YTHDF1

 

Full name: YTH N6-methyladenosine RNA binding protein 1 Alias Symbol: FLJ20391
Type: protein-coding gene Cytoband: 20q13.33
Entrez ID: 54915 HGNC ID: HGNC:15867 Ensembl Gene: ENSG00000149658 OMIM ID: 616529
Drug and gene relationship at DGIdb

 

Expression of YTHDF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 YTHDF1 54915 221741_s_at 0.9673 0.0336
GSE20347 YTHDF1 54915 221741_s_at 0.4671 0.0006
GSE23400 YTHDF1 54915 221741_s_at 0.6762 0.0000
GSE26886 YTHDF1 54915 221741_s_at 0.2909 0.2901
GSE29001 YTHDF1 54915 221741_s_at 0.8718 0.0002
GSE38129 YTHDF1 54915 221741_s_at 0.6066 0.0000
GSE45670 YTHDF1 54915 221741_s_at 0.4421 0.0066
GSE53622 YTHDF1 54915 26701 0.7926 0.0000
GSE53624 YTHDF1 54915 37677 0.6649 0.0000
GSE63941 YTHDF1 54915 221741_s_at 0.0377 0.9471
GSE77861 YTHDF1 54915 221741_s_at 0.6842 0.0020
GSE97050 YTHDF1 54915 A_33_P3407103 0.9329 0.0750
SRP007169 YTHDF1 54915 RNAseq 0.6481 0.0486
SRP008496 YTHDF1 54915 RNAseq 0.7454 0.0002
SRP064894 YTHDF1 54915 RNAseq 0.5970 0.0000
SRP133303 YTHDF1 54915 RNAseq 0.7421 0.0000
SRP159526 YTHDF1 54915 RNAseq 0.7843 0.0025
SRP193095 YTHDF1 54915 RNAseq 0.5037 0.0000
SRP219564 YTHDF1 54915 RNAseq 0.7730 0.0127
TCGA YTHDF1 54915 RNAseq 0.0954 0.0392

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by YTHDF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of YTHDF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 YTHDF1 54915 14 2 14
GSE20123 YTHDF1 54915 14 2 14
GSE43470 YTHDF1 54915 11 1 31
GSE46452 YTHDF1 54915 35 0 24
GSE47630 YTHDF1 54915 25 1 14
GSE54993 YTHDF1 54915 0 17 53
GSE54994 YTHDF1 54915 29 0 24
GSE60625 YTHDF1 54915 0 0 11
GSE74703 YTHDF1 54915 10 0 26
GSE74704 YTHDF1 54915 11 0 9
TCGA YTHDF1 54915 44 4 48

Total number of gains: 193; Total number of losses: 27; Total Number of normals: 268.  

 

Somatic mutations of YTHDF1:

 

Generating mutation plots.

 

Highly correlated genes for YTHDF1:

 

Showing top 20/2015 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
YTHDF1MRGBP0.80165510010
YTHDF1CDCA20.772511404
YTHDF1RAE10.76929412012
YTHDF1AURKA0.7519410010
YTHDF1SPNS10.748258404
YTHDF1UBE2C0.74527510010
YTHDF1NOP560.74475303
YTHDF1CCDC860.743835707
YTHDF1SPON20.740119303
YTHDF1CSE1L0.73230711010
YTHDF1TPX20.73172710010
YTHDF1CBLB0.729549606
YTHDF1DOCK60.728103303
YTHDF1APMAP0.72342210010
YTHDF1MCM80.719815606
YTHDF1PYCR20.719777303
YTHDF1NAF10.718352404
YTHDF1NACC10.718094303
YTHDF1CIAO10.717472505
YTHDF1MYBL20.71740810010

For details and further investigation, click here