CSE1L

 

Full name: chromosome segregation 1 like Alias Symbol: CAS|XPO2|CSE1
Type: protein-coding gene Cytoband: 20q13.13
Entrez ID: 1434 HGNC ID: HGNC:2431 Ensembl Gene: ENSG00000124207 OMIM ID: 601342
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CSE1L:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CSE1L 1434 201112_s_at 0.9326 0.0495
GSE20347 CSE1L 1434 201112_s_at 0.7383 0.0001
GSE23400 CSE1L 1434 201112_s_at 0.9035 0.0000
GSE26886 CSE1L 1434 201112_s_at -0.1593 0.4679
GSE29001 CSE1L 1434 201111_at 0.9232 0.0001
GSE38129 CSE1L 1434 201112_s_at 0.8426 0.0000
GSE45670 CSE1L 1434 201112_s_at 0.4952 0.0027
GSE53622 CSE1L 1434 39764 0.7524 0.0000
GSE53624 CSE1L 1434 39764 0.9192 0.0000
GSE63941 CSE1L 1434 201112_s_at 1.8463 0.0002
GSE77861 CSE1L 1434 201112_s_at 0.4130 0.0938
GSE97050 CSE1L 1434 A_33_P3284029 0.5600 0.2063
SRP007169 CSE1L 1434 RNAseq 0.3040 0.3836
SRP008496 CSE1L 1434 RNAseq 0.3289 0.0815
SRP064894 CSE1L 1434 RNAseq 0.6147 0.0018
SRP133303 CSE1L 1434 RNAseq 0.7515 0.0000
SRP159526 CSE1L 1434 RNAseq 0.4459 0.0641
SRP193095 CSE1L 1434 RNAseq 0.2538 0.1085
SRP219564 CSE1L 1434 RNAseq 0.3365 0.2425
TCGA CSE1L 1434 RNAseq 0.2715 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by CSE1L expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CSE1L:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CSE1L 1434 16 2 12
GSE20123 CSE1L 1434 16 2 12
GSE43470 CSE1L 1434 12 0 31
GSE46452 CSE1L 1434 29 0 30
GSE47630 CSE1L 1434 24 1 15
GSE54993 CSE1L 1434 0 18 52
GSE54994 CSE1L 1434 26 0 27
GSE60625 CSE1L 1434 0 0 11
GSE74703 CSE1L 1434 10 0 26
GSE74704 CSE1L 1434 12 0 8
TCGA CSE1L 1434 45 4 47

Total number of gains: 190; Total number of losses: 27; Total Number of normals: 271.  

 

Somatic mutations of CSE1L:

 

Generating mutation plots.

 

Highly correlated genes for CSE1L:

 

Showing top 20/1919 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CSE1LNELFCD0.80236810010
CSE1LGINS10.80105311011
CSE1LUBE2C0.79806712012
CSE1LAURKA0.79408612012
CSE1LMRPL380.788704303
CSE1LRAD180.779952303
CSE1LALG10.778528404
CSE1LMMS22L0.768986303
CSE1LCDKN30.76403712011
CSE1LZNF7070.763941303
CSE1LPTCD10.762797303
CSE1LDLGAP50.75742511011
CSE1LWDHD10.75489812011
CSE1LNDC10.753873909
CSE1LTPX20.75375112011
CSE1LNOP560.752721303
CSE1LMRGBP0.7490611009
CSE1LCHEK10.74476512012
CSE1LCSTF10.74273112011
CSE1LKIF140.7415211011

For details and further investigation, click here