| Full name: transmembrane serine protease 13 | Alias Symbol: MSPL | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 84000 | HGNC ID: HGNC:29808 | Ensembl Gene: ENSG00000137747 | OMIM ID: 610050 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TMPRSS13:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMPRSS13 | 84000 | 223659_at | 0.2258 | 0.7266 | |
| GSE26886 | TMPRSS13 | 84000 | 223659_at | -0.7676 | 0.0000 | |
| GSE45670 | TMPRSS13 | 84000 | 223659_at | 0.5888 | 0.0054 | |
| GSE53622 | TMPRSS13 | 84000 | 84880 | -0.3298 | 0.1701 | |
| GSE53624 | TMPRSS13 | 84000 | 84880 | -0.5626 | 0.0001 | |
| GSE63941 | TMPRSS13 | 84000 | 223659_at | 0.4342 | 0.2976 | |
| GSE77861 | TMPRSS13 | 84000 | 223659_at | 0.1380 | 0.5504 | |
| GSE97050 | TMPRSS13 | A_21_P0000169 | 0.1913 | 0.3527 | ||
| SRP007169 | TMPRSS13 | 84000 | RNAseq | -2.8255 | 0.0000 | |
| SRP008496 | TMPRSS13 | 84000 | RNAseq | -2.2677 | 0.0000 | |
| SRP064894 | TMPRSS13 | 84000 | RNAseq | -1.3357 | 0.0004 | |
| SRP133303 | TMPRSS13 | 84000 | RNAseq | -0.9575 | 0.0002 | |
| SRP159526 | TMPRSS13 | 84000 | RNAseq | -1.3879 | 0.0043 | |
| SRP219564 | TMPRSS13 | 84000 | RNAseq | -2.2592 | 0.0152 | |
| TCGA | TMPRSS13 | 84000 | RNAseq | 1.5519 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by TMPRSS13 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMPRSS13:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMPRSS13 | 84000 | 1 | 11 | 18 | |
| GSE20123 | TMPRSS13 | 84000 | 1 | 11 | 18 | |
| GSE43470 | TMPRSS13 | 84000 | 2 | 9 | 32 | |
| GSE46452 | TMPRSS13 | 84000 | 3 | 26 | 30 | |
| GSE47630 | TMPRSS13 | 84000 | 2 | 19 | 19 | |
| GSE54993 | TMPRSS13 | 84000 | 10 | 0 | 60 | |
| GSE54994 | TMPRSS13 | 84000 | 5 | 19 | 29 | |
| GSE60625 | TMPRSS13 | 84000 | 0 | 3 | 8 | |
| GSE74703 | TMPRSS13 | 84000 | 1 | 6 | 29 | |
| GSE74704 | TMPRSS13 | 84000 | 0 | 7 | 13 | |
| TCGA | TMPRSS13 | 84000 | 5 | 50 | 41 |
Total number of gains: 30; Total number of losses: 161; Total Number of normals: 297.
Somatic mutations of TMPRSS13:
Generating mutation plots.
Highly correlated genes for TMPRSS13:
Showing top 20/327 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMPRSS13 | SPAG17 | 0.704612 | 3 | 0 | 3 |
| TMPRSS13 | DHCR24 | 0.703828 | 3 | 0 | 3 |
| TMPRSS13 | E2F2 | 0.682339 | 3 | 0 | 3 |
| TMPRSS13 | TGM1 | 0.671017 | 4 | 0 | 3 |
| TMPRSS13 | SLC39A2 | 0.662834 | 5 | 0 | 5 |
| TMPRSS13 | ANO8 | 0.662523 | 4 | 0 | 3 |
| TMPRSS13 | RAB7B | 0.662501 | 3 | 0 | 3 |
| TMPRSS13 | RAB3D | 0.655787 | 4 | 0 | 4 |
| TMPRSS13 | PRR15L | 0.654805 | 3 | 0 | 3 |
| TMPRSS13 | STYXL1 | 0.654333 | 3 | 0 | 3 |
| TMPRSS13 | STT3A | 0.653876 | 3 | 0 | 3 |
| TMPRSS13 | APH1A | 0.652831 | 3 | 0 | 3 |
| TMPRSS13 | PGM2 | 0.647764 | 5 | 0 | 4 |
| TMPRSS13 | PRKCH | 0.647485 | 4 | 0 | 3 |
| TMPRSS13 | ZNF654 | 0.646592 | 3 | 0 | 3 |
| TMPRSS13 | SMPDL3A | 0.643502 | 3 | 0 | 3 |
| TMPRSS13 | CYP7B1 | 0.642714 | 3 | 0 | 3 |
| TMPRSS13 | MREG | 0.642678 | 5 | 0 | 4 |
| TMPRSS13 | MPZL2 | 0.640163 | 4 | 0 | 3 |
| TMPRSS13 | TST | 0.639603 | 4 | 0 | 3 |
For details and further investigation, click here
