| Full name: gamma-aminobutyric acid type A receptor beta2 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q34 | ||
| Entrez ID: 2561 | HGNC ID: HGNC:4082 | Ensembl Gene: ENSG00000145864 | OMIM ID: 600232 |
| Drug and gene relationship at DGIdb | |||
GABRB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa05032 | Morphine addiction |
Expression of GABRB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRB2 | 2561 | 207352_s_at | 0.0148 | 0.9518 | |
| GSE20347 | GABRB2 | 2561 | 207352_s_at | 0.0696 | 0.4734 | |
| GSE23400 | GABRB2 | 2561 | 207352_s_at | -0.0923 | 0.0416 | |
| GSE26886 | GABRB2 | 2561 | 207352_s_at | 0.1552 | 0.2759 | |
| GSE29001 | GABRB2 | 2561 | 207352_s_at | -0.0758 | 0.6252 | |
| GSE38129 | GABRB2 | 2561 | 207352_s_at | -0.1040 | 0.3936 | |
| GSE45670 | GABRB2 | 2561 | 207352_s_at | 0.0055 | 0.9604 | |
| GSE53622 | GABRB2 | 2561 | 27332 | -0.0890 | 0.7464 | |
| GSE53624 | GABRB2 | 2561 | 27332 | -0.1450 | 0.4910 | |
| GSE63941 | GABRB2 | 2561 | 207352_s_at | 0.3959 | 0.0066 | |
| GSE77861 | GABRB2 | 2561 | 207352_s_at | -0.0042 | 0.9785 | |
| SRP133303 | GABRB2 | 2561 | RNAseq | 1.9846 | 0.0042 | |
| TCGA | GABRB2 | 2561 | RNAseq | -1.6479 | 0.0059 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by GABRB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GABRB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRB2 | 2561 | 0 | 12 | 18 | |
| GSE20123 | GABRB2 | 2561 | 0 | 12 | 18 | |
| GSE43470 | GABRB2 | 2561 | 2 | 10 | 31 | |
| GSE46452 | GABRB2 | 2561 | 0 | 27 | 32 | |
| GSE47630 | GABRB2 | 2561 | 0 | 20 | 20 | |
| GSE54993 | GABRB2 | 2561 | 9 | 2 | 59 | |
| GSE54994 | GABRB2 | 2561 | 2 | 15 | 36 | |
| GSE60625 | GABRB2 | 2561 | 0 | 0 | 11 | |
| GSE74703 | GABRB2 | 2561 | 2 | 8 | 26 | |
| GSE74704 | GABRB2 | 2561 | 0 | 7 | 13 | |
| TCGA | GABRB2 | 2561 | 5 | 37 | 54 |
Total number of gains: 20; Total number of losses: 150; Total Number of normals: 318.
Somatic mutations of GABRB2:
Generating mutation plots.
Highly correlated genes for GABRB2:
Showing top 20/694 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRB2 | LUZP4 | 0.746871 | 5 | 0 | 5 |
| GABRB2 | CYP2A7 | 0.744215 | 4 | 0 | 4 |
| GABRB2 | ODF1 | 0.738332 | 4 | 0 | 4 |
| GABRB2 | KCNJ10 | 0.736472 | 4 | 0 | 4 |
| GABRB2 | SYT13 | 0.720541 | 3 | 0 | 3 |
| GABRB2 | FOLH1 | 0.714102 | 4 | 0 | 4 |
| GABRB2 | GAD2 | 0.713854 | 4 | 0 | 4 |
| GABRB2 | KIR2DS5 | 0.709037 | 4 | 0 | 3 |
| GABRB2 | ATN1 | 0.707396 | 5 | 0 | 5 |
| GABRB2 | HAL | 0.697871 | 6 | 0 | 5 |
| GABRB2 | CHST4 | 0.691013 | 5 | 0 | 5 |
| GABRB2 | RAB3IL1 | 0.69024 | 6 | 0 | 5 |
| GABRB2 | CPNE6 | 0.689461 | 5 | 0 | 4 |
| GABRB2 | NXPE4 | 0.688004 | 6 | 0 | 6 |
| GABRB2 | RGSL1 | 0.686747 | 4 | 0 | 4 |
| GABRB2 | ART1 | 0.685492 | 5 | 0 | 5 |
| GABRB2 | CPA2 | 0.685425 | 4 | 0 | 3 |
| GABRB2 | FGR | 0.685004 | 3 | 0 | 3 |
| GABRB2 | CACNA1E | 0.679228 | 3 | 0 | 3 |
| GABRB2 | USP49 | 0.677078 | 4 | 0 | 4 |
For details and further investigation, click here
