| Full name: parathyroid hormone | Alias Symbol: PTH1 | ||
| Type: protein-coding gene | Cytoband: 11p15.3 | ||
| Entrez ID: 5741 | HGNC ID: HGNC:9606 | Ensembl Gene: ENSG00000152266 | OMIM ID: 168450 |
| Drug and gene relationship at DGIdb | |||
Expression of PTH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTH | 5741 | 206977_at | -0.0124 | 0.9646 | |
| GSE20347 | PTH | 5741 | 206977_at | 0.0175 | 0.6785 | |
| GSE23400 | PTH | 5741 | 206977_at | -0.0467 | 0.0066 | |
| GSE26886 | PTH | 5741 | 206977_at | 0.0322 | 0.6977 | |
| GSE29001 | PTH | 5741 | 206977_at | -0.0604 | 0.5008 | |
| GSE38129 | PTH | 5741 | 206977_at | -0.0088 | 0.8420 | |
| GSE45670 | PTH | 5741 | 206977_at | 0.0296 | 0.6451 | |
| GSE53622 | PTH | 5741 | 13550 | -0.0301 | 0.7464 | |
| GSE53624 | PTH | 5741 | 13550 | -0.5048 | 0.0001 | |
| GSE63941 | PTH | 5741 | 206977_at | 0.0342 | 0.7571 | |
| GSE77861 | PTH | 5741 | 206977_at | -0.0251 | 0.7277 | |
| TCGA | PTH | 5741 | RNAseq | -3.8398 | 0.0569 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PTH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTH | 5741 | 0 | 9 | 21 | |
| GSE20123 | PTH | 5741 | 0 | 9 | 21 | |
| GSE43470 | PTH | 5741 | 1 | 5 | 37 | |
| GSE46452 | PTH | 5741 | 7 | 5 | 47 | |
| GSE47630 | PTH | 5741 | 3 | 11 | 26 | |
| GSE54993 | PTH | 5741 | 3 | 1 | 66 | |
| GSE54994 | PTH | 5741 | 4 | 12 | 37 | |
| GSE60625 | PTH | 5741 | 0 | 0 | 11 | |
| GSE74703 | PTH | 5741 | 1 | 3 | 32 | |
| GSE74704 | PTH | 5741 | 0 | 8 | 12 | |
| TCGA | PTH | 5741 | 13 | 31 | 52 |
Total number of gains: 32; Total number of losses: 94; Total Number of normals: 362.
Somatic mutations of PTH:
Generating mutation plots.
Highly correlated genes for PTH:
Showing top 20/248 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTH | ARMC4 | 0.760453 | 3 | 0 | 3 |
| PTH | SLC16A8 | 0.742159 | 3 | 0 | 3 |
| PTH | MYBPH | 0.723597 | 3 | 0 | 3 |
| PTH | DEFA4 | 0.717015 | 3 | 0 | 3 |
| PTH | CYP2D6 | 0.71684 | 3 | 0 | 3 |
| PTH | ZMAT4 | 0.710114 | 3 | 0 | 3 |
| PTH | OR2H2 | 0.704269 | 3 | 0 | 3 |
| PTH | SLC5A5 | 0.703447 | 3 | 0 | 3 |
| PTH | HOXA3 | 0.698083 | 3 | 0 | 3 |
| PTH | LCT | 0.689061 | 4 | 0 | 4 |
| PTH | HUNK | 0.687526 | 3 | 0 | 3 |
| PTH | OVOL3 | 0.685427 | 3 | 0 | 3 |
| PTH | ADAMTS13 | 0.671866 | 3 | 0 | 3 |
| PTH | LINC00563 | 0.66852 | 3 | 0 | 3 |
| PTH | IFNA7 | 0.662012 | 3 | 0 | 3 |
| PTH | SLC28A2 | 0.660219 | 3 | 0 | 3 |
| PTH | TUBB4A | 0.659882 | 3 | 0 | 3 |
| PTH | GNRHR | 0.655278 | 3 | 0 | 3 |
| PTH | CRHR2 | 0.651727 | 3 | 0 | 3 |
| PTH | FEV | 0.65027 | 3 | 0 | 3 |
For details and further investigation, click here
