RAC2

 

Full name: Rac family small GTPase 2 Alias Symbol: EN-7
Type: protein-coding gene Cytoband: 22q13.1
Entrez ID: 5880 HGNC ID: HGNC:9802 Ensembl Gene: ENSG00000128340 OMIM ID: 602049
Drug and gene relationship at DGIdb

 

RAC2 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04650Natural killer cell mediated cytotoxicity
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05231Choline metabolism in cancer

 

Expression of RAC2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RAC2 5880 213603_s_at 0.7590 0.4280
GSE20347 RAC2 5880 213603_s_at 0.5391 0.0553
GSE23400 RAC2 5880 213603_s_at 0.5129 0.0000
GSE26886 RAC2 5880 213603_s_at 0.8130 0.0770
GSE29001 RAC2 5880 213603_s_at 0.7187 0.0362
GSE38129 RAC2 5880 213603_s_at 0.5366 0.0612
GSE45670 RAC2 5880 213603_s_at 0.7102 0.0258
GSE53622 RAC2 5880 13822 0.8341 0.0000
GSE53624 RAC2 5880 13822 0.6115 0.0000
GSE63941 RAC2 5880 213603_s_at 1.3251 0.2171
GSE77861 RAC2 5880 213603_s_at 0.8575 0.0219
GSE97050 RAC2 5880 A_23_P218770 1.2813 0.1235
SRP007169 RAC2 5880 RNAseq 2.0127 0.0135
SRP008496 RAC2 5880 RNAseq 1.3351 0.0121
SRP064894 RAC2 5880 RNAseq 1.4673 0.0000
SRP133303 RAC2 5880 RNAseq 0.2809 0.2544
SRP159526 RAC2 5880 RNAseq -0.2114 0.7773
SRP193095 RAC2 5880 RNAseq 1.1037 0.0000
SRP219564 RAC2 5880 RNAseq 1.9427 0.0072
TCGA RAC2 5880 RNAseq 0.5615 0.0000

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by RAC2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RAC2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RAC2 5880 6 6 18
GSE20123 RAC2 5880 6 5 19
GSE43470 RAC2 5880 4 6 33
GSE46452 RAC2 5880 31 1 27
GSE47630 RAC2 5880 8 5 27
GSE54993 RAC2 5880 3 6 61
GSE54994 RAC2 5880 10 8 35
GSE60625 RAC2 5880 5 0 6
GSE74703 RAC2 5880 4 4 28
GSE74704 RAC2 5880 3 2 15
TCGA RAC2 5880 27 16 53

Total number of gains: 107; Total number of losses: 59; Total Number of normals: 322.  

 

Somatic mutations of RAC2:

 

Generating mutation plots.

 

Highly correlated genes for RAC2:

 

Showing top 20/849 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RAC2PREX10.771095303
RAC2RUNX20.746199606
RAC2COTL10.729528707
RAC2SNX200.718227404
RAC2GTF3C30.716535303
RAC2TBC1D20.712898303
RAC2USP50.707807303
RAC2ALPK20.704428303
RAC2LILRB10.701458504
RAC2CD300C0.687245504
RAC2FKBP110.687203706
RAC2TCL1A0.681538303
RAC2CMTM70.677636504
RAC2TPM30.677068605
RAC2PCED1B0.676026707
RAC2RAB33A0.67566505
RAC2KLHL60.674069504
RAC2CYBA0.670172706
RAC2VMA210.668344403
RAC2NRIP10.662416303

For details and further investigation, click here