| Full name: erb-b2 receptor tyrosine kinase 4 | Alias Symbol: ALS19|HER4 | ||
| Type: protein-coding gene | Cytoband: 2q34 | ||
| Entrez ID: 2066 | HGNC ID: HGNC:3432 | Ensembl Gene: ENSG00000178568 | OMIM ID: 600543 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ERBB4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04012 | ErbB signaling pathway | |
| hsa04020 | Calcium signaling pathway | |
| hsa05205 | Proteoglycans in cancer |
Expression of ERBB4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERBB4 | 2066 | 206794_at | -0.0499 | 0.8942 | |
| GSE20347 | ERBB4 | 2066 | 206794_at | -0.0027 | 0.9763 | |
| GSE23400 | ERBB4 | 2066 | 214053_at | -0.0719 | 0.1917 | |
| GSE26886 | ERBB4 | 2066 | 233498_at | 0.0125 | 0.9356 | |
| GSE29001 | ERBB4 | 2066 | 214053_at | 0.1314 | 0.7239 | |
| GSE38129 | ERBB4 | 2066 | 206794_at | -0.0379 | 0.5577 | |
| GSE45670 | ERBB4 | 2066 | 233498_at | -0.1870 | 0.3085 | |
| GSE53622 | ERBB4 | 2066 | 67883 | -1.3148 | 0.0000 | |
| GSE53624 | ERBB4 | 2066 | 67883 | -2.1026 | 0.0000 | |
| GSE63941 | ERBB4 | 2066 | 233498_at | 0.0697 | 0.7910 | |
| GSE77861 | ERBB4 | 2066 | 233498_at | -0.0310 | 0.8370 | |
| SRP133303 | ERBB4 | 2066 | RNAseq | -1.9219 | 0.0440 | |
| TCGA | ERBB4 | 2066 | RNAseq | -2.8272 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ERBB4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ERBB4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERBB4 | 2066 | 1 | 13 | 16 | |
| GSE20123 | ERBB4 | 2066 | 1 | 13 | 16 | |
| GSE43470 | ERBB4 | 2066 | 1 | 6 | 36 | |
| GSE46452 | ERBB4 | 2066 | 0 | 5 | 54 | |
| GSE47630 | ERBB4 | 2066 | 4 | 5 | 31 | |
| GSE54993 | ERBB4 | 2066 | 0 | 3 | 67 | |
| GSE54994 | ERBB4 | 2066 | 9 | 10 | 34 | |
| GSE60625 | ERBB4 | 2066 | 0 | 3 | 8 | |
| GSE74703 | ERBB4 | 2066 | 1 | 5 | 30 | |
| GSE74704 | ERBB4 | 2066 | 1 | 7 | 12 | |
| TCGA | ERBB4 | 2066 | 13 | 30 | 53 |
Total number of gains: 31; Total number of losses: 100; Total Number of normals: 357.
Somatic mutations of ERBB4:
Generating mutation plots.
Highly correlated genes for ERBB4:
Showing top 20/70 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERBB4 | TSPAN8 | 0.725399 | 3 | 0 | 3 |
| ERBB4 | DEFA4 | 0.674728 | 3 | 0 | 3 |
| ERBB4 | CHST9 | 0.643159 | 3 | 0 | 3 |
| ERBB4 | AGR3 | 0.628892 | 4 | 0 | 4 |
| ERBB4 | LGALS9 | 0.62612 | 4 | 0 | 3 |
| ERBB4 | CAPN9 | 0.622844 | 5 | 0 | 5 |
| ERBB4 | SCGB1D2 | 0.620054 | 4 | 0 | 4 |
| ERBB4 | TUBB1 | 0.617542 | 3 | 0 | 3 |
| ERBB4 | MS4A8 | 0.611757 | 4 | 0 | 3 |
| ERBB4 | NKX3-1 | 0.608775 | 3 | 0 | 3 |
| ERBB4 | PRB4 | 0.608152 | 3 | 0 | 3 |
| ERBB4 | ZNF74 | 0.603551 | 3 | 0 | 3 |
| ERBB4 | KIAA1324 | 0.603209 | 3 | 0 | 3 |
| ERBB4 | SLC44A4 | 0.597954 | 4 | 0 | 3 |
| ERBB4 | TFF3 | 0.59788 | 4 | 0 | 3 |
| ERBB4 | HMGCS2 | 0.594323 | 4 | 0 | 3 |
| ERBB4 | KCNV2 | 0.590157 | 4 | 0 | 3 |
| ERBB4 | S1PR2 | 0.585858 | 3 | 0 | 3 |
| ERBB4 | PAX2 | 0.584018 | 4 | 0 | 3 |
| ERBB4 | TAS2R16 | 0.581173 | 3 | 0 | 3 |
For details and further investigation, click here
