| Full name: nitric oxide synthase 1 | Alias Symbol: nNOS | ||
| Type: protein-coding gene | Cytoband: 12q24.22 | ||
| Entrez ID: 4842 | HGNC ID: HGNC:7872 | Ensembl Gene: ENSG00000089250 | OMIM ID: 163731 |
| Drug and gene relationship at DGIdb | |||
NOS1 involved pathways:
Expression of NOS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NOS1 | 4842 | 207310_s_at | -0.0079 | 0.9813 | |
| GSE20347 | NOS1 | 4842 | 207310_s_at | -0.0426 | 0.5506 | |
| GSE23400 | NOS1 | 4842 | 207309_at | -0.1502 | 0.0006 | |
| GSE26886 | NOS1 | 4842 | 207310_s_at | 0.0128 | 0.9253 | |
| GSE29001 | NOS1 | 4842 | 207309_at | -0.2521 | 0.1975 | |
| GSE38129 | NOS1 | 4842 | 207310_s_at | -0.1486 | 0.0945 | |
| GSE45670 | NOS1 | 4842 | 207309_at | 0.2007 | 0.0506 | |
| GSE53622 | NOS1 | 4842 | 5361 | 0.0105 | 0.9641 | |
| GSE53624 | NOS1 | 4842 | 5361 | -0.0505 | 0.6664 | |
| GSE63941 | NOS1 | 4842 | 239132_at | 2.0996 | 0.2248 | |
| GSE77861 | NOS1 | 4842 | 207309_at | -0.0511 | 0.5503 | |
| GSE97050 | NOS1 | 4842 | A_33_P3365167 | -0.7508 | 0.2913 | |
| SRP007169 | NOS1 | 4842 | RNAseq | 2.5381 | 0.0005 | |
| SRP064894 | NOS1 | 4842 | RNAseq | -0.2256 | 0.5424 | |
| SRP133303 | NOS1 | 4842 | RNAseq | -0.1895 | 0.2241 | |
| SRP159526 | NOS1 | 4842 | RNAseq | 0.9494 | 0.0593 | |
| SRP193095 | NOS1 | 4842 | RNAseq | 0.9028 | 0.0019 | |
| SRP219564 | NOS1 | 4842 | RNAseq | 1.1423 | 0.0138 | |
| TCGA | NOS1 | 4842 | RNAseq | 0.0231 | 0.9645 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NOS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NOS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NOS1 | 4842 | 4 | 3 | 23 | |
| GSE20123 | NOS1 | 4842 | 3 | 3 | 24 | |
| GSE43470 | NOS1 | 4842 | 2 | 0 | 41 | |
| GSE46452 | NOS1 | 4842 | 9 | 1 | 49 | |
| GSE47630 | NOS1 | 4842 | 9 | 3 | 28 | |
| GSE54993 | NOS1 | 4842 | 0 | 5 | 65 | |
| GSE54994 | NOS1 | 4842 | 6 | 5 | 42 | |
| GSE60625 | NOS1 | 4842 | 0 | 0 | 11 | |
| GSE74703 | NOS1 | 4842 | 2 | 0 | 34 | |
| GSE74704 | NOS1 | 4842 | 2 | 2 | 16 | |
| TCGA | NOS1 | 4842 | 21 | 10 | 65 |
Total number of gains: 58; Total number of losses: 32; Total Number of normals: 398.
Somatic mutations of NOS1:
Generating mutation plots.
Highly correlated genes for NOS1:
Showing top 20/1025 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NOS1 | NAT2 | 0.780736 | 3 | 0 | 3 |
| NOS1 | INO80D | 0.761987 | 4 | 0 | 4 |
| NOS1 | KSR1 | 0.741283 | 4 | 0 | 4 |
| NOS1 | DEFA4 | 0.731178 | 5 | 0 | 5 |
| NOS1 | JAK3 | 0.72599 | 3 | 0 | 3 |
| NOS1 | ART4 | 0.725639 | 4 | 0 | 3 |
| NOS1 | ZFHX2 | 0.723498 | 4 | 0 | 4 |
| NOS1 | LGALS14 | 0.720396 | 3 | 0 | 3 |
| NOS1 | KRT76 | 0.710371 | 4 | 0 | 4 |
| NOS1 | EPHA5 | 0.710095 | 5 | 0 | 4 |
| NOS1 | FUT9 | 0.704974 | 3 | 0 | 3 |
| NOS1 | BCAN | 0.704542 | 8 | 0 | 8 |
| NOS1 | ATP8B3 | 0.702499 | 3 | 0 | 3 |
| NOS1 | NTRK3 | 0.702381 | 5 | 0 | 5 |
| NOS1 | CCL1 | 0.699435 | 5 | 0 | 4 |
| NOS1 | GPLD1 | 0.697987 | 4 | 0 | 4 |
| NOS1 | IFNA21 | 0.695199 | 4 | 0 | 3 |
| NOS1 | OR2S2 | 0.69424 | 4 | 0 | 4 |
| NOS1 | KIR2DS3 | 0.690356 | 6 | 0 | 5 |
| NOS1 | FOLH1 | 0.687632 | 3 | 0 | 3 |
For details and further investigation, click here
