| Full name: serpin family A member 1 | Alias Symbol: AAT|A1A|PI1|alpha-1-antitrypsin|A1AT|alpha1AT | ||
| Type: protein-coding gene | Cytoband: 14q32.13 | ||
| Entrez ID: 5265 | HGNC ID: HGNC:8941 | Ensembl Gene: ENSG00000197249 | OMIM ID: 107400 |
| Drug and gene relationship at DGIdb | |||
SERPINA1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of SERPINA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINA1 | 5265 | 211429_s_at | 1.0923 | 0.4687 | |
| GSE20347 | SERPINA1 | 5265 | 211429_s_at | 0.6630 | 0.0140 | |
| GSE23400 | SERPINA1 | 5265 | 211429_s_at | 0.4845 | 0.0000 | |
| GSE26886 | SERPINA1 | 5265 | 211429_s_at | 1.0830 | 0.0273 | |
| GSE29001 | SERPINA1 | 5265 | 211429_s_at | 0.5764 | 0.0065 | |
| GSE38129 | SERPINA1 | 5265 | 211429_s_at | 0.8909 | 0.0047 | |
| GSE45670 | SERPINA1 | 5265 | 211429_s_at | 0.4086 | 0.3317 | |
| GSE53622 | SERPINA1 | 5265 | 54723 | 0.5370 | 0.0002 | |
| GSE53624 | SERPINA1 | 5265 | 54723 | 0.3097 | 0.0001 | |
| GSE63941 | SERPINA1 | 5265 | 211429_s_at | 1.0948 | 0.2937 | |
| GSE77861 | SERPINA1 | 5265 | 230318_at | -0.1123 | 0.4360 | |
| GSE97050 | SERPINA1 | 5265 | A_23_P218111 | 1.1159 | 0.1507 | |
| SRP007169 | SERPINA1 | 5265 | RNAseq | 3.9126 | 0.0000 | |
| SRP008496 | SERPINA1 | 5265 | RNAseq | 3.1527 | 0.0000 | |
| SRP064894 | SERPINA1 | 5265 | RNAseq | 0.9262 | 0.0503 | |
| SRP133303 | SERPINA1 | 5265 | RNAseq | 1.5423 | 0.0020 | |
| SRP159526 | SERPINA1 | 5265 | RNAseq | 1.0569 | 0.1391 | |
| SRP193095 | SERPINA1 | 5265 | RNAseq | 0.2235 | 0.6841 | |
| SRP219564 | SERPINA1 | 5265 | RNAseq | 2.5017 | 0.0002 | |
| TCGA | SERPINA1 | 5265 | RNAseq | -0.4509 | 0.0050 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by SERPINA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINA1 | 5265 | 9 | 4 | 17 | |
| GSE20123 | SERPINA1 | 5265 | 9 | 3 | 18 | |
| GSE43470 | SERPINA1 | 5265 | 7 | 3 | 33 | |
| GSE46452 | SERPINA1 | 5265 | 16 | 3 | 40 | |
| GSE47630 | SERPINA1 | 5265 | 11 | 8 | 21 | |
| GSE54993 | SERPINA1 | 5265 | 3 | 8 | 59 | |
| GSE54994 | SERPINA1 | 5265 | 21 | 4 | 28 | |
| GSE60625 | SERPINA1 | 5265 | 0 | 2 | 9 | |
| GSE74703 | SERPINA1 | 5265 | 6 | 3 | 27 | |
| GSE74704 | SERPINA1 | 5265 | 5 | 3 | 12 | |
| TCGA | SERPINA1 | 5265 | 30 | 20 | 46 |
Total number of gains: 117; Total number of losses: 61; Total Number of normals: 310.
Somatic mutations of SERPINA1:
Generating mutation plots.
Highly correlated genes for SERPINA1:
Showing top 20/371 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINA1 | PIK3AP1 | 0.808255 | 3 | 0 | 3 |
| SERPINA1 | PPP1R16B | 0.803817 | 3 | 0 | 3 |
| SERPINA1 | RPS6KA4 | 0.762836 | 3 | 0 | 3 |
| SERPINA1 | ST6GALNAC4 | 0.740404 | 3 | 0 | 3 |
| SERPINA1 | PRSS36 | 0.733237 | 3 | 0 | 3 |
| SERPINA1 | FCER1G | 0.729743 | 9 | 0 | 7 |
| SERPINA1 | CD86 | 0.718582 | 8 | 0 | 7 |
| SERPINA1 | ZNF789 | 0.718226 | 3 | 0 | 3 |
| SERPINA1 | SLC4A8 | 0.71322 | 3 | 0 | 3 |
| SERPINA1 | LCP2 | 0.706414 | 9 | 0 | 8 |
| SERPINA1 | FCGR3B | 0.698953 | 7 | 0 | 6 |
| SERPINA1 | C16orf54 | 0.695586 | 4 | 0 | 3 |
| SERPINA1 | ITGB2 | 0.692983 | 8 | 0 | 7 |
| SERPINA1 | GK | 0.691273 | 3 | 0 | 3 |
| SERPINA1 | SUSD3 | 0.688644 | 3 | 0 | 3 |
| SERPINA1 | C5AR1 | 0.688566 | 9 | 0 | 7 |
| SERPINA1 | CLEC11A | 0.68781 | 4 | 0 | 4 |
| SERPINA1 | FCGR2A | 0.684709 | 10 | 0 | 7 |
| SERPINA1 | ADAM32 | 0.683403 | 3 | 0 | 3 |
| SERPINA1 | DDX27 | 0.683267 | 3 | 0 | 3 |
For details and further investigation, click here
