| Full name: phosphatidylinositol-5-phosphate 4-kinase type 2 alpha | Alias Symbol: PIP5KIIA|PIP5KIIalpha | ||
| Type: protein-coding gene | Cytoband: 10p12.2 | ||
| Entrez ID: 5305 | HGNC ID: HGNC:8997 | Ensembl Gene: ENSG00000150867 | OMIM ID: 603140 |
| Drug and gene relationship at DGIdb | |||
PIP4K2A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
Expression of PIP4K2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PIP4K2A | 5305 | 212829_at | -0.2710 | 0.7016 | |
| GSE20347 | PIP4K2A | 5305 | 212829_at | -0.2067 | 0.0983 | |
| GSE23400 | PIP4K2A | 5305 | 212829_at | 0.0183 | 0.8385 | |
| GSE26886 | PIP4K2A | 5305 | 212829_at | -0.5358 | 0.0266 | |
| GSE29001 | PIP4K2A | 5305 | 212829_at | 0.2297 | 0.3813 | |
| GSE38129 | PIP4K2A | 5305 | 212829_at | -0.3942 | 0.0257 | |
| GSE45670 | PIP4K2A | 5305 | 212829_at | -0.7046 | 0.0006 | |
| GSE63941 | PIP4K2A | 5305 | 212829_at | -0.7471 | 0.0966 | |
| GSE77861 | PIP4K2A | 5305 | 212829_at | -0.0311 | 0.9075 | |
| GSE97050 | PIP4K2A | 5305 | A_33_P3394065 | 0.4211 | 0.2781 | |
| SRP007169 | PIP4K2A | 5305 | RNAseq | 0.7401 | 0.1301 | |
| SRP008496 | PIP4K2A | 5305 | RNAseq | 0.9920 | 0.0028 | |
| SRP064894 | PIP4K2A | 5305 | RNAseq | 0.0238 | 0.8990 | |
| SRP133303 | PIP4K2A | 5305 | RNAseq | -0.1885 | 0.2575 | |
| SRP159526 | PIP4K2A | 5305 | RNAseq | -0.4598 | 0.3856 | |
| SRP193095 | PIP4K2A | 5305 | RNAseq | -0.0075 | 0.9551 | |
| SRP219564 | PIP4K2A | 5305 | RNAseq | -0.0882 | 0.8047 | |
| TCGA | PIP4K2A | 5305 | RNAseq | -0.1691 | 0.0067 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PIP4K2A expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PIP4K2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PIP4K2A | 5305 | 4 | 8 | 18 | |
| GSE20123 | PIP4K2A | 5305 | 4 | 7 | 19 | |
| GSE43470 | PIP4K2A | 5305 | 4 | 4 | 35 | |
| GSE46452 | PIP4K2A | 5305 | 1 | 14 | 44 | |
| GSE47630 | PIP4K2A | 5305 | 5 | 15 | 20 | |
| GSE54993 | PIP4K2A | 5305 | 10 | 0 | 60 | |
| GSE54994 | PIP4K2A | 5305 | 3 | 9 | 41 | |
| GSE60625 | PIP4K2A | 5305 | 0 | 0 | 11 | |
| GSE74703 | PIP4K2A | 5305 | 3 | 2 | 31 | |
| GSE74704 | PIP4K2A | 5305 | 0 | 6 | 14 | |
| TCGA | PIP4K2A | 5305 | 18 | 25 | 53 |
Total number of gains: 52; Total number of losses: 90; Total Number of normals: 346.
Somatic mutations of PIP4K2A:
Generating mutation plots.
Highly correlated genes for PIP4K2A:
Showing top 20/581 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PIP4K2A | GBGT1 | 0.782924 | 3 | 0 | 3 |
| PIP4K2A | GIMAP1 | 0.779378 | 3 | 0 | 3 |
| PIP4K2A | SLITRK6 | 0.764872 | 3 | 0 | 3 |
| PIP4K2A | WDFY1 | 0.731551 | 3 | 0 | 3 |
| PIP4K2A | KCNA3 | 0.729104 | 3 | 0 | 3 |
| PIP4K2A | SPON1 | 0.724267 | 5 | 0 | 5 |
| PIP4K2A | FLI1 | 0.717508 | 6 | 0 | 5 |
| PIP4K2A | GIMAP6 | 0.717315 | 7 | 0 | 7 |
| PIP4K2A | SMAP2 | 0.714798 | 4 | 0 | 4 |
| PIP4K2A | BTN2A2 | 0.710147 | 3 | 0 | 3 |
| PIP4K2A | C1orf162 | 0.709934 | 4 | 0 | 3 |
| PIP4K2A | FAM107B | 0.706496 | 3 | 0 | 3 |
| PIP4K2A | TRMT5 | 0.701115 | 3 | 0 | 3 |
| PIP4K2A | EPS8 | 0.696161 | 4 | 0 | 4 |
| PIP4K2A | TGM2 | 0.691301 | 7 | 0 | 6 |
| PIP4K2A | NFATC2 | 0.690863 | 4 | 0 | 3 |
| PIP4K2A | ZRANB2 | 0.687874 | 5 | 0 | 5 |
| PIP4K2A | RCSD1 | 0.686928 | 5 | 0 | 4 |
| PIP4K2A | DPY19L3 | 0.685362 | 3 | 0 | 3 |
| PIP4K2A | CYP1B1 | 0.685306 | 4 | 0 | 4 |
For details and further investigation, click here
