| Full name: folylpolyglutamate synthase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 2356 | HGNC ID: HGNC:3824 | Ensembl Gene: ENSG00000136877 | OMIM ID: 136510 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FPGS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FPGS | 2356 | 202945_at | 0.4019 | 0.1308 | |
| GSE20347 | FPGS | 2356 | 202945_at | 0.2249 | 0.0138 | |
| GSE23400 | FPGS | 2356 | 202945_at | 0.1733 | 0.0002 | |
| GSE26886 | FPGS | 2356 | 202945_at | 0.6590 | 0.0002 | |
| GSE29001 | FPGS | 2356 | 202945_at | -0.1058 | 0.5368 | |
| GSE38129 | FPGS | 2356 | 202945_at | 0.1840 | 0.0431 | |
| GSE45670 | FPGS | 2356 | 202945_at | 0.1689 | 0.1779 | |
| GSE53622 | FPGS | 2356 | 5238 | 0.5023 | 0.0000 | |
| GSE53624 | FPGS | 2356 | 5238 | 0.3284 | 0.0000 | |
| GSE63941 | FPGS | 2356 | 202945_at | 0.2364 | 0.4658 | |
| GSE77861 | FPGS | 2356 | 202945_at | 0.0311 | 0.8209 | |
| GSE97050 | FPGS | 2356 | A_33_P3394198 | 0.0512 | 0.8918 | |
| SRP007169 | FPGS | 2356 | RNAseq | -0.9129 | 0.0268 | |
| SRP008496 | FPGS | 2356 | RNAseq | -0.6987 | 0.0064 | |
| SRP064894 | FPGS | 2356 | RNAseq | 0.6766 | 0.0146 | |
| SRP133303 | FPGS | 2356 | RNAseq | 0.4518 | 0.0373 | |
| SRP159526 | FPGS | 2356 | RNAseq | 0.2702 | 0.2610 | |
| SRP193095 | FPGS | 2356 | RNAseq | 0.7554 | 0.0000 | |
| SRP219564 | FPGS | 2356 | RNAseq | 0.2478 | 0.2828 | |
| TCGA | FPGS | 2356 | RNAseq | 0.1266 | 0.0439 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FPGS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FPGS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FPGS | 2356 | 6 | 9 | 15 | |
| GSE20123 | FPGS | 2356 | 6 | 9 | 15 | |
| GSE43470 | FPGS | 2356 | 5 | 6 | 32 | |
| GSE46452 | FPGS | 2356 | 6 | 13 | 40 | |
| GSE47630 | FPGS | 2356 | 3 | 16 | 21 | |
| GSE54993 | FPGS | 2356 | 3 | 3 | 64 | |
| GSE54994 | FPGS | 2356 | 11 | 8 | 34 | |
| GSE60625 | FPGS | 2356 | 0 | 0 | 11 | |
| GSE74703 | FPGS | 2356 | 5 | 4 | 27 | |
| GSE74704 | FPGS | 2356 | 3 | 7 | 10 | |
| TCGA | FPGS | 2356 | 27 | 25 | 44 |
Total number of gains: 75; Total number of losses: 100; Total Number of normals: 313.
Somatic mutations of FPGS:
Generating mutation plots.
Highly correlated genes for FPGS:
Showing top 20/651 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FPGS | TUBGCP2 | 0.781523 | 3 | 0 | 3 |
| FPGS | DOCK6 | 0.759793 | 3 | 0 | 3 |
| FPGS | TRAPPC1 | 0.759501 | 3 | 0 | 3 |
| FPGS | IFI27L2 | 0.759437 | 3 | 0 | 3 |
| FPGS | RAB1B | 0.737975 | 3 | 0 | 3 |
| FPGS | MIF | 0.736557 | 3 | 0 | 3 |
| FPGS | KCNN1 | 0.732089 | 3 | 0 | 3 |
| FPGS | ANKRD54 | 0.726759 | 3 | 0 | 3 |
| FPGS | PHPT1 | 0.719842 | 3 | 0 | 3 |
| FPGS | RIOK1 | 0.710765 | 3 | 0 | 3 |
| FPGS | COL1A1 | 0.702071 | 3 | 0 | 3 |
| FPGS | DDX24 | 0.70157 | 3 | 0 | 3 |
| FPGS | LSM10 | 0.700637 | 3 | 0 | 3 |
| FPGS | DYNC1H1 | 0.698717 | 4 | 0 | 4 |
| FPGS | ZNF628 | 0.695705 | 3 | 0 | 3 |
| FPGS | SLC25A1 | 0.694992 | 4 | 0 | 3 |
| FPGS | NDUFB4 | 0.694147 | 4 | 0 | 4 |
| FPGS | NEK6 | 0.691932 | 3 | 0 | 3 |
| FPGS | NKX2-2 | 0.690316 | 4 | 0 | 3 |
| FPGS | NADSYN1 | 0.68915 | 3 | 0 | 3 |
For details and further investigation, click here
