| Full name: coagulation factor XII | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q35.3 | ||
| Entrez ID: 2161 | HGNC ID: HGNC:3530 | Ensembl Gene: ENSG00000131187 | OMIM ID: 610619 |
| Drug and gene relationship at DGIdb | |||
F12 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of F12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | F12 | 2161 | 205774_at | 0.1821 | 0.6967 | |
| GSE20347 | F12 | 2161 | 205774_at | -0.2863 | 0.1451 | |
| GSE23400 | F12 | 2161 | 205774_at | -0.0426 | 0.7267 | |
| GSE26886 | F12 | 2161 | 205774_at | 0.6124 | 0.0005 | |
| GSE29001 | F12 | 2161 | 205774_at | -0.4231 | 0.2345 | |
| GSE38129 | F12 | 2161 | 205774_at | 0.4811 | 0.0896 | |
| GSE45670 | F12 | 2161 | 205774_at | 0.4594 | 0.0138 | |
| GSE53622 | F12 | 2161 | 22700 | -0.1465 | 0.5414 | |
| GSE53624 | F12 | 2161 | 22700 | -0.0144 | 0.9201 | |
| GSE63941 | F12 | 2161 | 205774_at | 2.3428 | 0.0012 | |
| GSE77861 | F12 | 2161 | 205774_at | -0.3132 | 0.1630 | |
| GSE97050 | F12 | 2161 | A_33_P3233871 | 0.3245 | 0.2082 | |
| SRP007169 | F12 | 2161 | RNAseq | -1.9414 | 0.0000 | |
| SRP008496 | F12 | 2161 | RNAseq | -1.4468 | 0.0001 | |
| SRP064894 | F12 | 2161 | RNAseq | 0.1937 | 0.6486 | |
| SRP133303 | F12 | 2161 | RNAseq | -0.2857 | 0.1571 | |
| SRP159526 | F12 | 2161 | RNAseq | -0.5482 | 0.1888 | |
| SRP219564 | F12 | 2161 | RNAseq | 0.3497 | 0.6978 | |
| TCGA | F12 | 2161 | RNAseq | 1.4350 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by F12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of F12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | F12 | 2161 | 2 | 13 | 15 | |
| GSE20123 | F12 | 2161 | 2 | 13 | 15 | |
| GSE43470 | F12 | 2161 | 1 | 11 | 31 | |
| GSE46452 | F12 | 2161 | 0 | 27 | 32 | |
| GSE47630 | F12 | 2161 | 1 | 20 | 19 | |
| GSE54993 | F12 | 2161 | 10 | 2 | 58 | |
| GSE54994 | F12 | 2161 | 2 | 17 | 34 | |
| GSE60625 | F12 | 2161 | 1 | 0 | 10 | |
| GSE74703 | F12 | 2161 | 1 | 7 | 28 | |
| GSE74704 | F12 | 2161 | 1 | 6 | 13 | |
| TCGA | F12 | 2161 | 8 | 34 | 54 |
Total number of gains: 29; Total number of losses: 150; Total Number of normals: 309.
Somatic mutations of F12:
Generating mutation plots.
Highly correlated genes for F12:
Showing top 20/461 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| F12 | DENND1B | 0.729934 | 4 | 0 | 4 |
| F12 | MRPL32 | 0.716356 | 3 | 0 | 3 |
| F12 | TCEANC2 | 0.714987 | 3 | 0 | 3 |
| F12 | ERCC8 | 0.712035 | 3 | 0 | 3 |
| F12 | SYN3 | 0.699092 | 3 | 0 | 3 |
| F12 | MRPS31 | 0.691869 | 3 | 0 | 3 |
| F12 | PRELID2 | 0.686107 | 3 | 0 | 3 |
| F12 | NHSL1 | 0.683593 | 3 | 0 | 3 |
| F12 | GGN | 0.682399 | 3 | 0 | 3 |
| F12 | HES4 | 0.678897 | 3 | 0 | 3 |
| F12 | DDX19A | 0.677 | 3 | 0 | 3 |
| F12 | MEA1 | 0.676182 | 3 | 0 | 3 |
| F12 | TMEM65 | 0.672458 | 4 | 0 | 4 |
| F12 | TTC26 | 0.672405 | 3 | 0 | 3 |
| F12 | PNO1 | 0.666907 | 3 | 0 | 3 |
| F12 | CDK5R1 | 0.666897 | 5 | 0 | 4 |
| F12 | C12orf45 | 0.664014 | 4 | 0 | 3 |
| F12 | RPS19 | 0.661912 | 3 | 0 | 3 |
| F12 | GAS2L1 | 0.661493 | 4 | 0 | 3 |
| F12 | TSC22D4 | 0.661263 | 4 | 0 | 4 |
For details and further investigation, click here
