| Full name: splicing factor 3b subunit 2 | Alias Symbol: SAP145|SF3b1|Cus1|SF3b145 | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 10992 | HGNC ID: HGNC:10769 | Ensembl Gene: ENSG00000087365 | OMIM ID: 605591 |
| Drug and gene relationship at DGIdb | |||
Expression of SF3B2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SF3B2 | 10992 | 200619_at | 0.5030 | 0.0943 | |
| GSE20347 | SF3B2 | 10992 | 200619_at | 0.5548 | 0.0015 | |
| GSE23400 | SF3B2 | 10992 | 200619_at | 0.4543 | 0.0000 | |
| GSE26886 | SF3B2 | 10992 | 200619_at | 0.8503 | 0.0000 | |
| GSE29001 | SF3B2 | 10992 | 200619_at | 0.2838 | 0.1225 | |
| GSE38129 | SF3B2 | 10992 | 200619_at | 0.4166 | 0.0009 | |
| GSE45670 | SF3B2 | 10992 | 200619_at | 0.2435 | 0.1173 | |
| GSE53622 | SF3B2 | 10992 | 59941 | 0.4343 | 0.0000 | |
| GSE53624 | SF3B2 | 10992 | 59941 | 0.6322 | 0.0000 | |
| GSE63941 | SF3B2 | 10992 | 200619_at | 0.3391 | 0.3704 | |
| GSE77861 | SF3B2 | 10992 | 200619_at | 0.7100 | 0.0025 | |
| GSE97050 | SF3B2 | 10992 | A_23_P64083 | 0.4279 | 0.2431 | |
| SRP007169 | SF3B2 | 10992 | RNAseq | 1.9681 | 0.0002 | |
| SRP008496 | SF3B2 | 10992 | RNAseq | 1.5610 | 0.0000 | |
| SRP064894 | SF3B2 | 10992 | RNAseq | 0.2418 | 0.0077 | |
| SRP133303 | SF3B2 | 10992 | RNAseq | 0.5497 | 0.0090 | |
| SRP159526 | SF3B2 | 10992 | RNAseq | 0.4336 | 0.0379 | |
| SRP193095 | SF3B2 | 10992 | RNAseq | 0.4538 | 0.0000 | |
| SRP219564 | SF3B2 | 10992 | RNAseq | 0.2931 | 0.4047 | |
| TCGA | SF3B2 | 10992 | RNAseq | 0.0568 | 0.1641 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SF3B2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SF3B2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SF3B2 | 10992 | 9 | 4 | 17 | |
| GSE20123 | SF3B2 | 10992 | 9 | 4 | 17 | |
| GSE43470 | SF3B2 | 10992 | 6 | 1 | 36 | |
| GSE46452 | SF3B2 | 10992 | 11 | 3 | 45 | |
| GSE47630 | SF3B2 | 10992 | 7 | 5 | 28 | |
| GSE54993 | SF3B2 | 10992 | 3 | 0 | 67 | |
| GSE54994 | SF3B2 | 10992 | 8 | 5 | 40 | |
| GSE60625 | SF3B2 | 10992 | 0 | 3 | 8 | |
| GSE74703 | SF3B2 | 10992 | 4 | 0 | 32 | |
| GSE74704 | SF3B2 | 10992 | 7 | 2 | 11 | |
| TCGA | SF3B2 | 10992 | 24 | 6 | 66 |
Total number of gains: 88; Total number of losses: 33; Total Number of normals: 367.
Somatic mutations of SF3B2:
Generating mutation plots.
Highly correlated genes for SF3B2:
Showing top 20/1946 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SF3B2 | SPIRE1 | 0.798798 | 3 | 0 | 3 |
| SF3B2 | LSM14B | 0.792132 | 3 | 0 | 3 |
| SF3B2 | NSD1 | 0.789622 | 3 | 0 | 3 |
| SF3B2 | TRIM47 | 0.773374 | 3 | 0 | 3 |
| SF3B2 | TRADD | 0.766939 | 3 | 0 | 3 |
| SF3B2 | DOCK6 | 0.76017 | 4 | 0 | 3 |
| SF3B2 | WDR54 | 0.757626 | 6 | 0 | 6 |
| SF3B2 | BANF1 | 0.756708 | 12 | 0 | 11 |
| SF3B2 | FIBP | 0.754721 | 12 | 0 | 12 |
| SF3B2 | TMEM41A | 0.752076 | 3 | 0 | 3 |
| SF3B2 | CD276 | 0.750439 | 4 | 0 | 3 |
| SF3B2 | MRPL38 | 0.747285 | 3 | 0 | 3 |
| SF3B2 | NPLOC4 | 0.746923 | 3 | 0 | 3 |
| SF3B2 | PRDM15 | 0.745936 | 3 | 0 | 3 |
| SF3B2 | CRTC2 | 0.743985 | 4 | 0 | 4 |
| SF3B2 | FHL3 | 0.743277 | 3 | 0 | 3 |
| SF3B2 | WDR81 | 0.736996 | 3 | 0 | 3 |
| SF3B2 | SCYL1 | 0.735042 | 6 | 0 | 5 |
| SF3B2 | PPP1R9B | 0.732739 | 3 | 0 | 3 |
| SF3B2 | PHRF1 | 0.730329 | 3 | 0 | 3 |
For details and further investigation, click here
