| Full name: DExD-box helicase 52 | Alias Symbol: ROK1 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 11056 | HGNC ID: HGNC:20038 | Ensembl Gene: ENSG00000278053 | OMIM ID: 612500 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDX52:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX52 | 11056 | 213637_at | 0.0868 | 0.8855 | |
| GSE20347 | DDX52 | 11056 | 212834_at | -0.1902 | 0.1907 | |
| GSE23400 | DDX52 | 11056 | 210320_s_at | 0.0207 | 0.6772 | |
| GSE26886 | DDX52 | 11056 | 210320_s_at | -0.7094 | 0.0073 | |
| GSE29001 | DDX52 | 11056 | 210320_s_at | -0.4274 | 0.0157 | |
| GSE38129 | DDX52 | 11056 | 213637_at | 0.1941 | 0.1554 | |
| GSE45670 | DDX52 | 11056 | 213637_at | 0.0861 | 0.5940 | |
| GSE53622 | DDX52 | 11056 | 41651 | 0.1681 | 0.0100 | |
| GSE53624 | DDX52 | 11056 | 41651 | 0.0999 | 0.1312 | |
| GSE63941 | DDX52 | 11056 | 210320_s_at | 0.0530 | 0.9081 | |
| GSE77861 | DDX52 | 11056 | 210320_s_at | -0.0637 | 0.7699 | |
| GSE97050 | DDX52 | 11056 | A_33_P3372869 | 0.1770 | 0.5480 | |
| SRP007169 | DDX52 | 11056 | RNAseq | -0.2742 | 0.4150 | |
| SRP008496 | DDX52 | 11056 | RNAseq | -0.2819 | 0.1522 | |
| SRP064894 | DDX52 | 11056 | RNAseq | -0.1615 | 0.3411 | |
| SRP133303 | DDX52 | 11056 | RNAseq | 0.1238 | 0.2414 | |
| SRP159526 | DDX52 | 11056 | RNAseq | -0.1438 | 0.5065 | |
| SRP193095 | DDX52 | 11056 | RNAseq | -0.1996 | 0.0160 | |
| SRP219564 | DDX52 | 11056 | RNAseq | -0.2731 | 0.3583 | |
| TCGA | DDX52 | 11056 | RNAseq | 0.0759 | 0.1445 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DDX52 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX52:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX52 | 11056 | 6 | 1 | 23 | |
| GSE20123 | DDX52 | 11056 | 6 | 1 | 23 | |
| GSE43470 | DDX52 | 11056 | 1 | 2 | 40 | |
| GSE46452 | DDX52 | 11056 | 34 | 0 | 25 | |
| GSE47630 | DDX52 | 11056 | 8 | 1 | 31 | |
| GSE54993 | DDX52 | 11056 | 3 | 3 | 64 | |
| GSE54994 | DDX52 | 11056 | 9 | 4 | 40 | |
| GSE60625 | DDX52 | 11056 | 4 | 0 | 7 | |
| GSE74703 | DDX52 | 11056 | 1 | 1 | 34 | |
| GSE74704 | DDX52 | 11056 | 3 | 1 | 16 | |
| TCGA | DDX52 | 11056 | 19 | 9 | 68 |
Total number of gains: 94; Total number of losses: 23; Total Number of normals: 371.
Somatic mutations of DDX52:
Generating mutation plots.
Highly correlated genes for DDX52:
Showing top 20/374 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX52 | DENND1B | 0.824353 | 3 | 0 | 3 |
| DDX52 | EPG5 | 0.782588 | 3 | 0 | 3 |
| DDX52 | TNKS2 | 0.743814 | 3 | 0 | 3 |
| DDX52 | CCNYL1 | 0.742045 | 3 | 0 | 3 |
| DDX52 | COMMD8 | 0.738699 | 3 | 0 | 3 |
| DDX52 | MTA3 | 0.738083 | 3 | 0 | 3 |
| DDX52 | TMCC3 | 0.72767 | 3 | 0 | 3 |
| DDX52 | AK3 | 0.724715 | 3 | 0 | 3 |
| DDX52 | RAB1A | 0.722642 | 3 | 0 | 3 |
| DDX52 | MRPL35 | 0.719331 | 3 | 0 | 3 |
| DDX52 | ZNF710 | 0.715946 | 4 | 0 | 3 |
| DDX52 | QRICH1 | 0.711347 | 3 | 0 | 3 |
| DDX52 | PLEKHG1 | 0.710078 | 3 | 0 | 3 |
| DDX52 | SLC12A6 | 0.7012 | 4 | 0 | 4 |
| DDX52 | GTF3C4 | 0.69702 | 3 | 0 | 3 |
| DDX52 | ZNF92 | 0.696325 | 3 | 0 | 3 |
| DDX52 | CLN8 | 0.69371 | 3 | 0 | 3 |
| DDX52 | ANO10 | 0.6931 | 3 | 0 | 3 |
| DDX52 | SLC22A23 | 0.691004 | 3 | 0 | 3 |
| DDX52 | RAB5A | 0.690766 | 4 | 0 | 4 |
For details and further investigation, click here
