| Full name: lysine demethylase 4A | Alias Symbol: KIAA0677|JHDM3A|TDRD14A | ||
| Type: protein-coding gene | Cytoband: 1p34.2-p34.1 | ||
| Entrez ID: 9682 | HGNC ID: HGNC:22978 | Ensembl Gene: ENSG00000066135 | OMIM ID: 609764 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KDM4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KDM4A | 9682 | 203204_s_at | 0.2197 | 0.6098 | |
| GSE20347 | KDM4A | 9682 | 203205_at | 0.2835 | 0.0105 | |
| GSE23400 | KDM4A | 9682 | 203205_at | -0.0024 | 0.9646 | |
| GSE26886 | KDM4A | 9682 | 203204_s_at | -0.3171 | 0.0979 | |
| GSE29001 | KDM4A | 9682 | 203205_at | 0.1522 | 0.5382 | |
| GSE38129 | KDM4A | 9682 | 203205_at | 0.2784 | 0.0013 | |
| GSE45670 | KDM4A | 9682 | 203205_at | 0.2915 | 0.0032 | |
| GSE63941 | KDM4A | 9682 | 203204_s_at | 0.1679 | 0.6695 | |
| GSE77861 | KDM4A | 9682 | 203205_at | 0.0925 | 0.5116 | |
| GSE97050 | KDM4A | 9682 | A_33_P3420655 | -0.0903 | 0.6436 | |
| SRP007169 | KDM4A | 9682 | RNAseq | 0.6703 | 0.0694 | |
| SRP008496 | KDM4A | 9682 | RNAseq | 0.8235 | 0.0018 | |
| SRP064894 | KDM4A | 9682 | RNAseq | 0.3810 | 0.0258 | |
| SRP133303 | KDM4A | 9682 | RNAseq | 0.2114 | 0.0824 | |
| SRP159526 | KDM4A | 9682 | RNAseq | 0.8024 | 0.0405 | |
| SRP193095 | KDM4A | 9682 | RNAseq | 0.1808 | 0.1609 | |
| SRP219564 | KDM4A | 9682 | RNAseq | 0.3549 | 0.3004 | |
| TCGA | KDM4A | 9682 | RNAseq | 0.0804 | 0.1040 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KDM4A expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KDM4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KDM4A | 9682 | 4 | 3 | 23 | |
| GSE20123 | KDM4A | 9682 | 4 | 2 | 24 | |
| GSE43470 | KDM4A | 9682 | 7 | 2 | 34 | |
| GSE46452 | KDM4A | 9682 | 3 | 1 | 55 | |
| GSE47630 | KDM4A | 9682 | 9 | 3 | 28 | |
| GSE54993 | KDM4A | 9682 | 0 | 2 | 68 | |
| GSE54994 | KDM4A | 9682 | 13 | 2 | 38 | |
| GSE60625 | KDM4A | 9682 | 0 | 0 | 11 | |
| GSE74703 | KDM4A | 9682 | 6 | 1 | 29 | |
| GSE74704 | KDM4A | 9682 | 2 | 0 | 18 | |
| TCGA | KDM4A | 9682 | 15 | 16 | 65 |
Total number of gains: 63; Total number of losses: 32; Total Number of normals: 393.
Somatic mutations of KDM4A:
Generating mutation plots.
Highly correlated genes for KDM4A:
Showing top 20/404 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KDM4A | ZNF740 | 0.811678 | 3 | 0 | 3 |
| KDM4A | DHPS | 0.802517 | 3 | 0 | 3 |
| KDM4A | ZNF641 | 0.795376 | 3 | 0 | 3 |
| KDM4A | RBM4B | 0.791499 | 4 | 0 | 4 |
| KDM4A | SETX | 0.776914 | 3 | 0 | 3 |
| KDM4A | PELI2 | 0.769912 | 3 | 0 | 3 |
| KDM4A | CSNK2B | 0.769094 | 3 | 0 | 3 |
| KDM4A | KLHDC3 | 0.757364 | 4 | 0 | 4 |
| KDM4A | CRTC2 | 0.752337 | 3 | 0 | 3 |
| KDM4A | POLR2J | 0.751222 | 3 | 0 | 3 |
| KDM4A | DGKD | 0.740823 | 4 | 0 | 4 |
| KDM4A | SMARCC2 | 0.737494 | 3 | 0 | 3 |
| KDM4A | COPS7A | 0.73526 | 4 | 0 | 4 |
| KDM4A | SLC9A8 | 0.731068 | 3 | 0 | 3 |
| KDM4A | FOXP4 | 0.730443 | 4 | 0 | 4 |
| KDM4A | MRM1 | 0.721593 | 3 | 0 | 3 |
| KDM4A | ARF5 | 0.719403 | 3 | 0 | 3 |
| KDM4A | PPP5C | 0.717042 | 5 | 0 | 5 |
| KDM4A | NFXL1 | 0.715777 | 3 | 0 | 3 |
| KDM4A | SLC25A1 | 0.715561 | 3 | 0 | 3 |
For details and further investigation, click here
