| Full name: cytochrome P450 family 11 subfamily A member 1 | Alias Symbol: P450SCC | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 1583 | HGNC ID: HGNC:2590 | Ensembl Gene: ENSG00000140459 | OMIM ID: 118485 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP11A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP11A1 | 1583 | 204309_at | -1.2996 | 0.0132 | |
| GSE20347 | CYP11A1 | 1583 | 204309_at | -1.0853 | 0.0000 | |
| GSE23400 | CYP11A1 | 1583 | 204309_at | -0.5322 | 0.0000 | |
| GSE26886 | CYP11A1 | 1583 | 204309_at | -1.3968 | 0.0000 | |
| GSE29001 | CYP11A1 | 1583 | 204309_at | -0.8898 | 0.0000 | |
| GSE38129 | CYP11A1 | 1583 | 204309_at | -0.8902 | 0.0000 | |
| GSE45670 | CYP11A1 | 1583 | 204309_at | -0.3636 | 0.0466 | |
| GSE53622 | CYP11A1 | 1583 | 87879 | -1.4020 | 0.0000 | |
| GSE53624 | CYP11A1 | 1583 | 87879 | -1.5243 | 0.0000 | |
| GSE63941 | CYP11A1 | 1583 | 204309_at | -0.5692 | 0.0286 | |
| GSE77861 | CYP11A1 | 1583 | 204309_at | -0.6554 | 0.0119 | |
| GSE97050 | CYP11A1 | 1583 | A_23_P129169 | -0.4761 | 0.6212 | |
| SRP064894 | CYP11A1 | 1583 | RNAseq | -2.2600 | 0.0001 | |
| SRP133303 | CYP11A1 | 1583 | RNAseq | -3.6455 | 0.0000 | |
| SRP159526 | CYP11A1 | 1583 | RNAseq | -3.4946 | 0.0001 | |
| SRP219564 | CYP11A1 | 1583 | RNAseq | -2.4783 | 0.0096 | |
| TCGA | CYP11A1 | 1583 | RNAseq | -0.8380 | 0.2436 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by CYP11A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP11A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP11A1 | 1583 | 9 | 0 | 21 | |
| GSE20123 | CYP11A1 | 1583 | 9 | 0 | 21 | |
| GSE43470 | CYP11A1 | 1583 | 4 | 7 | 32 | |
| GSE46452 | CYP11A1 | 1583 | 3 | 7 | 49 | |
| GSE47630 | CYP11A1 | 1583 | 8 | 10 | 22 | |
| GSE54993 | CYP11A1 | 1583 | 5 | 6 | 59 | |
| GSE54994 | CYP11A1 | 1583 | 5 | 7 | 41 | |
| GSE60625 | CYP11A1 | 1583 | 4 | 0 | 7 | |
| GSE74703 | CYP11A1 | 1583 | 4 | 4 | 28 | |
| GSE74704 | CYP11A1 | 1583 | 5 | 0 | 15 | |
| TCGA | CYP11A1 | 1583 | 13 | 15 | 68 |
Total number of gains: 69; Total number of losses: 56; Total Number of normals: 363.
Somatic mutations of CYP11A1:
Generating mutation plots.
Highly correlated genes for CYP11A1:
Showing top 20/909 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP11A1 | RNF222 | 0.84217 | 3 | 0 | 3 |
| CYP11A1 | NCCRP1 | 0.764739 | 3 | 0 | 3 |
| CYP11A1 | CXCR2 | 0.76214 | 10 | 0 | 10 |
| CYP11A1 | KPRP | 0.75919 | 3 | 0 | 3 |
| CYP11A1 | IQCF1 | 0.755603 | 4 | 0 | 4 |
| CYP11A1 | NOTO | 0.746796 | 3 | 0 | 3 |
| CYP11A1 | FAM163B | 0.745568 | 3 | 0 | 3 |
| CYP11A1 | MFSD2B | 0.743626 | 3 | 0 | 3 |
| CYP11A1 | FCHO2 | 0.741301 | 6 | 0 | 6 |
| CYP11A1 | MUC22 | 0.740723 | 3 | 0 | 3 |
| CYP11A1 | SPINK7 | 0.739453 | 7 | 0 | 7 |
| CYP11A1 | CYSRT1 | 0.738752 | 6 | 0 | 6 |
| CYP11A1 | CRISP3 | 0.738674 | 10 | 0 | 10 |
| CYP11A1 | RASSF5 | 0.728553 | 5 | 0 | 5 |
| CYP11A1 | SASH1 | 0.728132 | 11 | 0 | 11 |
| CYP11A1 | CAPN14 | 0.727598 | 6 | 0 | 6 |
| CYP11A1 | HCG27 | 0.725985 | 3 | 0 | 3 |
| CYP11A1 | ECM1 | 0.724996 | 12 | 0 | 12 |
| CYP11A1 | VSIG10L | 0.723027 | 7 | 0 | 7 |
| CYP11A1 | ASPG | 0.718035 | 5 | 0 | 5 |
For details and further investigation, click here
