| Full name: LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated | Alias Symbol: YER146W | ||
| Type: protein-coding gene | Cytoband: 7p14.3 | ||
| Entrez ID: 23658 | HGNC ID: HGNC:17162 | Ensembl Gene: ENSG00000106355 | OMIM ID: 607285 |
| Drug and gene relationship at DGIdb | |||
Expression of LSM5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LSM5 | 23658 | 211747_s_at | 0.5451 | 0.2228 | |
| GSE20347 | LSM5 | 23658 | 211747_s_at | 0.9072 | 0.0000 | |
| GSE23400 | LSM5 | 23658 | 211747_s_at | 0.9805 | 0.0000 | |
| GSE26886 | LSM5 | 23658 | 211747_s_at | 1.4392 | 0.0000 | |
| GSE29001 | LSM5 | 23658 | 211747_s_at | 0.7362 | 0.1440 | |
| GSE38129 | LSM5 | 23658 | 211747_s_at | 1.0530 | 0.0000 | |
| GSE45670 | LSM5 | 23658 | 211747_s_at | 0.7391 | 0.0000 | |
| GSE53622 | LSM5 | 23658 | 20883 | 0.7381 | 0.0000 | |
| GSE53624 | LSM5 | 23658 | 20883 | 0.9324 | 0.0000 | |
| GSE63941 | LSM5 | 23658 | 211747_s_at | 0.9111 | 0.0012 | |
| GSE77861 | LSM5 | 23658 | 211747_s_at | 0.2589 | 0.3449 | |
| GSE97050 | LSM5 | 23658 | A_23_P93750 | 0.5971 | 0.1965 | |
| SRP007169 | LSM5 | 23658 | RNAseq | 1.1833 | 0.0750 | |
| SRP008496 | LSM5 | 23658 | RNAseq | 1.5969 | 0.0040 | |
| SRP064894 | LSM5 | 23658 | RNAseq | 0.5572 | 0.0361 | |
| SRP133303 | LSM5 | 23658 | RNAseq | 0.8149 | 0.0000 | |
| SRP159526 | LSM5 | 23658 | RNAseq | 0.7173 | 0.0012 | |
| SRP193095 | LSM5 | 23658 | RNAseq | 0.2963 | 0.0877 | |
| SRP219564 | LSM5 | 23658 | RNAseq | 0.4762 | 0.1995 | |
| TCGA | LSM5 | 23658 | RNAseq | 0.2076 | 0.0003 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by LSM5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LSM5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LSM5 | 23658 | 16 | 0 | 14 | |
| GSE20123 | LSM5 | 23658 | 16 | 0 | 14 | |
| GSE43470 | LSM5 | 23658 | 4 | 1 | 38 | |
| GSE46452 | LSM5 | 23658 | 11 | 1 | 47 | |
| GSE47630 | LSM5 | 23658 | 8 | 1 | 31 | |
| GSE54993 | LSM5 | 23658 | 0 | 6 | 64 | |
| GSE54994 | LSM5 | 23658 | 19 | 3 | 31 | |
| GSE60625 | LSM5 | 23658 | 0 | 0 | 11 | |
| GSE74703 | LSM5 | 23658 | 4 | 1 | 31 | |
| GSE74704 | LSM5 | 23658 | 10 | 0 | 10 | |
| TCGA | LSM5 | 23658 | 55 | 6 | 35 |
Total number of gains: 143; Total number of losses: 19; Total Number of normals: 326.
Somatic mutations of LSM5:
Generating mutation plots.
Highly correlated genes for LSM5:
Showing top 20/1866 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LSM5 | RPA3 | 0.796465 | 13 | 0 | 13 |
| LSM5 | RACGAP1 | 0.776642 | 11 | 0 | 11 |
| LSM5 | MMS22L | 0.775491 | 3 | 0 | 3 |
| LSM5 | ANLN | 0.766787 | 9 | 0 | 9 |
| LSM5 | MTHFD1L | 0.76531 | 3 | 0 | 3 |
| LSM5 | MRGBP | 0.762969 | 8 | 0 | 8 |
| LSM5 | PDE8A | 0.75732 | 4 | 0 | 4 |
| LSM5 | MRPL47 | 0.757301 | 7 | 0 | 7 |
| LSM5 | GMNN | 0.752796 | 13 | 0 | 12 |
| LSM5 | HRH1 | 0.751147 | 4 | 0 | 3 |
| LSM5 | AIMP2 | 0.750379 | 11 | 0 | 10 |
| LSM5 | GINS1 | 0.749214 | 12 | 0 | 11 |
| LSM5 | GMPS | 0.747443 | 11 | 0 | 10 |
| LSM5 | RFC2 | 0.745118 | 12 | 0 | 12 |
| LSM5 | ACLY | 0.743973 | 9 | 0 | 9 |
| LSM5 | MPLKIP | 0.743661 | 7 | 0 | 7 |
| LSM5 | CDKN3 | 0.741793 | 13 | 0 | 12 |
| LSM5 | CCNB2 | 0.739421 | 12 | 0 | 12 |
| LSM5 | CENPW | 0.738267 | 8 | 0 | 8 |
| LSM5 | CLSPN | 0.738084 | 6 | 0 | 6 |
For details and further investigation, click here
