| Full name: cytochrome P450 family 7 subfamily B member 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q12.3 | ||
| Entrez ID: 9420 | HGNC ID: HGNC:2652 | Ensembl Gene: ENSG00000172817 | OMIM ID: 603711 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP7B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP7B1 | 9420 | 207386_at | 0.7348 | 0.5156 | |
| GSE20347 | CYP7B1 | 9420 | 207386_at | -0.7404 | 0.0028 | |
| GSE23400 | CYP7B1 | 9420 | 207386_at | -0.1237 | 0.0042 | |
| GSE26886 | CYP7B1 | 9420 | 207386_at | -1.5253 | 0.0001 | |
| GSE29001 | CYP7B1 | 9420 | 207386_at | -0.7680 | 0.1425 | |
| GSE38129 | CYP7B1 | 9420 | 207386_at | -0.4140 | 0.0812 | |
| GSE45670 | CYP7B1 | 9420 | 207386_at | -0.0273 | 0.9435 | |
| GSE53622 | CYP7B1 | 9420 | 48277 | -0.8178 | 0.0000 | |
| GSE53624 | CYP7B1 | 9420 | 48277 | -1.1191 | 0.0000 | |
| GSE63941 | CYP7B1 | 9420 | 207386_at | 0.1305 | 0.8545 | |
| GSE77861 | CYP7B1 | 9420 | 207386_at | -0.4837 | 0.0135 | |
| GSE97050 | CYP7B1 | 9420 | A_23_P169092 | 0.3818 | 0.3246 | |
| SRP007169 | CYP7B1 | 9420 | RNAseq | -2.0799 | 0.0000 | |
| SRP008496 | CYP7B1 | 9420 | RNAseq | -1.7027 | 0.0000 | |
| SRP064894 | CYP7B1 | 9420 | RNAseq | -0.4125 | 0.2198 | |
| SRP133303 | CYP7B1 | 9420 | RNAseq | -0.5429 | 0.0938 | |
| SRP159526 | CYP7B1 | 9420 | RNAseq | -0.9009 | 0.0134 | |
| SRP193095 | CYP7B1 | 9420 | RNAseq | -1.0797 | 0.0002 | |
| SRP219564 | CYP7B1 | 9420 | RNAseq | -0.2773 | 0.5313 | |
| TCGA | CYP7B1 | 9420 | RNAseq | -0.3173 | 0.1563 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by CYP7B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP7B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP7B1 | 9420 | 12 | 1 | 17 | |
| GSE20123 | CYP7B1 | 9420 | 12 | 1 | 17 | |
| GSE43470 | CYP7B1 | 9420 | 15 | 3 | 25 | |
| GSE46452 | CYP7B1 | 9420 | 21 | 1 | 37 | |
| GSE47630 | CYP7B1 | 9420 | 23 | 1 | 16 | |
| GSE54993 | CYP7B1 | 9420 | 1 | 18 | 51 | |
| GSE54994 | CYP7B1 | 9420 | 30 | 0 | 23 | |
| GSE60625 | CYP7B1 | 9420 | 0 | 4 | 7 | |
| GSE74703 | CYP7B1 | 9420 | 13 | 2 | 21 | |
| GSE74704 | CYP7B1 | 9420 | 8 | 0 | 12 | |
| TCGA | CYP7B1 | 9420 | 47 | 5 | 44 |
Total number of gains: 182; Total number of losses: 36; Total Number of normals: 270.
Somatic mutations of CYP7B1:
Generating mutation plots.
Highly correlated genes for CYP7B1:
Showing top 20/611 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP7B1 | MOV10 | 0.724414 | 4 | 0 | 4 |
| CYP7B1 | SH3BP2 | 0.703621 | 3 | 0 | 3 |
| CYP7B1 | ACTR3C | 0.690975 | 5 | 0 | 5 |
| CYP7B1 | RNF149 | 0.685576 | 3 | 0 | 3 |
| CYP7B1 | TMEM234 | 0.68438 | 3 | 0 | 3 |
| CYP7B1 | AKT2 | 0.680247 | 3 | 0 | 3 |
| CYP7B1 | COMMD5 | 0.672952 | 3 | 0 | 3 |
| CYP7B1 | UBE2V2 | 0.669685 | 3 | 0 | 3 |
| CYP7B1 | ZNF468 | 0.668531 | 4 | 0 | 3 |
| CYP7B1 | PARP4 | 0.665037 | 4 | 0 | 4 |
| CYP7B1 | MAP7 | 0.660955 | 3 | 0 | 3 |
| CYP7B1 | LRP11 | 0.657959 | 4 | 0 | 4 |
| CYP7B1 | RASSF5 | 0.656825 | 6 | 0 | 5 |
| CYP7B1 | GK | 0.654692 | 4 | 0 | 4 |
| CYP7B1 | TMBIM6 | 0.652106 | 4 | 0 | 3 |
| CYP7B1 | COX16 | 0.652042 | 3 | 0 | 3 |
| CYP7B1 | PSMC6 | 0.645234 | 3 | 0 | 3 |
| CYP7B1 | TMPRSS13 | 0.642714 | 3 | 0 | 3 |
| CYP7B1 | UNC5B | 0.641629 | 4 | 0 | 3 |
| CYP7B1 | ZNF718 | 0.64135 | 3 | 0 | 3 |
For details and further investigation, click here
