| Full name: G elongation factor mitochondrial 1 | Alias Symbol: EFGM|GFM|EGF1|mtEF-G1 | ||
| Type: protein-coding gene | Cytoband: 3q25.32 | ||
| Entrez ID: 85476 | HGNC ID: HGNC:13780 | Ensembl Gene: ENSG00000168827 | OMIM ID: 606639 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GFM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GFM1 | 85476 | 225153_at | 0.6878 | 0.0770 | |
| GSE20347 | GFM1 | 85476 | 220903_at | 0.0160 | 0.7780 | |
| GSE23400 | GFM1 | 85476 | 220903_at | -0.0891 | 0.0154 | |
| GSE26886 | GFM1 | 85476 | 225153_at | 0.6514 | 0.0012 | |
| GSE29001 | GFM1 | 85476 | 220903_at | 0.0059 | 0.9744 | |
| GSE38129 | GFM1 | 85476 | 220903_at | 0.0190 | 0.7182 | |
| GSE45670 | GFM1 | 85476 | 225153_at | 0.2805 | 0.1738 | |
| GSE53622 | GFM1 | 85476 | 9035 | 0.7931 | 0.0000 | |
| GSE53624 | GFM1 | 85476 | 9035 | 1.0335 | 0.0000 | |
| GSE63941 | GFM1 | 85476 | 225153_at | 0.1651 | 0.7530 | |
| GSE77861 | GFM1 | 85476 | 225153_at | 0.8524 | 0.0226 | |
| GSE97050 | GFM1 | 85476 | A_23_P155288 | 0.5719 | 0.1659 | |
| SRP007169 | GFM1 | 85476 | RNAseq | 0.9858 | 0.0040 | |
| SRP008496 | GFM1 | 85476 | RNAseq | 1.0965 | 0.0000 | |
| SRP064894 | GFM1 | 85476 | RNAseq | 0.6446 | 0.0005 | |
| SRP133303 | GFM1 | 85476 | RNAseq | 0.9750 | 0.0000 | |
| SRP159526 | GFM1 | 85476 | RNAseq | 1.2498 | 0.0002 | |
| SRP193095 | GFM1 | 85476 | RNAseq | 0.6691 | 0.0000 | |
| SRP219564 | GFM1 | 85476 | RNAseq | 0.6517 | 0.1135 | |
| TCGA | GFM1 | 85476 | RNAseq | 0.1016 | 0.0387 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by GFM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GFM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GFM1 | 85476 | 22 | 0 | 8 | |
| GSE20123 | GFM1 | 85476 | 22 | 0 | 8 | |
| GSE43470 | GFM1 | 85476 | 23 | 0 | 20 | |
| GSE46452 | GFM1 | 85476 | 18 | 2 | 39 | |
| GSE47630 | GFM1 | 85476 | 18 | 4 | 18 | |
| GSE54993 | GFM1 | 85476 | 1 | 11 | 58 | |
| GSE54994 | GFM1 | 85476 | 38 | 1 | 14 | |
| GSE60625 | GFM1 | 85476 | 0 | 6 | 5 | |
| GSE74703 | GFM1 | 85476 | 20 | 0 | 16 | |
| GSE74704 | GFM1 | 85476 | 14 | 0 | 6 | |
| TCGA | GFM1 | 85476 | 75 | 1 | 20 |
Total number of gains: 251; Total number of losses: 25; Total Number of normals: 212.
Somatic mutations of GFM1:
Generating mutation plots.
Highly correlated genes for GFM1:
Showing top 20/1233 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GFM1 | IKZF3 | 0.776516 | 3 | 0 | 3 |
| GFM1 | LRRC58 | 0.760768 | 5 | 0 | 5 |
| GFM1 | RBL1 | 0.760746 | 4 | 0 | 4 |
| GFM1 | IFNA5 | 0.755042 | 3 | 0 | 3 |
| GFM1 | FANCB | 0.749702 | 4 | 0 | 4 |
| GFM1 | CENPQ | 0.738137 | 4 | 0 | 3 |
| GFM1 | CKAP2L | 0.730595 | 5 | 0 | 5 |
| GFM1 | PYCR2 | 0.725605 | 3 | 0 | 3 |
| GFM1 | FAM89A | 0.725107 | 3 | 0 | 3 |
| GFM1 | KIF2C | 0.719893 | 5 | 0 | 4 |
| GFM1 | MMS22L | 0.719275 | 3 | 0 | 3 |
| GFM1 | RRAS2 | 0.718974 | 4 | 0 | 4 |
| GFM1 | NOLC1 | 0.718875 | 5 | 0 | 4 |
| GFM1 | RFC4 | 0.717935 | 8 | 0 | 8 |
| GFM1 | RRP36 | 0.712598 | 4 | 0 | 3 |
| GFM1 | SNAP47 | 0.710447 | 4 | 0 | 4 |
| GFM1 | RAN | 0.710413 | 5 | 0 | 4 |
| GFM1 | SLC13A1 | 0.706912 | 3 | 0 | 3 |
| GFM1 | CACYBP | 0.705795 | 7 | 0 | 6 |
| GFM1 | FADD | 0.705172 | 4 | 0 | 3 |
For details and further investigation, click here
