| Full name: TLE family member 4, transcriptional corepressor | Alias Symbol: E(spl)|ESG|GRG4 | ||
| Type: protein-coding gene | Cytoband: 9q21.31 | ||
| Entrez ID: 7091 | HGNC ID: HGNC:11840 | Ensembl Gene: ENSG00000106829 | OMIM ID: 605132 |
| Drug and gene relationship at DGIdb | |||
Expression of TLE4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLE4 | 7091 | 204872_at | -0.0501 | 0.9264 | |
| GSE20347 | TLE4 | 7091 | 204872_at | -0.3772 | 0.1069 | |
| GSE23400 | TLE4 | 7091 | 204872_at | -0.2774 | 0.0163 | |
| GSE26886 | TLE4 | 7091 | 204872_at | -0.4105 | 0.0990 | |
| GSE29001 | TLE4 | 7091 | 204872_at | -0.3327 | 0.5364 | |
| GSE38129 | TLE4 | 7091 | 204872_at | -0.3224 | 0.0645 | |
| GSE45670 | TLE4 | 7091 | 204872_at | -0.0799 | 0.5747 | |
| GSE53622 | TLE4 | 7091 | 90548 | -0.2279 | 0.0061 | |
| GSE53624 | TLE4 | 7091 | 90548 | -0.2128 | 0.0197 | |
| GSE63941 | TLE4 | 7091 | 204872_at | -1.5953 | 0.0595 | |
| GSE77861 | TLE4 | 7091 | 204872_at | -0.0638 | 0.8718 | |
| GSE97050 | TLE4 | 7091 | A_33_P3302681 | 0.2291 | 0.5695 | |
| SRP007169 | TLE4 | 7091 | RNAseq | 0.4739 | 0.2953 | |
| SRP008496 | TLE4 | 7091 | RNAseq | 0.6941 | 0.0090 | |
| SRP064894 | TLE4 | 7091 | RNAseq | -0.1469 | 0.4729 | |
| SRP133303 | TLE4 | 7091 | RNAseq | -0.3897 | 0.0966 | |
| SRP159526 | TLE4 | 7091 | RNAseq | -0.3656 | 0.1246 | |
| SRP193095 | TLE4 | 7091 | RNAseq | -0.3825 | 0.0036 | |
| SRP219564 | TLE4 | 7091 | RNAseq | -0.2057 | 0.4850 | |
| TCGA | TLE4 | 7091 | RNAseq | -0.0684 | 0.4162 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TLE4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLE4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLE4 | 7091 | 5 | 10 | 15 | |
| GSE20123 | TLE4 | 7091 | 5 | 10 | 15 | |
| GSE43470 | TLE4 | 7091 | 6 | 5 | 32 | |
| GSE46452 | TLE4 | 7091 | 6 | 14 | 39 | |
| GSE47630 | TLE4 | 7091 | 1 | 18 | 21 | |
| GSE54993 | TLE4 | 7091 | 4 | 2 | 64 | |
| GSE54994 | TLE4 | 7091 | 4 | 12 | 37 | |
| GSE60625 | TLE4 | 7091 | 0 | 0 | 11 | |
| GSE74703 | TLE4 | 7091 | 5 | 4 | 27 | |
| GSE74704 | TLE4 | 7091 | 3 | 7 | 10 | |
| TCGA | TLE4 | 7091 | 19 | 28 | 49 |
Total number of gains: 58; Total number of losses: 110; Total Number of normals: 320.
Somatic mutations of TLE4:
Generating mutation plots.
Highly correlated genes for TLE4:
Showing top 20/160 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLE4 | ARF6 | 0.792244 | 3 | 0 | 3 |
| TLE4 | COG1 | 0.786484 | 3 | 0 | 3 |
| TLE4 | PPCS | 0.780258 | 3 | 0 | 3 |
| TLE4 | RBM33 | 0.773765 | 3 | 0 | 3 |
| TLE4 | C1orf122 | 0.753335 | 3 | 0 | 3 |
| TLE4 | SRRM1 | 0.750729 | 3 | 0 | 3 |
| TLE4 | SPATA5L1 | 0.750002 | 3 | 0 | 3 |
| TLE4 | PPP2R5E | 0.748517 | 3 | 0 | 3 |
| TLE4 | SH2D4A | 0.730479 | 3 | 0 | 3 |
| TLE4 | SLC37A3 | 0.727495 | 3 | 0 | 3 |
| TLE4 | ZNF578 | 0.721265 | 3 | 0 | 3 |
| TLE4 | TRAPPC6B | 0.71221 | 3 | 0 | 3 |
| TLE4 | EXOC4 | 0.705721 | 4 | 0 | 3 |
| TLE4 | STX6 | 0.705584 | 3 | 0 | 3 |
| TLE4 | CAPZB | 0.704922 | 3 | 0 | 3 |
| TLE4 | MAP4K5 | 0.698744 | 3 | 0 | 3 |
| TLE4 | HADHB | 0.68624 | 3 | 0 | 3 |
| TLE4 | DHRS3 | 0.685209 | 3 | 0 | 3 |
| TLE4 | MKKS | 0.676882 | 3 | 0 | 3 |
| TLE4 | USP8 | 0.674526 | 3 | 0 | 3 |
For details and further investigation, click here
