| Full name: docking protein 1 | Alias Symbol: p62dok | ||
| Type: protein-coding gene | Cytoband: 2p13.1 | ||
| Entrez ID: 1796 | HGNC ID: HGNC:2990 | Ensembl Gene: ENSG00000115325 | OMIM ID: 602919 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
DOK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05162 | Measles |
Expression of DOK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOK1 | 1796 | 216835_s_at | 0.0578 | 0.8700 | |
| GSE20347 | DOK1 | 1796 | 216835_s_at | 0.1479 | 0.1773 | |
| GSE23400 | DOK1 | 1796 | 211121_s_at | -0.1530 | 0.0001 | |
| GSE26886 | DOK1 | 1796 | 216835_s_at | 0.3647 | 0.0086 | |
| GSE29001 | DOK1 | 1796 | 211121_s_at | -0.2795 | 0.0200 | |
| GSE38129 | DOK1 | 1796 | 216835_s_at | -0.0105 | 0.9251 | |
| GSE45670 | DOK1 | 1796 | 216835_s_at | -0.0211 | 0.8682 | |
| GSE53622 | DOK1 | 1796 | 151676 | 0.1767 | 0.1618 | |
| GSE53624 | DOK1 | 1796 | 151676 | 0.5819 | 0.0000 | |
| GSE63941 | DOK1 | 1796 | 216835_s_at | -0.9682 | 0.0047 | |
| GSE77861 | DOK1 | 1796 | 216835_s_at | -0.0776 | 0.6690 | |
| GSE97050 | DOK1 | 1796 | A_23_P5601 | 0.3059 | 0.2460 | |
| SRP007169 | DOK1 | 1796 | RNAseq | 1.1917 | 0.0938 | |
| SRP008496 | DOK1 | 1796 | RNAseq | 1.0940 | 0.0162 | |
| SRP064894 | DOK1 | 1796 | RNAseq | 0.7264 | 0.0496 | |
| SRP133303 | DOK1 | 1796 | RNAseq | 0.3353 | 0.1188 | |
| SRP159526 | DOK1 | 1796 | RNAseq | 0.9981 | 0.0054 | |
| SRP193095 | DOK1 | 1796 | RNAseq | 0.2479 | 0.3400 | |
| SRP219564 | DOK1 | 1796 | RNAseq | 0.8343 | 0.1159 | |
| TCGA | DOK1 | 1796 | RNAseq | -0.3539 | 0.0021 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DOK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOK1 | 1796 | 9 | 2 | 19 | |
| GSE20123 | DOK1 | 1796 | 10 | 2 | 18 | |
| GSE43470 | DOK1 | 1796 | 4 | 0 | 39 | |
| GSE46452 | DOK1 | 1796 | 2 | 3 | 54 | |
| GSE47630 | DOK1 | 1796 | 7 | 0 | 33 | |
| GSE54993 | DOK1 | 1796 | 0 | 6 | 64 | |
| GSE54994 | DOK1 | 1796 | 10 | 0 | 43 | |
| GSE60625 | DOK1 | 1796 | 0 | 3 | 8 | |
| GSE74703 | DOK1 | 1796 | 4 | 0 | 32 | |
| GSE74704 | DOK1 | 1796 | 8 | 0 | 12 | |
| TCGA | DOK1 | 1796 | 37 | 2 | 57 |
Total number of gains: 91; Total number of losses: 18; Total Number of normals: 379.
Somatic mutations of DOK1:
Generating mutation plots.
Highly correlated genes for DOK1:
Showing top 20/679 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOK1 | GPRIN3 | 0.798449 | 3 | 0 | 3 |
| DOK1 | LACTB | 0.78469 | 3 | 0 | 3 |
| DOK1 | NOSIP | 0.781425 | 3 | 0 | 3 |
| DOK1 | DOCK10 | 0.764954 | 3 | 0 | 3 |
| DOK1 | CERKL | 0.755156 | 3 | 0 | 3 |
| DOK1 | RAB23 | 0.752626 | 3 | 0 | 3 |
| DOK1 | CDAN1 | 0.749021 | 3 | 0 | 3 |
| DOK1 | MYCN | 0.747214 | 3 | 0 | 3 |
| DOK1 | C19orf18 | 0.740771 | 3 | 0 | 3 |
| DOK1 | ZNF276 | 0.740103 | 3 | 0 | 3 |
| DOK1 | C11orf96 | 0.735375 | 3 | 0 | 3 |
| DOK1 | SERPINB9 | 0.729905 | 3 | 0 | 3 |
| DOK1 | GLIS2 | 0.726575 | 4 | 0 | 4 |
| DOK1 | FCGR3A | 0.725457 | 3 | 0 | 3 |
| DOK1 | NEK6 | 0.723175 | 5 | 0 | 5 |
| DOK1 | C19orf38 | 0.722181 | 3 | 0 | 3 |
| DOK1 | HLA-E | 0.719303 | 3 | 0 | 3 |
| DOK1 | HVCN1 | 0.71809 | 4 | 0 | 4 |
| DOK1 | CSF1R | 0.717995 | 5 | 0 | 4 |
| DOK1 | ABHD16B | 0.713743 | 4 | 0 | 3 |
For details and further investigation, click here
