| Full name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease | Alias Symbol: dis3p|RRP44|EXOSC11 | ||
| Type: protein-coding gene | Cytoband: 13q21.33 | ||
| Entrez ID: 22894 | HGNC ID: HGNC:20604 | Ensembl Gene: ENSG00000083520 | OMIM ID: 607533 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DIS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DIS3 | 22894 | 222607_s_at | 0.5676 | 0.5204 | |
| GSE20347 | DIS3 | 22894 | 218362_s_at | 0.1789 | 0.1398 | |
| GSE23400 | DIS3 | 22894 | 218362_s_at | 0.1462 | 0.0073 | |
| GSE26886 | DIS3 | 22894 | 222607_s_at | 0.4868 | 0.1295 | |
| GSE29001 | DIS3 | 22894 | 218362_s_at | 0.3441 | 0.3158 | |
| GSE38129 | DIS3 | 22894 | 218362_s_at | -0.0642 | 0.7333 | |
| GSE45670 | DIS3 | 22894 | 222607_s_at | 0.2536 | 0.2425 | |
| GSE53622 | DIS3 | 22894 | 39771 | 0.2776 | 0.0033 | |
| GSE53624 | DIS3 | 22894 | 24468 | -0.0967 | 0.3059 | |
| GSE63941 | DIS3 | 22894 | 222607_s_at | -0.3621 | 0.3263 | |
| GSE77861 | DIS3 | 22894 | 222607_s_at | -0.1916 | 0.4739 | |
| GSE97050 | DIS3 | 22894 | A_24_P395317 | -0.1956 | 0.4968 | |
| SRP007169 | DIS3 | 22894 | RNAseq | -0.4822 | 0.1820 | |
| SRP008496 | DIS3 | 22894 | RNAseq | -0.3602 | 0.2102 | |
| SRP064894 | DIS3 | 22894 | RNAseq | -0.1844 | 0.3182 | |
| SRP133303 | DIS3 | 22894 | RNAseq | 0.2378 | 0.1387 | |
| SRP159526 | DIS3 | 22894 | RNAseq | -0.3767 | 0.2289 | |
| SRP193095 | DIS3 | 22894 | RNAseq | -0.1498 | 0.1297 | |
| SRP219564 | DIS3 | 22894 | RNAseq | -0.1104 | 0.7859 | |
| TCGA | DIS3 | 22894 | RNAseq | 0.0367 | 0.4439 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DIS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DIS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DIS3 | 22894 | 3 | 10 | 17 | |
| GSE20123 | DIS3 | 22894 | 3 | 9 | 18 | |
| GSE43470 | DIS3 | 22894 | 4 | 10 | 29 | |
| GSE46452 | DIS3 | 22894 | 2 | 31 | 26 | |
| GSE47630 | DIS3 | 22894 | 3 | 26 | 11 | |
| GSE54993 | DIS3 | 22894 | 11 | 3 | 56 | |
| GSE54994 | DIS3 | 22894 | 4 | 13 | 36 | |
| GSE60625 | DIS3 | 22894 | 0 | 3 | 8 | |
| GSE74703 | DIS3 | 22894 | 3 | 8 | 25 | |
| GSE74704 | DIS3 | 22894 | 1 | 8 | 11 | |
| TCGA | DIS3 | 22894 | 13 | 33 | 50 |
Total number of gains: 47; Total number of losses: 154; Total Number of normals: 287.
Somatic mutations of DIS3:
Generating mutation plots.
Highly correlated genes for DIS3:
Showing top 20/163 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DIS3 | ANKRD9 | 0.705247 | 3 | 0 | 3 |
| DIS3 | SHPRH | 0.697067 | 3 | 0 | 3 |
| DIS3 | NCKAP1 | 0.681838 | 3 | 0 | 3 |
| DIS3 | AGPS | 0.679751 | 4 | 0 | 3 |
| DIS3 | CEP97 | 0.674047 | 3 | 0 | 3 |
| DIS3 | LYRM7 | 0.667184 | 3 | 0 | 3 |
| DIS3 | GK5 | 0.665189 | 3 | 0 | 3 |
| DIS3 | IAH1 | 0.654447 | 3 | 0 | 3 |
| DIS3 | PIGW | 0.651851 | 3 | 0 | 3 |
| DIS3 | MYO3B | 0.649464 | 3 | 0 | 3 |
| DIS3 | UBE2E2 | 0.648629 | 3 | 0 | 3 |
| DIS3 | CENPL | 0.643896 | 3 | 0 | 3 |
| DIS3 | SNRNP25 | 0.637101 | 3 | 0 | 3 |
| DIS3 | MED28 | 0.622382 | 4 | 0 | 4 |
| DIS3 | NEDD8 | 0.621679 | 3 | 0 | 3 |
| DIS3 | LSM5 | 0.620081 | 4 | 0 | 3 |
| DIS3 | BCCIP | 0.617902 | 4 | 0 | 3 |
| DIS3 | NAA25 | 0.617703 | 3 | 0 | 3 |
| DIS3 | HSPA9 | 0.614846 | 3 | 0 | 3 |
| DIS3 | CINP | 0.613414 | 4 | 0 | 3 |
For details and further investigation, click here
