| Full name: secreted frizzled related protein 5 | Alias Symbol: SARP3 | ||
| Type: protein-coding gene | Cytoband: 10q24.2 | ||
| Entrez ID: 6425 | HGNC ID: HGNC:10779 | Ensembl Gene: ENSG00000120057 | OMIM ID: 604158 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SFRP5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of SFRP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SFRP5 | 6425 | 207468_s_at | -0.1759 | 0.5947 | |
| GSE20347 | SFRP5 | 6425 | 207468_s_at | 0.0085 | 0.9088 | |
| GSE23400 | SFRP5 | 6425 | 207468_s_at | -0.0492 | 0.0408 | |
| GSE26886 | SFRP5 | 6425 | 207468_s_at | 0.0051 | 0.9735 | |
| GSE29001 | SFRP5 | 6425 | 207468_s_at | -0.1195 | 0.3157 | |
| GSE38129 | SFRP5 | 6425 | 207468_s_at | -0.0491 | 0.7378 | |
| GSE45670 | SFRP5 | 6425 | 207468_s_at | -0.1902 | 0.0399 | |
| GSE53622 | SFRP5 | 6425 | 93918 | -3.0106 | 0.0000 | |
| GSE53624 | SFRP5 | 6425 | 93918 | -3.7300 | 0.0000 | |
| GSE63941 | SFRP5 | 6425 | 207468_s_at | 0.4066 | 0.0322 | |
| GSE77861 | SFRP5 | 6425 | 207468_s_at | -0.1431 | 0.3069 | |
| TCGA | SFRP5 | 6425 | RNAseq | -1.8634 | 0.0043 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by SFRP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SFRP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SFRP5 | 6425 | 1 | 8 | 21 | |
| GSE20123 | SFRP5 | 6425 | 1 | 7 | 22 | |
| GSE43470 | SFRP5 | 6425 | 0 | 7 | 36 | |
| GSE46452 | SFRP5 | 6425 | 0 | 11 | 48 | |
| GSE47630 | SFRP5 | 6425 | 2 | 14 | 24 | |
| GSE54993 | SFRP5 | 6425 | 8 | 0 | 62 | |
| GSE54994 | SFRP5 | 6425 | 2 | 11 | 40 | |
| GSE60625 | SFRP5 | 6425 | 0 | 0 | 11 | |
| GSE74703 | SFRP5 | 6425 | 0 | 5 | 31 | |
| GSE74704 | SFRP5 | 6425 | 0 | 4 | 16 | |
| TCGA | SFRP5 | 6425 | 5 | 28 | 63 |
Total number of gains: 19; Total number of losses: 95; Total Number of normals: 374.
Somatic mutations of SFRP5:
Generating mutation plots.
Highly correlated genes for SFRP5:
Showing top 20/683 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SFRP5 | ARID5A | 0.848836 | 3 | 0 | 3 |
| SFRP5 | BTBD19 | 0.788502 | 3 | 0 | 3 |
| SFRP5 | CLCA4 | 0.775181 | 3 | 0 | 3 |
| SFRP5 | CACNA1H | 0.774362 | 3 | 0 | 3 |
| SFRP5 | ASTN1 | 0.764347 | 5 | 0 | 5 |
| SFRP5 | SPHKAP | 0.759396 | 4 | 0 | 4 |
| SFRP5 | SLC4A3 | 0.753116 | 3 | 0 | 3 |
| SFRP5 | OTOF | 0.746831 | 3 | 0 | 3 |
| SFRP5 | MAL | 0.741919 | 3 | 0 | 3 |
| SFRP5 | CNKSR2 | 0.738171 | 3 | 0 | 3 |
| SFRP5 | EMP1 | 0.730407 | 3 | 0 | 3 |
| SFRP5 | PRSS27 | 0.728809 | 3 | 0 | 3 |
| SFRP5 | SCEL | 0.728625 | 3 | 0 | 3 |
| SFRP5 | SREBF2 | 0.728017 | 3 | 0 | 3 |
| SFRP5 | ABLIM1 | 0.724159 | 3 | 0 | 3 |
| SFRP5 | LNX1 | 0.719938 | 3 | 0 | 3 |
| SFRP5 | NTNG1 | 0.719628 | 4 | 0 | 3 |
| SFRP5 | KRT4 | 0.718793 | 3 | 0 | 3 |
| SFRP5 | PPL | 0.715455 | 3 | 0 | 3 |
| SFRP5 | TMPRSS11E | 0.713916 | 3 | 0 | 3 |
For details and further investigation, click here
