| Full name: deoxyribonuclease 1 like 3 | Alias Symbol: DNAS1L3|LSD | ||
| Type: protein-coding gene | Cytoband: 3p14.3 | ||
| Entrez ID: 1776 | HGNC ID: HGNC:2959 | Ensembl Gene: ENSG00000163687 | OMIM ID: 602244 |
| Drug and gene relationship at DGIdb | |||
Expression of DNASE1L3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNASE1L3 | 1776 | 205554_s_at | -1.9119 | 0.1557 | |
| GSE20347 | DNASE1L3 | 1776 | 205554_s_at | -2.1219 | 0.0000 | |
| GSE23400 | DNASE1L3 | 1776 | 205554_s_at | -0.8457 | 0.0000 | |
| GSE26886 | DNASE1L3 | 1776 | 205554_s_at | -2.6084 | 0.0000 | |
| GSE29001 | DNASE1L3 | 1776 | 205554_s_at | -1.7376 | 0.0005 | |
| GSE38129 | DNASE1L3 | 1776 | 205554_s_at | -1.8073 | 0.0000 | |
| GSE45670 | DNASE1L3 | 1776 | 205554_s_at | 0.0134 | 0.9883 | |
| GSE53622 | DNASE1L3 | 1776 | 83075 | -2.8246 | 0.0000 | |
| GSE53624 | DNASE1L3 | 1776 | 83075 | -3.2323 | 0.0000 | |
| GSE63941 | DNASE1L3 | 1776 | 1561336_at | 0.3118 | 0.0585 | |
| GSE77861 | DNASE1L3 | 1776 | 205554_s_at | -1.5781 | 0.0025 | |
| GSE97050 | DNASE1L3 | 1776 | A_33_P3234202 | -0.3720 | 0.4917 | |
| SRP007169 | DNASE1L3 | 1776 | RNAseq | -4.0393 | 0.0000 | |
| SRP064894 | DNASE1L3 | 1776 | RNAseq | -2.9322 | 0.0000 | |
| SRP133303 | DNASE1L3 | 1776 | RNAseq | -1.6687 | 0.0003 | |
| SRP159526 | DNASE1L3 | 1776 | RNAseq | -2.1583 | 0.0315 | |
| SRP193095 | DNASE1L3 | 1776 | RNAseq | -1.9545 | 0.0000 | |
| SRP219564 | DNASE1L3 | 1776 | RNAseq | -2.7412 | 0.0003 | |
| TCGA | DNASE1L3 | 1776 | RNAseq | 0.1933 | 0.5845 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by DNASE1L3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNASE1L3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNASE1L3 | 1776 | 0 | 17 | 13 | |
| GSE20123 | DNASE1L3 | 1776 | 0 | 18 | 12 | |
| GSE43470 | DNASE1L3 | 1776 | 0 | 17 | 26 | |
| GSE46452 | DNASE1L3 | 1776 | 2 | 17 | 40 | |
| GSE47630 | DNASE1L3 | 1776 | 1 | 24 | 15 | |
| GSE54993 | DNASE1L3 | 1776 | 6 | 2 | 62 | |
| GSE54994 | DNASE1L3 | 1776 | 0 | 32 | 21 | |
| GSE60625 | DNASE1L3 | 1776 | 5 | 0 | 6 | |
| GSE74703 | DNASE1L3 | 1776 | 0 | 14 | 22 | |
| GSE74704 | DNASE1L3 | 1776 | 0 | 11 | 9 | |
| TCGA | DNASE1L3 | 1776 | 0 | 79 | 17 |
Total number of gains: 14; Total number of losses: 231; Total Number of normals: 243.
Somatic mutations of DNASE1L3:
Generating mutation plots.
Highly correlated genes for DNASE1L3:
Showing top 20/1385 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNASE1L3 | ATP13A4 | 0.781509 | 6 | 0 | 6 |
| DNASE1L3 | FAM3D | 0.776558 | 6 | 0 | 6 |
| DNASE1L3 | IL18 | 0.773919 | 9 | 0 | 9 |
| DNASE1L3 | CYSRT1 | 0.769165 | 6 | 0 | 5 |
| DNASE1L3 | LTA4H | 0.764629 | 3 | 0 | 3 |
| DNASE1L3 | GLTP | 0.759829 | 8 | 0 | 8 |
| DNASE1L3 | CXCR2 | 0.75643 | 11 | 0 | 11 |
| DNASE1L3 | CD1E | 0.75567 | 3 | 0 | 3 |
| DNASE1L3 | NIPAL1 | 0.750925 | 3 | 0 | 3 |
| DNASE1L3 | RDH12 | 0.749615 | 7 | 0 | 6 |
| DNASE1L3 | ENDOU | 0.748796 | 11 | 0 | 10 |
| DNASE1L3 | EMP1 | 0.743777 | 9 | 0 | 9 |
| DNASE1L3 | UPK3B | 0.742624 | 3 | 0 | 3 |
| DNASE1L3 | TGM1 | 0.742296 | 12 | 0 | 11 |
| DNASE1L3 | DEGS2 | 0.741433 | 5 | 0 | 5 |
| DNASE1L3 | TTC9 | 0.740593 | 10 | 0 | 10 |
| DNASE1L3 | EPGN | 0.740457 | 3 | 0 | 3 |
| DNASE1L3 | MCEE | 0.739705 | 7 | 0 | 6 |
| DNASE1L3 | CA13 | 0.738825 | 3 | 0 | 3 |
| DNASE1L3 | CWH43 | 0.736196 | 10 | 0 | 10 |
For details and further investigation, click here
