| Full name: centromere protein H | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q13.2 | ||
| Entrez ID: 64946 | HGNC ID: HGNC:17268 | Ensembl Gene: ENSG00000153044 | OMIM ID: 605607 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CENPH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CENPH | 64946 | 231772_x_at | 0.4965 | 0.4516 | |
| GSE26886 | CENPH | 64946 | 231772_x_at | 0.8043 | 0.0025 | |
| GSE45670 | CENPH | 64946 | 231772_x_at | 0.5127 | 0.0232 | |
| GSE53622 | CENPH | 64946 | 896 | 1.0233 | 0.0000 | |
| GSE53624 | CENPH | 64946 | 896 | 1.1706 | 0.0000 | |
| GSE63941 | CENPH | 64946 | 231772_x_at | 2.9609 | 0.0000 | |
| GSE77861 | CENPH | 64946 | 231772_x_at | 0.3410 | 0.2508 | |
| GSE97050 | CENPH | 64946 | A_23_P110802 | 0.4825 | 0.2870 | |
| SRP007169 | CENPH | 64946 | RNAseq | 1.2698 | 0.0212 | |
| SRP008496 | CENPH | 64946 | RNAseq | 1.1831 | 0.0180 | |
| SRP064894 | CENPH | 64946 | RNAseq | 0.9600 | 0.0001 | |
| SRP133303 | CENPH | 64946 | RNAseq | 1.0231 | 0.0005 | |
| SRP159526 | CENPH | 64946 | RNAseq | 1.4930 | 0.0002 | |
| SRP193095 | CENPH | 64946 | RNAseq | 0.6114 | 0.0007 | |
| SRP219564 | CENPH | 64946 | RNAseq | 0.5853 | 0.2628 | |
| TCGA | CENPH | 64946 | RNAseq | 0.9197 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by CENPH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CENPH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CENPH | 64946 | 1 | 13 | 16 | |
| GSE20123 | CENPH | 64946 | 1 | 13 | 16 | |
| GSE43470 | CENPH | 64946 | 1 | 12 | 30 | |
| GSE46452 | CENPH | 64946 | 0 | 28 | 31 | |
| GSE47630 | CENPH | 64946 | 2 | 17 | 21 | |
| GSE54993 | CENPH | 64946 | 8 | 1 | 61 | |
| GSE54994 | CENPH | 64946 | 1 | 21 | 31 | |
| GSE60625 | CENPH | 64946 | 0 | 0 | 11 | |
| GSE74703 | CENPH | 64946 | 1 | 9 | 26 | |
| GSE74704 | CENPH | 64946 | 1 | 6 | 13 | |
| TCGA | CENPH | 64946 | 4 | 51 | 41 |
Total number of gains: 20; Total number of losses: 171; Total Number of normals: 297.
Somatic mutations of CENPH:
Generating mutation plots.
Highly correlated genes for CENPH:
Showing top 20/1401 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CENPH | MMS22L | 0.800253 | 3 | 0 | 3 |
| CENPH | DKC1 | 0.760962 | 3 | 0 | 3 |
| CENPH | SLC25A24 | 0.758641 | 3 | 0 | 3 |
| CENPH | DHFR | 0.753974 | 5 | 0 | 5 |
| CENPH | UCK2 | 0.74355 | 3 | 0 | 3 |
| CENPH | POPDC3 | 0.731168 | 4 | 0 | 4 |
| CENPH | DOC2B | 0.727274 | 3 | 0 | 3 |
| CENPH | ADSL | 0.721497 | 5 | 0 | 5 |
| CENPH | INTS7 | 0.720491 | 4 | 0 | 4 |
| CENPH | SPAG5 | 0.71949 | 7 | 0 | 7 |
| CENPH | TTK | 0.718222 | 7 | 0 | 6 |
| CENPH | DEPDC1B | 0.717698 | 7 | 0 | 7 |
| CENPH | GINS1 | 0.714558 | 8 | 0 | 8 |
| CENPH | CDK1 | 0.713956 | 7 | 0 | 7 |
| CENPH | HMGB2 | 0.710911 | 4 | 0 | 4 |
| CENPH | PCNA | 0.710396 | 8 | 0 | 8 |
| CENPH | RFC2 | 0.709351 | 8 | 0 | 7 |
| CENPH | CCNB2 | 0.709135 | 7 | 0 | 6 |
| CENPH | DNA2 | 0.708131 | 7 | 0 | 6 |
| CENPH | MKNK1 | 0.707482 | 3 | 0 | 3 |
For details and further investigation, click here
