| Full name: EPH receptor A6 | Alias Symbol: FLJ35246 | ||
| Type: protein-coding gene | Cytoband: 3q11.2 | ||
| Entrez ID: 285220 | HGNC ID: HGNC:19296 | Ensembl Gene: ENSG00000080224 | OMIM ID: 600066 |
| Drug and gene relationship at DGIdb | |||
EPHA6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of EPHA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPHA6 | 285220 | 233184_at | -0.1147 | 0.6762 | |
| GSE26886 | EPHA6 | 285220 | 233184_at | 0.0650 | 0.4550 | |
| GSE45670 | EPHA6 | 285220 | 233184_at | -0.0261 | 0.8167 | |
| GSE53622 | EPHA6 | 285220 | 4735 | -1.1753 | 0.0000 | |
| GSE53624 | EPHA6 | 285220 | 109677 | 0.4979 | 0.0012 | |
| GSE63941 | EPHA6 | 285220 | 233184_at | 0.1808 | 0.4037 | |
| GSE77861 | EPHA6 | 285220 | 233184_at | 0.0242 | 0.8094 | |
| GSE97050 | EPHA6 | 285220 | A_33_P3408782 | -0.2513 | 0.3609 | |
| SRP007169 | EPHA6 | 285220 | RNAseq | 2.1553 | 0.0811 | |
| SRP133303 | EPHA6 | 285220 | RNAseq | -0.5693 | 0.4101 | |
| SRP193095 | EPHA6 | 285220 | RNAseq | -0.8123 | 0.0950 | |
| SRP219564 | EPHA6 | 285220 | RNAseq | -0.0600 | 0.9522 | |
| TCGA | EPHA6 | 285220 | RNAseq | -0.5669 | 0.3661 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by EPHA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPHA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPHA6 | 285220 | 20 | 1 | 9 | |
| GSE20123 | EPHA6 | 285220 | 19 | 1 | 10 | |
| GSE43470 | EPHA6 | 285220 | 18 | 1 | 24 | |
| GSE46452 | EPHA6 | 285220 | 12 | 7 | 40 | |
| GSE47630 | EPHA6 | 285220 | 16 | 6 | 18 | |
| GSE54993 | EPHA6 | 285220 | 3 | 5 | 62 | |
| GSE54994 | EPHA6 | 285220 | 27 | 5 | 21 | |
| GSE60625 | EPHA6 | 285220 | 0 | 6 | 5 | |
| GSE74703 | EPHA6 | 285220 | 14 | 1 | 21 | |
| GSE74704 | EPHA6 | 285220 | 14 | 1 | 5 | |
| TCGA | EPHA6 | 285220 | 53 | 15 | 28 |
Total number of gains: 196; Total number of losses: 49; Total Number of normals: 243.
Somatic mutations of EPHA6:
Generating mutation plots.
Highly correlated genes for EPHA6:
Showing top 20/168 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPHA6 | SMOC2 | 0.711862 | 3 | 0 | 3 |
| EPHA6 | ITGA7 | 0.704942 | 3 | 0 | 3 |
| EPHA6 | DCLK2 | 0.699766 | 3 | 0 | 3 |
| EPHA6 | TCEAL2 | 0.698925 | 3 | 0 | 3 |
| EPHA6 | ARHGEF25 | 0.698599 | 3 | 0 | 3 |
| EPHA6 | ADCY5 | 0.690597 | 4 | 0 | 4 |
| EPHA6 | RGS2 | 0.688816 | 3 | 0 | 3 |
| EPHA6 | PLP1 | 0.688699 | 3 | 0 | 3 |
| EPHA6 | PRUNE2 | 0.687514 | 3 | 0 | 3 |
| EPHA6 | CACNA1C | 0.686752 | 3 | 0 | 3 |
| EPHA6 | NLGN1 | 0.684402 | 3 | 0 | 3 |
| EPHA6 | PPP1R14A | 0.684145 | 3 | 0 | 3 |
| EPHA6 | NRXN3 | 0.678614 | 3 | 0 | 3 |
| EPHA6 | LIMS2 | 0.677675 | 3 | 0 | 3 |
| EPHA6 | FBXL7 | 0.67152 | 3 | 0 | 3 |
| EPHA6 | SGCA | 0.668289 | 3 | 0 | 3 |
| EPHA6 | CADM3 | 0.667882 | 4 | 0 | 3 |
| EPHA6 | NEXN | 0.665263 | 3 | 0 | 3 |
| EPHA6 | TNS1 | 0.664044 | 3 | 0 | 3 |
| EPHA6 | LONRF2 | 0.654991 | 3 | 0 | 3 |
For details and further investigation, click here
