| Full name: dedicator of cytokinesis 6 | Alias Symbol: KIAA1395|ZIR1 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 57572 | HGNC ID: HGNC:19189 | Ensembl Gene: ENSG00000130158 | OMIM ID: 614194 |
| Drug and gene relationship at DGIdb | |||
Expression of DOCK6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOCK6 | 57572 | 55583_at | 0.4054 | 0.1955 | |
| GSE20347 | DOCK6 | 57572 | 55583_at | -0.1265 | 0.3272 | |
| GSE23400 | DOCK6 | 57572 | 221794_at | 0.0100 | 0.8788 | |
| GSE26886 | DOCK6 | 57572 | 221794_at | -0.0582 | 0.8187 | |
| GSE29001 | DOCK6 | 57572 | 221794_at | -0.0266 | 0.9382 | |
| GSE38129 | DOCK6 | 57572 | 55583_at | -0.0812 | 0.4154 | |
| GSE45670 | DOCK6 | 57572 | 55583_at | 0.3668 | 0.0131 | |
| GSE53622 | DOCK6 | 57572 | 41908 | 0.0103 | 0.9027 | |
| GSE53624 | DOCK6 | 57572 | 41908 | 0.0072 | 0.9203 | |
| GSE63941 | DOCK6 | 57572 | 55583_at | 0.3747 | 0.2937 | |
| GSE77861 | DOCK6 | 57572 | 55583_at | 0.3029 | 0.0650 | |
| GSE97050 | DOCK6 | 57572 | A_23_P67299 | 0.2416 | 0.3012 | |
| SRP007169 | DOCK6 | 57572 | RNAseq | 0.3098 | 0.5098 | |
| SRP008496 | DOCK6 | 57572 | RNAseq | 0.0526 | 0.8654 | |
| SRP064894 | DOCK6 | 57572 | RNAseq | 0.4203 | 0.0094 | |
| SRP133303 | DOCK6 | 57572 | RNAseq | -0.1286 | 0.4666 | |
| SRP159526 | DOCK6 | 57572 | RNAseq | -0.2102 | 0.4252 | |
| SRP193095 | DOCK6 | 57572 | RNAseq | 0.0587 | 0.6928 | |
| SRP219564 | DOCK6 | 57572 | RNAseq | 0.1964 | 0.4535 | |
| TCGA | DOCK6 | 57572 | RNAseq | -0.0192 | 0.7368 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DOCK6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOCK6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOCK6 | 57572 | 4 | 2 | 24 | |
| GSE20123 | DOCK6 | 57572 | 3 | 1 | 26 | |
| GSE43470 | DOCK6 | 57572 | 2 | 6 | 35 | |
| GSE46452 | DOCK6 | 57572 | 47 | 1 | 11 | |
| GSE47630 | DOCK6 | 57572 | 4 | 7 | 29 | |
| GSE54993 | DOCK6 | 57572 | 16 | 3 | 51 | |
| GSE54994 | DOCK6 | 57572 | 6 | 13 | 34 | |
| GSE60625 | DOCK6 | 57572 | 9 | 0 | 2 | |
| GSE74703 | DOCK6 | 57572 | 2 | 4 | 30 | |
| GSE74704 | DOCK6 | 57572 | 0 | 1 | 19 | |
| TCGA | DOCK6 | 57572 | 16 | 12 | 68 |
Total number of gains: 109; Total number of losses: 50; Total Number of normals: 329.
Somatic mutations of DOCK6:
Generating mutation plots.
Highly correlated genes for DOCK6:
Showing top 20/744 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOCK6 | POMGNT1 | 0.81963 | 3 | 0 | 3 |
| DOCK6 | GORAB | 0.806186 | 3 | 0 | 3 |
| DOCK6 | URB2 | 0.803465 | 3 | 0 | 3 |
| DOCK6 | PRDM15 | 0.794062 | 3 | 0 | 3 |
| DOCK6 | DEDD | 0.7925 | 3 | 0 | 3 |
| DOCK6 | DDX23 | 0.776729 | 4 | 0 | 4 |
| DOCK6 | THADA | 0.775913 | 3 | 0 | 3 |
| DOCK6 | SLC25A19 | 0.773164 | 3 | 0 | 3 |
| DOCK6 | WDR54 | 0.764475 | 3 | 0 | 3 |
| DOCK6 | HGS | 0.763719 | 6 | 0 | 6 |
| DOCK6 | SF3B2 | 0.76017 | 4 | 0 | 3 |
| DOCK6 | FPGS | 0.759793 | 3 | 0 | 3 |
| DOCK6 | PSPC1 | 0.757878 | 3 | 0 | 3 |
| DOCK6 | URM1 | 0.757464 | 3 | 0 | 3 |
| DOCK6 | HEATR6 | 0.754673 | 3 | 0 | 3 |
| DOCK6 | LIMK1 | 0.754162 | 4 | 0 | 4 |
| DOCK6 | ZFYVE27 | 0.752472 | 3 | 0 | 3 |
| DOCK6 | PTBP1 | 0.751933 | 4 | 0 | 4 |
| DOCK6 | PRCC | 0.751667 | 4 | 0 | 4 |
| DOCK6 | ZBTB9 | 0.750608 | 3 | 0 | 3 |
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