| Full name: dynein axonemal heavy chain 3 | Alias Symbol: Dnahc3b|DLP3|Hsadhc3|DKFZp434N074 | ||
| Type: protein-coding gene | Cytoband: 16p12.3 | ||
| Entrez ID: 55567 | HGNC ID: HGNC:2949 | Ensembl Gene: ENSG00000158486 | OMIM ID: 603334 |
| Drug and gene relationship at DGIdb | |||
Expression of DNAH3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNAH3 | 55567 | 220725_x_at | -0.0309 | 0.9284 | |
| GSE20347 | DNAH3 | 55567 | 220725_x_at | 0.1294 | 0.4575 | |
| GSE23400 | DNAH3 | 55567 | 215266_at | -0.1157 | 0.0005 | |
| GSE26886 | DNAH3 | 55567 | 215266_at | 0.0841 | 0.5696 | |
| GSE29001 | DNAH3 | 55567 | 220725_x_at | -0.3474 | 0.0339 | |
| GSE38129 | DNAH3 | 55567 | 220725_x_at | -0.1257 | 0.6447 | |
| GSE45670 | DNAH3 | 55567 | 220725_x_at | -0.0386 | 0.7202 | |
| GSE53622 | DNAH3 | 55567 | 47846 | 1.1177 | 0.0000 | |
| GSE53624 | DNAH3 | 55567 | 47846 | 1.1293 | 0.0000 | |
| GSE63941 | DNAH3 | 55567 | 220725_x_at | 0.8296 | 0.0018 | |
| GSE77861 | DNAH3 | 55567 | 220725_x_at | -0.2131 | 0.1695 | |
| GSE97050 | DNAH3 | 55567 | A_33_P3218704 | 0.0068 | 0.9801 | |
| SRP133303 | DNAH3 | 55567 | RNAseq | 1.3520 | 0.0092 | |
| SRP193095 | DNAH3 | 55567 | RNAseq | 0.2276 | 0.2967 | |
| SRP219564 | DNAH3 | 55567 | RNAseq | 0.4507 | 0.4331 | |
| TCGA | DNAH3 | 55567 | RNAseq | 2.0125 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by DNAH3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNAH3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNAH3 | 55567 | 6 | 3 | 21 | |
| GSE20123 | DNAH3 | 55567 | 6 | 2 | 22 | |
| GSE43470 | DNAH3 | 55567 | 3 | 3 | 37 | |
| GSE46452 | DNAH3 | 55567 | 38 | 1 | 20 | |
| GSE47630 | DNAH3 | 55567 | 11 | 6 | 23 | |
| GSE54993 | DNAH3 | 55567 | 3 | 5 | 62 | |
| GSE54994 | DNAH3 | 55567 | 3 | 10 | 40 | |
| GSE60625 | DNAH3 | 55567 | 4 | 0 | 7 | |
| GSE74703 | DNAH3 | 55567 | 3 | 2 | 31 | |
| GSE74704 | DNAH3 | 55567 | 3 | 1 | 16 | |
| TCGA | DNAH3 | 55567 | 19 | 13 | 64 |
Total number of gains: 99; Total number of losses: 46; Total Number of normals: 343.
Somatic mutations of DNAH3:
Generating mutation plots.
Highly correlated genes for DNAH3:
Showing top 20/475 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNAH3 | OPHN1 | 0.841597 | 7 | 0 | 7 |
| DNAH3 | XRCC2 | 0.750005 | 3 | 0 | 3 |
| DNAH3 | MTAP | 0.721515 | 4 | 0 | 4 |
| DNAH3 | MED24 | 0.719265 | 4 | 0 | 4 |
| DNAH3 | ZNF460 | 0.713185 | 5 | 0 | 4 |
| DNAH3 | FCGR2C | 0.712663 | 3 | 0 | 3 |
| DNAH3 | FOLH1 | 0.706807 | 5 | 0 | 4 |
| DNAH3 | FBXW12 | 0.695393 | 3 | 0 | 3 |
| DNAH3 | ATG10 | 0.69324 | 5 | 0 | 4 |
| DNAH3 | LINC01361 | 0.672368 | 3 | 0 | 3 |
| DNAH3 | ESR2 | 0.670737 | 3 | 0 | 3 |
| DNAH3 | EDA2R | 0.670011 | 5 | 0 | 4 |
| DNAH3 | KRTAP5-8 | 0.669474 | 4 | 0 | 3 |
| DNAH3 | KIR2DS2 | 0.668854 | 4 | 0 | 4 |
| DNAH3 | POLM | 0.667196 | 3 | 0 | 3 |
| DNAH3 | CA7 | 0.666315 | 5 | 0 | 5 |
| DNAH3 | ODF1 | 0.665509 | 5 | 0 | 4 |
| DNAH3 | GK2 | 0.665 | 4 | 0 | 4 |
| DNAH3 | SMCP | 0.661896 | 5 | 0 | 4 |
| DNAH3 | OR2C1 | 0.661843 | 5 | 0 | 4 |
For details and further investigation, click here
