| Full name: mannosidase alpha class 1C member 1 | Alias Symbol: HMIC | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 57134 | HGNC ID: HGNC:19080 | Ensembl Gene: ENSG00000117643 | OMIM ID: 616772 |
| Drug and gene relationship at DGIdb | |||
Expression of MAN1C1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAN1C1 | 57134 | 218918_at | -1.0774 | 0.2404 | |
| GSE20347 | MAN1C1 | 57134 | 214180_at | -0.0642 | 0.5921 | |
| GSE23400 | MAN1C1 | 57134 | 214180_at | -0.1212 | 0.0249 | |
| GSE26886 | MAN1C1 | 57134 | 218918_at | 0.3470 | 0.3358 | |
| GSE29001 | MAN1C1 | 57134 | 214180_at | -0.3860 | 0.0969 | |
| GSE38129 | MAN1C1 | 57134 | 214180_at | -0.4356 | 0.0725 | |
| GSE45670 | MAN1C1 | 57134 | 218918_at | -1.7789 | 0.0001 | |
| GSE53622 | MAN1C1 | 57134 | 29589 | -0.9965 | 0.0000 | |
| GSE53624 | MAN1C1 | 57134 | 47302 | -1.0587 | 0.0000 | |
| GSE63941 | MAN1C1 | 57134 | 218918_at | -4.8818 | 0.0000 | |
| GSE77861 | MAN1C1 | 57134 | 214180_at | -0.0200 | 0.8820 | |
| GSE97050 | MAN1C1 | 57134 | A_24_P237778 | -0.4121 | 0.1811 | |
| SRP007169 | MAN1C1 | 57134 | RNAseq | 0.0398 | 0.9425 | |
| SRP064894 | MAN1C1 | 57134 | RNAseq | -0.2042 | 0.5501 | |
| SRP133303 | MAN1C1 | 57134 | RNAseq | -0.9399 | 0.0036 | |
| SRP159526 | MAN1C1 | 57134 | RNAseq | 0.0046 | 0.9935 | |
| SRP193095 | MAN1C1 | 57134 | RNAseq | -0.1736 | 0.3490 | |
| SRP219564 | MAN1C1 | 57134 | RNAseq | -0.0974 | 0.9192 | |
| TCGA | MAN1C1 | 57134 | RNAseq | -0.6616 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by MAN1C1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAN1C1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAN1C1 | 57134 | 0 | 5 | 25 | |
| GSE20123 | MAN1C1 | 57134 | 0 | 4 | 26 | |
| GSE43470 | MAN1C1 | 57134 | 2 | 6 | 35 | |
| GSE46452 | MAN1C1 | 57134 | 5 | 1 | 53 | |
| GSE47630 | MAN1C1 | 57134 | 8 | 3 | 29 | |
| GSE54993 | MAN1C1 | 57134 | 2 | 1 | 67 | |
| GSE54994 | MAN1C1 | 57134 | 10 | 4 | 39 | |
| GSE60625 | MAN1C1 | 57134 | 0 | 0 | 11 | |
| GSE74703 | MAN1C1 | 57134 | 1 | 4 | 31 | |
| GSE74704 | MAN1C1 | 57134 | 0 | 0 | 20 | |
| TCGA | MAN1C1 | 57134 | 9 | 24 | 63 |
Total number of gains: 37; Total number of losses: 52; Total Number of normals: 399.
Somatic mutations of MAN1C1:
Generating mutation plots.
Highly correlated genes for MAN1C1:
Showing top 20/1412 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAN1C1 | AFF3 | 0.881881 | 3 | 0 | 3 |
| MAN1C1 | FZD7 | 0.809071 | 3 | 0 | 3 |
| MAN1C1 | KCNT2 | 0.800103 | 6 | 0 | 6 |
| MAN1C1 | PARD3B | 0.798149 | 5 | 0 | 5 |
| MAN1C1 | FRMD3 | 0.796276 | 5 | 0 | 5 |
| MAN1C1 | CLEC3B | 0.785101 | 3 | 0 | 3 |
| MAN1C1 | C1QTNF7 | 0.783262 | 5 | 0 | 5 |
| MAN1C1 | LRRK2 | 0.778339 | 6 | 0 | 6 |
| MAN1C1 | ANKRD44 | 0.777636 | 6 | 0 | 6 |
| MAN1C1 | GIMAP7 | 0.77686 | 5 | 0 | 5 |
| MAN1C1 | TMEM170B | 0.770259 | 7 | 0 | 7 |
| MAN1C1 | BEND5 | 0.769725 | 6 | 0 | 6 |
| MAN1C1 | C1orf216 | 0.765805 | 3 | 0 | 3 |
| MAN1C1 | MSRB3 | 0.765303 | 6 | 0 | 6 |
| MAN1C1 | TCEAL6 | 0.758595 | 3 | 0 | 3 |
| MAN1C1 | CYP21A2 | 0.758117 | 3 | 0 | 3 |
| MAN1C1 | SMTNL2 | 0.758096 | 5 | 0 | 5 |
| MAN1C1 | GIMAP5 | 0.757163 | 3 | 0 | 3 |
| MAN1C1 | GNG2 | 0.754943 | 5 | 0 | 5 |
| MAN1C1 | FZD4 | 0.751898 | 10 | 0 | 10 |
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