| Full name: dehydrogenase/reductase 3 | Alias Symbol: retSDR1|Rsdr1|SDR1|RDH17|SDR16C1 | ||
| Type: protein-coding gene | Cytoband: 1p36.21 | ||
| Entrez ID: 9249 | HGNC ID: HGNC:17693 | Ensembl Gene: ENSG00000162496 | OMIM ID: 612830 |
| Drug and gene relationship at DGIdb | |||
Expression of DHRS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHRS3 | 9249 | 202481_at | -0.3625 | 0.6483 | |
| GSE20347 | DHRS3 | 9249 | 202481_at | -0.8135 | 0.0114 | |
| GSE23400 | DHRS3 | 9249 | 202481_at | -0.4180 | 0.0001 | |
| GSE26886 | DHRS3 | 9249 | 202481_at | -0.7451 | 0.0507 | |
| GSE29001 | DHRS3 | 9249 | 202481_at | -0.6640 | 0.1768 | |
| GSE38129 | DHRS3 | 9249 | 202481_at | -0.6322 | 0.0137 | |
| GSE45670 | DHRS3 | 9249 | 202481_at | -0.3491 | 0.1869 | |
| GSE53622 | DHRS3 | 9249 | 43738 | -0.7275 | 0.0000 | |
| GSE53624 | DHRS3 | 9249 | 43738 | -0.8652 | 0.0000 | |
| GSE63941 | DHRS3 | 9249 | 202481_at | -1.7504 | 0.0444 | |
| GSE77861 | DHRS3 | 9249 | 202481_at | -0.9020 | 0.0037 | |
| GSE97050 | DHRS3 | 9249 | A_23_P33759 | 0.0096 | 0.9850 | |
| SRP007169 | DHRS3 | 9249 | RNAseq | -1.8865 | 0.0003 | |
| SRP008496 | DHRS3 | 9249 | RNAseq | -1.4267 | 0.0002 | |
| SRP064894 | DHRS3 | 9249 | RNAseq | 0.1091 | 0.7592 | |
| SRP133303 | DHRS3 | 9249 | RNAseq | -0.6646 | 0.0284 | |
| SRP159526 | DHRS3 | 9249 | RNAseq | 0.0892 | 0.8555 | |
| SRP193095 | DHRS3 | 9249 | RNAseq | -0.7802 | 0.0000 | |
| SRP219564 | DHRS3 | 9249 | RNAseq | -0.4867 | 0.3344 | |
| TCGA | DHRS3 | 9249 | RNAseq | -0.1419 | 0.1354 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by DHRS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHRS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHRS3 | 9249 | 0 | 5 | 25 | |
| GSE20123 | DHRS3 | 9249 | 0 | 4 | 26 | |
| GSE43470 | DHRS3 | 9249 | 3 | 6 | 34 | |
| GSE46452 | DHRS3 | 9249 | 7 | 1 | 51 | |
| GSE47630 | DHRS3 | 9249 | 8 | 4 | 28 | |
| GSE54993 | DHRS3 | 9249 | 3 | 1 | 66 | |
| GSE54994 | DHRS3 | 9249 | 11 | 4 | 38 | |
| GSE60625 | DHRS3 | 9249 | 0 | 0 | 11 | |
| GSE74703 | DHRS3 | 9249 | 2 | 4 | 30 | |
| GSE74704 | DHRS3 | 9249 | 0 | 0 | 20 | |
| TCGA | DHRS3 | 9249 | 11 | 21 | 64 |
Total number of gains: 45; Total number of losses: 50; Total Number of normals: 393.
Somatic mutations of DHRS3:
Generating mutation plots.
Highly correlated genes for DHRS3:
Showing top 20/733 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHRS3 | NUB1 | 0.752965 | 3 | 0 | 3 |
| DHRS3 | FITM2 | 0.70509 | 3 | 0 | 3 |
| DHRS3 | ZRANB1 | 0.703588 | 3 | 0 | 3 |
| DHRS3 | ITPRIPL2 | 0.703045 | 4 | 0 | 4 |
| DHRS3 | GNL3 | 0.702865 | 5 | 0 | 5 |
| DHRS3 | CETN2 | 0.70066 | 3 | 0 | 3 |
| DHRS3 | CYP4X1 | 0.697912 | 7 | 0 | 7 |
| DHRS3 | NDUFS3 | 0.696663 | 3 | 0 | 3 |
| DHRS3 | NAA30 | 0.693418 | 3 | 0 | 3 |
| DHRS3 | EIF2B1 | 0.68683 | 4 | 0 | 3 |
| DHRS3 | TLE4 | 0.685209 | 3 | 0 | 3 |
| DHRS3 | TCHP | 0.679524 | 3 | 0 | 3 |
| DHRS3 | TRNAU1AP | 0.67686 | 4 | 0 | 4 |
| DHRS3 | JAK1 | 0.674834 | 4 | 0 | 4 |
| DHRS3 | STUB1 | 0.6721 | 3 | 0 | 3 |
| DHRS3 | ZBTB1 | 0.67067 | 3 | 0 | 3 |
| DHRS3 | NHS | 0.67042 | 3 | 0 | 3 |
| DHRS3 | AIDA | 0.668347 | 3 | 0 | 3 |
| DHRS3 | SMURF1 | 0.665977 | 3 | 0 | 3 |
| DHRS3 | PACRGL | 0.665403 | 4 | 0 | 3 |
For details and further investigation, click here
