| Full name: DEP domain containing MTOR interacting protein | Alias Symbol: DEP.6|FLJ12428 | ||
| Type: protein-coding gene | Cytoband: 8q24.12 | ||
| Entrez ID: 64798 | HGNC ID: HGNC:22953 | Ensembl Gene: ENSG00000155792 | OMIM ID: 612974 |
| Related drugs: AZD-8055, INK-128, OSI-027... [more] | |||
DEPTOR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway |
Expression of DEPTOR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEPTOR | 64798 | 218858_at | -1.6793 | 0.0300 | |
| GSE20347 | DEPTOR | 64798 | 218858_at | -1.5320 | 0.0010 | |
| GSE23400 | DEPTOR | 64798 | 218858_at | -0.5762 | 0.0000 | |
| GSE26886 | DEPTOR | 64798 | 218858_at | -1.4330 | 0.0012 | |
| GSE29001 | DEPTOR | 64798 | 218858_at | -1.6455 | 0.0000 | |
| GSE38129 | DEPTOR | 64798 | 218858_at | -1.6328 | 0.0000 | |
| GSE45670 | DEPTOR | 64798 | 218858_at | -1.8889 | 0.0003 | |
| GSE63941 | DEPTOR | 64798 | 218858_at | -0.9711 | 0.3596 | |
| GSE77861 | DEPTOR | 64798 | 218858_at | -1.5126 | 0.0002 | |
| GSE97050 | DEPTOR | 64798 | A_23_P60166 | -0.5712 | 0.1823 | |
| SRP007169 | DEPTOR | 64798 | RNAseq | -2.7516 | 0.0000 | |
| SRP064894 | DEPTOR | 64798 | RNAseq | -1.4943 | 0.0000 | |
| SRP133303 | DEPTOR | 64798 | RNAseq | -1.7158 | 0.0000 | |
| SRP159526 | DEPTOR | 64798 | RNAseq | -1.5053 | 0.0000 | |
| SRP193095 | DEPTOR | 64798 | RNAseq | -1.4219 | 0.0002 | |
| SRP219564 | DEPTOR | 64798 | RNAseq | -1.5120 | 0.0231 |
Upregulated datasets: 0; Downregulated datasets: 13.
Copy number change of DEPTOR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEPTOR | 64798 | 19 | 1 | 10 | |
| GSE20123 | DEPTOR | 64798 | 20 | 1 | 9 | |
| GSE43470 | DEPTOR | 64798 | 23 | 0 | 20 | |
| GSE46452 | DEPTOR | 64798 | 27 | 0 | 32 | |
| GSE47630 | DEPTOR | 64798 | 24 | 0 | 16 | |
| GSE54993 | DEPTOR | 64798 | 0 | 20 | 50 | |
| GSE54994 | DEPTOR | 64798 | 37 | 0 | 16 | |
| GSE60625 | DEPTOR | 64798 | 0 | 4 | 7 | |
| GSE74703 | DEPTOR | 64798 | 19 | 0 | 17 | |
| GSE74704 | DEPTOR | 64798 | 13 | 1 | 6 | |
| TCGA | DEPTOR | 64798 | 67 | 2 | 27 |
Total number of gains: 249; Total number of losses: 29; Total Number of normals: 210.
Somatic mutations of DEPTOR:
Generating mutation plots.
Highly correlated genes for DEPTOR:
Showing top 20/681 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEPTOR | SH3BGRL2 | 0.807462 | 4 | 0 | 4 |
| DEPTOR | SNORA68 | 0.795503 | 4 | 0 | 4 |
| DEPTOR | GPD1L | 0.766269 | 8 | 0 | 8 |
| DEPTOR | BBS2 | 0.761115 | 3 | 0 | 3 |
| DEPTOR | C5orf66-AS1 | 0.761068 | 4 | 0 | 4 |
| DEPTOR | CGNL1 | 0.755304 | 4 | 0 | 4 |
| DEPTOR | FAM3D | 0.753966 | 4 | 0 | 4 |
| DEPTOR | CTTNBP2 | 0.751819 | 5 | 0 | 5 |
| DEPTOR | MPP7 | 0.749599 | 4 | 0 | 4 |
| DEPTOR | EIF4E3 | 0.746838 | 4 | 0 | 4 |
| DEPTOR | SMDT1 | 0.744013 | 4 | 0 | 3 |
| DEPTOR | ZNF662 | 0.742541 | 4 | 0 | 4 |
| DEPTOR | PAQR8 | 0.734123 | 4 | 0 | 4 |
| DEPTOR | KLB | 0.734086 | 4 | 0 | 4 |
| DEPTOR | METTL7A | 0.733121 | 7 | 0 | 7 |
| DEPTOR | SFTA2 | 0.731635 | 5 | 0 | 4 |
| DEPTOR | VSIG2 | 0.717646 | 4 | 0 | 4 |
| DEPTOR | SETDB2 | 0.713847 | 3 | 0 | 3 |
| DEPTOR | KIAA1211L | 0.711847 | 4 | 0 | 3 |
| DEPTOR | HCG22 | 0.710402 | 4 | 0 | 4 |
For details and further investigation, click here
