| Full name: SEC62 homolog, preprotein translocation factor | Alias Symbol: Dtrp1|HTP1 | ||
| Type: protein-coding gene | Cytoband: 3q26.2 | ||
| Entrez ID: 7095 | HGNC ID: HGNC:11846 | Ensembl Gene: ENSG00000008952 | OMIM ID: 602173 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SEC62:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC62 | 7095 | 208942_s_at | -0.0064 | 0.9948 | |
| GSE20347 | SEC62 | 7095 | 208942_s_at | 0.7201 | 0.0000 | |
| GSE23400 | SEC62 | 7095 | 208942_s_at | 0.4287 | 0.0017 | |
| GSE26886 | SEC62 | 7095 | 208942_s_at | 1.8553 | 0.0000 | |
| GSE29001 | SEC62 | 7095 | 208942_s_at | 0.6913 | 0.0057 | |
| GSE38129 | SEC62 | 7095 | 208942_s_at | 0.3061 | 0.1134 | |
| GSE45670 | SEC62 | 7095 | 208942_s_at | 0.1058 | 0.6096 | |
| GSE53622 | SEC62 | 7095 | 72810 | 0.1942 | 0.0117 | |
| GSE53624 | SEC62 | 7095 | 72810 | 0.5767 | 0.0000 | |
| GSE63941 | SEC62 | 7095 | 208942_s_at | -0.2011 | 0.6757 | |
| GSE77861 | SEC62 | 7095 | 208942_s_at | 0.8792 | 0.0016 | |
| GSE97050 | SEC62 | 7095 | A_23_P357860 | -0.1013 | 0.5900 | |
| SRP007169 | SEC62 | 7095 | RNAseq | 1.3535 | 0.0019 | |
| SRP008496 | SEC62 | 7095 | RNAseq | 2.1871 | 0.0000 | |
| SRP064894 | SEC62 | 7095 | RNAseq | 0.4712 | 0.0471 | |
| SRP133303 | SEC62 | 7095 | RNAseq | 0.6693 | 0.0000 | |
| SRP159526 | SEC62 | 7095 | RNAseq | 0.7714 | 0.0064 | |
| SRP193095 | SEC62 | 7095 | RNAseq | 0.3926 | 0.0141 | |
| SRP219564 | SEC62 | 7095 | RNAseq | 0.1518 | 0.6991 | |
| TCGA | SEC62 | 7095 | RNAseq | -0.1442 | 0.0026 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SEC62 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC62:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC62 | 7095 | 22 | 0 | 8 | |
| GSE20123 | SEC62 | 7095 | 22 | 0 | 8 | |
| GSE43470 | SEC62 | 7095 | 24 | 0 | 19 | |
| GSE46452 | SEC62 | 7095 | 19 | 1 | 39 | |
| GSE47630 | SEC62 | 7095 | 27 | 2 | 11 | |
| GSE54993 | SEC62 | 7095 | 1 | 14 | 55 | |
| GSE54994 | SEC62 | 7095 | 41 | 0 | 12 | |
| GSE60625 | SEC62 | 7095 | 0 | 6 | 5 | |
| GSE74703 | SEC62 | 7095 | 20 | 0 | 16 | |
| GSE74704 | SEC62 | 7095 | 14 | 0 | 6 | |
| TCGA | SEC62 | 7095 | 80 | 0 | 16 |
Total number of gains: 270; Total number of losses: 23; Total Number of normals: 195.
Somatic mutations of SEC62:
Generating mutation plots.
Highly correlated genes for SEC62:
Showing top 20/309 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC62 | HOXC9 | 0.815487 | 3 | 0 | 3 |
| SEC62 | GYPE | 0.782136 | 3 | 0 | 3 |
| SEC62 | MYO10 | 0.757814 | 4 | 0 | 4 |
| SEC62 | DOHH | 0.744409 | 3 | 0 | 3 |
| SEC62 | CHP2 | 0.729786 | 4 | 0 | 4 |
| SEC62 | LINC00674 | 0.7118 | 4 | 0 | 3 |
| SEC62 | SPINK1 | 0.700776 | 3 | 0 | 3 |
| SEC62 | NTNG2 | 0.700752 | 3 | 0 | 3 |
| SEC62 | CLSTN3 | 0.699627 | 3 | 0 | 3 |
| SEC62 | RTN4RL1 | 0.694352 | 3 | 0 | 3 |
| SEC62 | LRFN1 | 0.692059 | 3 | 0 | 3 |
| SEC62 | FAM131A | 0.690016 | 8 | 0 | 7 |
| SEC62 | COL24A1 | 0.688535 | 4 | 0 | 4 |
| SEC62 | TRAIP | 0.686767 | 3 | 0 | 3 |
| SEC62 | FBRSL1 | 0.685577 | 5 | 0 | 3 |
| SEC62 | CMSS1 | 0.677781 | 4 | 0 | 3 |
| SEC62 | TNNC2 | 0.676312 | 3 | 0 | 3 |
| SEC62 | TRIM11 | 0.674276 | 3 | 0 | 3 |
| SEC62 | PNMA6A | 0.673479 | 4 | 0 | 3 |
| SEC62 | SHARPIN | 0.669073 | 4 | 0 | 3 |
For details and further investigation, click here
