| Full name: cytochrome P450 family 1 subfamily B member 1 | Alias Symbol: CP1B | ||
| Type: protein-coding gene | Cytoband: 2p22.2 | ||
| Entrez ID: 1545 | HGNC ID: HGNC:2597 | Ensembl Gene: ENSG00000138061 | OMIM ID: 601771 |
| Related drugs: AMINOGLUTETHIMIDE, ANASTROZOLE, CHRYSIN, EXEMESTANE, FADROZOLE, FORMESTANE, ISOPROPYL ALCOHOL, LETROZOLE, MEDROXYPROGESTERONE ACETATE, RIFAMPICIN... [more] | |||
Expression of CYP1B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP1B1 | 1545 | 202436_s_at | -0.1684 | 0.8896 | |
| GSE20347 | CYP1B1 | 1545 | 202436_s_at | -1.0885 | 0.0407 | |
| GSE23400 | CYP1B1 | 1545 | 202436_s_at | -0.0998 | 0.5981 | |
| GSE26886 | CYP1B1 | 1545 | 202436_s_at | 1.4866 | 0.0111 | |
| GSE29001 | CYP1B1 | 1545 | 202436_s_at | -1.0894 | 0.1670 | |
| GSE38129 | CYP1B1 | 1545 | 202436_s_at | -0.8293 | 0.0957 | |
| GSE45670 | CYP1B1 | 1545 | 202436_s_at | -2.2719 | 0.0000 | |
| GSE53622 | CYP1B1 | 1545 | 24316 | -0.5169 | 0.0203 | |
| GSE53624 | CYP1B1 | 1545 | 24316 | -0.5611 | 0.0013 | |
| GSE63941 | CYP1B1 | 1545 | 202436_s_at | -3.5992 | 0.0182 | |
| GSE77861 | CYP1B1 | 1545 | 202435_s_at | 0.1650 | 0.2711 | |
| GSE97050 | CYP1B1 | 1545 | A_23_P209625 | 0.6587 | 0.2729 | |
| SRP007169 | CYP1B1 | 1545 | RNAseq | 1.6894 | 0.0293 | |
| SRP064894 | CYP1B1 | 1545 | RNAseq | 1.3098 | 0.0116 | |
| SRP133303 | CYP1B1 | 1545 | RNAseq | 0.1631 | 0.7400 | |
| SRP159526 | CYP1B1 | 1545 | RNAseq | -0.2629 | 0.6715 | |
| SRP219564 | CYP1B1 | 1545 | RNAseq | 1.0631 | 0.2578 | |
| TCGA | CYP1B1 | 1545 | RNAseq | -0.7002 | 0.0021 |
Upregulated datasets: 3; Downregulated datasets: 3.
Survival by CYP1B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP1B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP1B1 | 1545 | 10 | 1 | 19 | |
| GSE20123 | CYP1B1 | 1545 | 9 | 1 | 20 | |
| GSE43470 | CYP1B1 | 1545 | 3 | 0 | 40 | |
| GSE46452 | CYP1B1 | 1545 | 1 | 4 | 54 | |
| GSE47630 | CYP1B1 | 1545 | 7 | 0 | 33 | |
| GSE54993 | CYP1B1 | 1545 | 0 | 5 | 65 | |
| GSE54994 | CYP1B1 | 1545 | 10 | 0 | 43 | |
| GSE60625 | CYP1B1 | 1545 | 0 | 3 | 8 | |
| GSE74703 | CYP1B1 | 1545 | 3 | 0 | 33 | |
| GSE74704 | CYP1B1 | 1545 | 9 | 1 | 10 | |
| TCGA | CYP1B1 | 1545 | 35 | 2 | 59 |
Total number of gains: 87; Total number of losses: 17; Total Number of normals: 384.
Somatic mutations of CYP1B1:
Generating mutation plots.
Highly correlated genes for CYP1B1:
Showing top 20/321 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP1B1 | IFITM1 | 0.718844 | 3 | 0 | 3 |
| CYP1B1 | TESK1 | 0.703302 | 3 | 0 | 3 |
| CYP1B1 | PIP4K2A | 0.685306 | 4 | 0 | 4 |
| CYP1B1 | RAB11FIP2 | 0.677714 | 3 | 0 | 3 |
| CYP1B1 | RAC2 | 0.647127 | 3 | 0 | 3 |
| CYP1B1 | IFNGR1 | 0.645424 | 3 | 0 | 3 |
| CYP1B1 | MPEG1 | 0.643225 | 4 | 0 | 4 |
| CYP1B1 | PCGF5 | 0.642351 | 5 | 0 | 4 |
| CYP1B1 | TNFSF13 | 0.637181 | 4 | 0 | 3 |
| CYP1B1 | UHRF1BP1 | 0.636117 | 3 | 0 | 3 |
| CYP1B1 | EXT2 | 0.636004 | 3 | 0 | 3 |
| CYP1B1 | MED22 | 0.633682 | 4 | 0 | 4 |
| CYP1B1 | TNFSF8 | 0.624876 | 4 | 0 | 3 |
| CYP1B1 | RPL19 | 0.620962 | 3 | 0 | 3 |
| CYP1B1 | KLHL13 | 0.620515 | 3 | 0 | 3 |
| CYP1B1 | PREX1 | 0.620144 | 4 | 0 | 3 |
| CYP1B1 | ECSCR | 0.618768 | 4 | 0 | 3 |
| CYP1B1 | GFM1 | 0.616548 | 3 | 0 | 3 |
| CYP1B1 | KCNT2 | 0.615955 | 6 | 0 | 5 |
| CYP1B1 | FAM124A | 0.615204 | 4 | 0 | 3 |
For details and further investigation, click here
