| Full name: glyceraldehyde-3-phosphate dehydrogenase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 2597 | HGNC ID: HGNC:4141 | Ensembl Gene: ENSG00000111640 | OMIM ID: 138400 |
| Related drugs: DEFEROXAMINE, ESTRADIOL, MEDRONIC ACID, OMIGAPIL, SODIUM BUTYRATE, TAMOXIFEN... [more] | |||
Screen Evidence:
| |||
GAPDH involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | |
| hsa05010 | Alzheimer's disease |
Expression of GAPDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GAPDH | 2597 | 212581_x_at | 0.1737 | 0.4470 | |
| GSE20347 | GAPDH | 2597 | 212581_x_at | 0.1189 | 0.3005 | |
| GSE23400 | GAPDH | 2597 | 212581_x_at | 0.2084 | 0.0001 | |
| GSE26886 | GAPDH | 2597 | 212581_x_at | -0.1962 | 0.2196 | |
| GSE29001 | GAPDH | 2597 | 212581_x_at | -0.0620 | 0.8773 | |
| GSE38129 | GAPDH | 2597 | 212581_x_at | 0.1684 | 0.1214 | |
| GSE45670 | GAPDH | 2597 | 212581_x_at | 0.0983 | 0.5915 | |
| GSE63941 | GAPDH | 2597 | 212581_x_at | 0.7657 | 0.0010 | |
| GSE77861 | GAPDH | 2597 | 212581_x_at | 0.2098 | 0.2313 | |
| GSE97050 | GAPDH | 2597 | A_23_P13899 | 0.1545 | 0.5320 | |
| SRP007169 | GAPDH | 2597 | RNAseq | -0.2800 | 0.5960 | |
| SRP008496 | GAPDH | 2597 | RNAseq | -0.4188 | 0.2189 | |
| SRP064894 | GAPDH | 2597 | RNAseq | 0.1313 | 0.6004 | |
| SRP133303 | GAPDH | 2597 | RNAseq | 0.5410 | 0.0028 | |
| SRP159526 | GAPDH | 2597 | RNAseq | 0.1890 | 0.5918 | |
| SRP193095 | GAPDH | 2597 | RNAseq | -0.0007 | 0.9970 | |
| SRP219564 | GAPDH | 2597 | RNAseq | -0.1192 | 0.6526 | |
| TCGA | GAPDH | 2597 | RNAseq | 0.2458 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GAPDH expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GAPDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GAPDH | 2597 | 9 | 4 | 17 | |
| GSE20123 | GAPDH | 2597 | 9 | 4 | 17 | |
| GSE43470 | GAPDH | 2597 | 8 | 3 | 32 | |
| GSE46452 | GAPDH | 2597 | 10 | 1 | 48 | |
| GSE47630 | GAPDH | 2597 | 12 | 2 | 26 | |
| GSE54993 | GAPDH | 2597 | 1 | 10 | 59 | |
| GSE54994 | GAPDH | 2597 | 10 | 2 | 41 | |
| GSE60625 | GAPDH | 2597 | 0 | 1 | 10 | |
| GSE74703 | GAPDH | 2597 | 7 | 2 | 27 | |
| GSE74704 | GAPDH | 2597 | 5 | 3 | 12 | |
| TCGA | GAPDH | 2597 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 38; Total Number of normals: 339.
Somatic mutations of GAPDH:
Generating mutation plots.
Highly correlated genes for GAPDH:
Showing top 20/642 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GAPDH | EIF3F | 0.748362 | 3 | 0 | 3 |
| GAPDH | TPI1 | 0.746725 | 11 | 0 | 10 |
| GAPDH | PRELID1 | 0.74102 | 4 | 0 | 4 |
| GAPDH | NDUFA13 | 0.724015 | 3 | 0 | 3 |
| GAPDH | RPS19 | 0.716519 | 3 | 0 | 3 |
| GAPDH | SNAI3 | 0.715579 | 3 | 0 | 3 |
| GAPDH | IRF9 | 0.713816 | 3 | 0 | 3 |
| GAPDH | MLF2 | 0.712985 | 10 | 0 | 10 |
| GAPDH | AP1G2 | 0.707804 | 3 | 0 | 3 |
| GAPDH | RNF181 | 0.703544 | 4 | 0 | 4 |
| GAPDH | SHISA2 | 0.701875 | 3 | 0 | 3 |
| GAPDH | RPS14 | 0.701214 | 4 | 0 | 4 |
| GAPDH | PGRMC1 | 0.697575 | 3 | 0 | 3 |
| GAPDH | TMEM205 | 0.696809 | 4 | 0 | 3 |
| GAPDH | PPP1R18 | 0.69578 | 3 | 0 | 3 |
| GAPDH | DLL4 | 0.69499 | 3 | 0 | 3 |
| GAPDH | STRAP | 0.692861 | 8 | 0 | 8 |
| GAPDH | TCEANC2 | 0.68884 | 3 | 0 | 3 |
| GAPDH | MYPOP | 0.688445 | 3 | 0 | 3 |
| GAPDH | FUT8 | 0.685145 | 4 | 0 | 3 |
For details and further investigation, click here
