCYT1A | 5130 | 225069_at | 0.8448 | 0.0016 | |
| GSE97050 | PCYT1A | 5130 | A_23_P252681 | 0.4168 | 0.1785 | |
| SRP007169 | PCYT1A | 5130 | RNAseq | 1.0616 | 0.0015 | |
| SRP008496 | PCYT1A | 5130 | RNAseq | 1.1683 | 0.0000 | |
| SRP064894 | PCYT1A | 5130 | RNAseq | 0.6314 | 0.0008 | |
| SRP133303 | PCYT1A | 5130 | RNAseq | 1.0041 | 0.0000 | |
| SRP159526 | PCYT1A | 5130 | RNAseq | 0.9521 | 0.0246 | |
| SRP193095 | PCYT1A | 5130 | RNAseq | 0.8790 | 0.0000 | |
| SRP219564 | PCYT1A | 5130 | RNAseq | 0.2425 | 0.5909 | |
| TCGA | PCYT1A | 5130 | RNAseq | 0.1893 | 0.0126 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by PCYT1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCYT1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCYT1A | 5130 | 22 | 0 | 8 | |
| GSE20123 | PCYT1A | 5130 | 22 | 0 | 8 | |
| GSE43470 | PCYT1A | 5130 | 21 | 0 | 22 | |
| GSE46452 | PCYT1A | 5130 | 19 | 1 | 39 | |
| GSE47630 | PCYT1A | 5130 | 27 | 2 | 11 | |
| GSE54993 | PCYT1A | 5130 | 1 | 22 | 47 | |
| GSE54994 | PCYT1A | 5130 | 41 | 0 | 12 | |
| GSE60625 | PCYT1A | 5130 | 0 | 6 | 5 | |
| GSE74703 | PCYT1A | 5130 | 19 | 0 | 17 | |
| GSE74704 | PCYT1A | 5130 | 14 | 0 | 6 | |
| TCGA | PCYT1A | 5130 | 77 | 0 | 19 |
Total number of gains: 263; Total number of losses: 31; Total Number of normals: 194.
Somatic mutations of PCYT1A:
Generating mutation plots.
Highly correlated genes for PCYT1A:
Showing top 20/1150 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCYT1A | MAN2B1 | 0.875198 | 3 | 0 | 3 |
| PCYT1A | COMMD2 | 0.870355 | 3 | 0 | 3 |
| PCYT1A | FAM89B | 0.79544 | 3 | 0 | 3 |
| PCYT1A | ALKBH6 | 0.793448 | 4 | 0 | 4 |
| PCYT1A | ZNF518B | 0.78867 | 3 | 0 | 3 |
| PCYT1A | LRRC58 | 0.784243 | 4 | 0 | 4 |
| PCYT1A | CXXC1 | 0.783911 | 3 | 0 | 3 |
| PCYT1A | CHML | 0.780799 | 3 | 0 | 3 |
| PCYT1A | RAPGEF4 | 0.757359 | 3 | 0 | 3 |
| PCYT1A | SLC39A3 | 0.755966 | 3 | 0 | 3 |
| PCYT1A | CRTC2 | 0.751136 | 4 | 0 | 4 |
| PCYT1A | NUP133 | 0.744409 | 3 | 0 | 3 |
| PCYT1A | MRPL36 | 0.744271 | 4 | 0 | 4 |
| PCYT1A | ZBED1 | 0.742576 | 3 | 0 | 3 |
| PCYT1A | TRIM59 | 0.734761 | 5 | 0 | 5 |
| PCYT1A | TSEN34 | 0.734075 | 3 | 0 | 3 |
| PCYT1A | CEP41 | 0.730883 | 3 | 0 | 3 |
| PCYT1A | INHBB | 0.725649 | 4 | 0 | 4 |
| PCYT1A | RIOK1 | 0.725467 | 5 | 0 | 4 |
| PCYT1A | TRAF7 | 0.724785 | 4 | 0 | 4 |
For details and further investigation, click here
