| Full name: cholesterol 25-hydroxylase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q23.31 | ||
| Entrez ID: 9023 | HGNC ID: HGNC:1907 | Ensembl Gene: ENSG00000138135 | OMIM ID: 604551 |
| Drug and gene relationship at DGIdb | |||
Expression of CH25H:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CH25H | 9023 | 206932_at | -1.9479 | 0.1412 | |
| GSE20347 | CH25H | 9023 | 206932_at | -2.7200 | 0.0000 | |
| GSE23400 | CH25H | 9023 | 206932_at | -0.8280 | 0.0000 | |
| GSE26886 | CH25H | 9023 | 206932_at | -1.9808 | 0.0001 | |
| GSE29001 | CH25H | 9023 | 206932_at | -2.8468 | 0.0000 | |
| GSE38129 | CH25H | 9023 | 206932_at | -2.4472 | 0.0000 | |
| GSE45670 | CH25H | 9023 | 206932_at | -2.3234 | 0.0001 | |
| GSE53622 | CH25H | 9023 | 65425 | -2.1296 | 0.0000 | |
| GSE53624 | CH25H | 9023 | 65425 | -2.1002 | 0.0000 | |
| GSE63941 | CH25H | 9023 | 206932_at | -2.8769 | 0.0000 | |
| GSE77861 | CH25H | 9023 | 206932_at | -1.1219 | 0.0027 | |
| GSE97050 | CH25H | 9023 | A_23_P86470 | -0.4237 | 0.2946 | |
| SRP007169 | CH25H | 9023 | RNAseq | -3.0892 | 0.0000 | |
| SRP008496 | CH25H | 9023 | RNAseq | -2.1969 | 0.0000 | |
| SRP064894 | CH25H | 9023 | RNAseq | -2.1204 | 0.0000 | |
| SRP133303 | CH25H | 9023 | RNAseq | -2.1417 | 0.0000 | |
| SRP159526 | CH25H | 9023 | RNAseq | -2.7434 | 0.0002 | |
| SRP219564 | CH25H | 9023 | RNAseq | -1.8756 | 0.0260 | |
| TCGA | CH25H | 9023 | RNAseq | -0.3289 | 0.2290 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by CH25H expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CH25H:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CH25H | 9023 | 2 | 7 | 21 | |
| GSE20123 | CH25H | 9023 | 2 | 6 | 22 | |
| GSE43470 | CH25H | 9023 | 0 | 8 | 35 | |
| GSE46452 | CH25H | 9023 | 0 | 11 | 48 | |
| GSE47630 | CH25H | 9023 | 2 | 14 | 24 | |
| GSE54993 | CH25H | 9023 | 7 | 0 | 63 | |
| GSE54994 | CH25H | 9023 | 1 | 11 | 41 | |
| GSE60625 | CH25H | 9023 | 0 | 0 | 11 | |
| GSE74703 | CH25H | 9023 | 0 | 6 | 30 | |
| GSE74704 | CH25H | 9023 | 1 | 4 | 15 | |
| TCGA | CH25H | 9023 | 8 | 27 | 61 |
Total number of gains: 23; Total number of losses: 94; Total Number of normals: 371.
Somatic mutations of CH25H:
Generating mutation plots.
Highly correlated genes for CH25H:
Showing top 20/1262 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CH25H | SORCS1 | 0.755426 | 4 | 0 | 4 |
| CH25H | SHROOM3 | 0.740015 | 7 | 0 | 7 |
| CH25H | EIF4E3 | 0.733699 | 7 | 0 | 7 |
| CH25H | STBD1 | 0.733056 | 3 | 0 | 3 |
| CH25H | SNORA68 | 0.72916 | 4 | 0 | 4 |
| CH25H | RBFOX3 | 0.728591 | 3 | 0 | 3 |
| CH25H | CTTNBP2 | 0.727471 | 7 | 0 | 7 |
| CH25H | ANGPTL1 | 0.724363 | 6 | 0 | 6 |
| CH25H | CYP21A2 | 0.723075 | 3 | 0 | 3 |
| CH25H | CGNL1 | 0.719416 | 7 | 0 | 7 |
| CH25H | LRRK2 | 0.716532 | 8 | 0 | 8 |
| CH25H | BOC | 0.71596 | 7 | 0 | 7 |
| CH25H | SMDT1 | 0.712468 | 3 | 0 | 3 |
| CH25H | CLEC3B | 0.710112 | 3 | 0 | 3 |
| CH25H | DCLK2 | 0.707015 | 3 | 0 | 3 |
| CH25H | PDE4DIP | 0.70572 | 3 | 0 | 3 |
| CH25H | SCN7A | 0.699525 | 7 | 0 | 6 |
| CH25H | GPD1L | 0.696613 | 11 | 0 | 11 |
| CH25H | HPGD | 0.695356 | 11 | 0 | 11 |
| CH25H | SYNC | 0.694752 | 3 | 0 | 3 |
For details and further investigation, click here
